FLUORINATED SURFACTANTS
    6.
    发明申请
    FLUORINATED SURFACTANTS 审中-公开
    氟化表面活性剂

    公开(公告)号:US20130284048A1

    公开(公告)日:2013-10-31

    申请号:US13924976

    申请日:2013-06-24

    Abstract: A composition of formula I [Rf(CH2)m(O)n]x-A wherein Rf is a straight or branched perfluoroalkyl group having from about 2 to about 20 carbon atoms, or a mixture thereof, m is a positive integer equal to or greater than 3, n is 0 or 1, x is 1 to about 3, and A is —P(O)(OR1)y(OM+)3-y-x, —C(O)CH(SO3−M+)CH2C(O)−, —(CH2CH2O)d(CH2CHR2O)eR3, or −SO2B, M+ is an alkali metal ion, NH4+, or NH2(CH2CH2OH)2, B is N(R)2 or N(CH2CH3)(CH2CH2OH), R1 is C1 to C3 alkyl, and R2 is C1 to C4 alkyl, R3 is H or CH3, y is 0 to about 1, d is 0 to about 16, e is 0 to about 16, provided that (d+e) is from about 3 to about 16 is disclosed.

    Abstract translation: 式I [Rf(CH 2)m(O)n] x A的组合物,其中Rf是具有约2至约20个碳原子的直链或支链全氟烷基,或其混合物,m是等于或大于 (O)(OR 1)y(OM +)3-yx,-C(O)CH(SO 3 -M +)CH 2 C(O) - , - (CH2CH2O)d(CH2CHR2O)eR3或-SO2B,M +是碱金属离子,NH4 +或NH2(CH2CH2OH)2,B是N(R)2或N(CH2CH3)(CH2CH2OH) C1至C3烷基,R2为C1至C4烷基,R3为H或CH3,y为0至约1,d为0至约16,e为0至约16,条件是(d + e)为约 3〜16。

    METHOD FOR PRODUCING TETRAFLUORO COMPOUND
    8.
    发明申请
    METHOD FOR PRODUCING TETRAFLUORO COMPOUND 有权
    生产四氯氟氰化合物的方法

    公开(公告)号:US20110178323A1

    公开(公告)日:2011-07-21

    申请号:US13121267

    申请日:2009-10-02

    Abstract: Provided is a method for producing a tetrafluoro nitrogen-containing heterocyclic compound such as tetrafluoropyrrolidine in good yield and at low cost. The method comprises the steps of: (A) reacting a compound represented by the formula (I) with fluorine gas to produce a tetrafluoro compound represented by the formula (II), (B) converting the tetrafluoro derivative represented by the formula (II) to a compound represented by the formula (III), and (C) reacting the compound represented by the formula (III) with an amine compound represented by the formula NH2R9 to produce a tetrafluoro nitrogen-containing heterocyclic compound represented by the formula (IV) or salt thereof.

    Abstract translation: 提供了以高收率和低成本生产四氟代吡咯烷等四氟含氮杂环化合物的方法。 该方法包括以下步骤:(A)使由式(I)表示的化合物与氟气反应,生成由式(II)表示的四氟化合物,(B)将由式(II)表示的四氟衍生物 与式(III)表示的化合物反应,和(C)使由式(III)表示的化合物与由式NH 2 R 9表示的胺化合物反应,得到由式(IV)表示的四氟含氮杂环化合物, 或其盐。

    NOVEL SIRTUIN ACTIVATING COMPOUNDS AND PROCESSES FOR MAKING THE SAME
    9.
    发明申请
    NOVEL SIRTUIN ACTIVATING COMPOUNDS AND PROCESSES FOR MAKING THE SAME 有权
    新型SIRTUIN活化化合物及其制备方法

    公开(公告)号:US20100185006A1

    公开(公告)日:2010-07-22

    申请号:US12503239

    申请日:2009-07-15

    Abstract: The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from 2 to 6 carbon atoms and cycloalkyl of from 3 to 8 carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbene-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.

    Abstract translation: 本发明包括用于制备下列给出的式的白藜芦醇,白藜芦醇酯和取代和未取代的二苯乙烯的方法; 其中每个Y是-O或卤素,每个Z是-O或卤素,每个n和每个m独立地是0,1,2,3,4或5的值,每个A和每个B独立地选自Pn, R或不存在,每个V和每个W独立地选自Pn,2至6个碳原子的直链或支链烷基和3至8个碳原子的环烷基,烷氧基,苯基,苄基或卤素,R独立地选自 包含至少一个碳原子的烷基,芳基和芳烷基,Pn是上述的醇保护基和非对映异构体。 所述化合物由多步法制备,包括在碱存在下与苄氧基卤化物和苯乙烯偶联配偶体的N-杂环卡宾型配体偶联。 这些化合物在食品,化妆品和制药工业中显示出增加的稳定性。

    Sirtuin activating compounds and methods for making the same
    10.
    发明授权
    Sirtuin activating compounds and methods for making the same 有权
    Sirtuin活化化合物及其制备方法

    公开(公告)号:US07714161B2

    公开(公告)日:2010-05-11

    申请号:US10597335

    申请日:2005-01-19

    Abstract: The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from (2) to (6) carbon atoms and cycloalkyl of from (3) to (8) carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbene-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.

    Abstract translation: 本发明包括用于制备下列给出的式的白藜芦醇,白藜芦醇酯和取代和未取代的二苯乙烯的方法; 其中每个Y是-O或卤素,每个Z是-O或卤素,每个n和每个m独立地是0,1,2,3,4或5的值,每个A和每个B独立地选自Pn, R或不存在,每个V和每个W独立地选自(2)至(6)个碳原子的直链或支链烷基,(3)至(8)碳原子的烷基,烷氧基,苯基,苄基或 卤素,R独立地选自烷基与至少一个碳原子的基团,芳基和芳烷基,Pn是醇保护基和前述的非对映异构体。 所述化合物由多步法制备,包括在碱存在下与苄氧基卤化物和苯乙烯偶联配偶体的N-杂环卡宾型配体偶联。 这些化合物在食品,化妆品和制药工业中显示出增加的稳定性。

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