公开(公告)号：US20190321440A1

公开(公告)日：2019-10-24

申请号：US16389292

申请日：2019-04-19

申请人： Hoffmann-La Roche Inc.

发明人： Konrad BLEICHER ,  Daniella CHEANG ,  Patrick DI GIORGIO ,  Taishan HU ,  Christian JENNY ,  Patrizio MATTEI ,  Petra SCHMITZ ,  Theodor STOLL

IPC分类号： A61K38/12 ,  A61P31/04

摘要： The present invention provides compounds of formula (I) wherein X1, X2, R1 to R6 and A are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by bacteria.

公开(公告)号：US20200040032A1

公开(公告)日：2020-02-06

申请号：US16596243

申请日：2019-10-08

申请人： Hoffmann-La Roche Inc.

发明人： Konrad BLEICHER ,  Jérôme HERT ,  Carsten KROLL ,  Fabian DEY

IPC分类号： C07K5/09 ,  A61P31/04

摘要： The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R8′, R9, R9′, X1, X2, X3, X4, X5, X6, X7, X8, X9 and X10 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by Acinetobacter baurnannii.

公开(公告)号：US20160310575A1

公开(公告)日：2016-10-27

申请号：US15102340

申请日：2014-12-19

申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION ,  HOFFMANN-LA ROCHE INC.

发明人： Sara BELLI ,  Konrad BLEICHER ,  Richard D. DIMARCHI ,  Eike HOFFMANN ,  Eric A. KITAS ,  Anish A. KONKAR

IPC分类号： A61K38/26 ,  A61K45/06 ,  A61K47/48 ,  C07K14/605

CPC分类号： A61K38/26 ,  A61K38/00 ,  A61K45/06 ,  A61K47/543 ,  C07K14/605 ,  C07K2319/30

摘要： Herein is reported a fusion polypeptide comprising i) one, two, three or four incretin receptor ligand polypeptides, and ii) one human immunoglobulin Fc-region, wherein at least one of the incretin receptor ligand polypeptides comprises an amino acid that is covalently conjugated to a lipid, and wherein each of the one, two, three or four incretin receptor ligand polypeptides is covalently conjugated by a peptide bond to a terminus of the human immunoglobulin Fc-region, whereby to each terminus of the human immunoglobulin Fc-region only a single incretin receptor ligand polypeptide is conjugated.

摘要翻译： 本文报道了融合多肽，其包含i）一个，两个，三个或四个肠降索内酯受体配体多肽，和ii）一个人免疫球蛋白Fc区，其中至少一个肠降血糖素受体配体多肽包含共价共轭 脂质，并且其中所述一个，两个，三个或四个肠降血糖素受体配体多肽中的每一个通过肽键共价结合到人免疫球蛋白Fc区的末端，由此到达人免疫球蛋白Fc区的每个末端只有 将单一肠降血糖素受体配体多肽缀合。