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    PROCESS FOR PREPARING 2-HYDROXYACETALS AND THE CORRESPONDING 2-HYDROXYALKANALS
    21.
    发明申请
    PROCESS FOR PREPARING 2-HYDROXYACETALS AND THE CORRESPONDING 2-HYDROXYALKANALS 失效
    制备2-羟基乙酸和相应的2-羟基烷基胺的方法

    公开(公告)号：US20100280276A1

    公开(公告)日：2010-11-04

    申请号：US12665375

    申请日：2008-06-11

    申请人： Thomas-Norbert Mueller ,  Michael Dockner

    发明人： Thomas-Norbert Mueller ,  Michael Dockner

    IPC分类号： C07C45/42 ,  C07C41/50

    CPC分类号： C07C41/50 ,  C07C43/315 ,  C07C45/515 ,  C07C67/287 ,  C07C47/19 ,  C07C69/003 ,  C07C69/63

    摘要： What is described is a process for preparing 2-hydroxyacetals of the general formula in which R1 is hydrogen, a branched or unbranched C1-C12-alkyl radical, an electron-deficient, halogen-, NO2—, CN—, CF3—, acyl group- or branched or unbranched alkyl group-substituted or unsubstituted C5-C6-aryl or heteroaryl, and R2 is a branched or unbranched C1-C5-alkyl radical, or both R2 radicals are bonded directly to one another or to one another via a C1-C4 unit, by reacting an enol compound of the general formula (II) in which R3 is the same and R1 is as defined for formula (Ia), with bromine to give the corresponding dibromo adduct and then reacting this dibromo adduct with an alkoxide of the general formula (III) M-O—R2 (III) in which R2 is as defined for formula (Ia) and O is oxygen and M is lithium, sodium or potassium. What is likewise described is the preparation of the corresponding 2-hydroxyalkanals from the 2-hydroxyacetals thus obtained by acidic hydrolysis.

    摘要翻译： 描述的是制备通式的2-羟基缩醛的方法，其中R 1是氢，支链或非支链C 1 -C 12 - 烷基，缺电子，卤素，NO 2 - ，CN-，CF 3 - ，酰基 基团或支链或非支链烷基 - 取代或未取代的C 5 -C 6 - 芳基或杂芳基，并且R 2是支链或非支链C 1 -C 5 - 烷基，或两个R 2基团彼此直接键合或通过 通过使其中R 3相同的通式（II）的烯醇化合物与式（Ia）所定义的R 1与溴反应，得到相应的二溴加合物，然后使该二溴加合物与 （III）的醇盐，其中R 2如式（Ia）所定义，O是氧，M是锂，钠或钾。 同样描述的是通过酸性水解由如此获得的2-羟基缩醛制备相应的2-羟基卡那烯。