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公开(公告)号:US20080096913A1
公开(公告)日:2008-04-24
申请号:US12001026
申请日:2007-12-07
申请人: James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
发明人: James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
IPC分类号: A61K31/44 , A61K31/40 , A61K31/47 , A61P3/04 , A61K31/405
CPC分类号: C04B35/632 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04
摘要: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译: 描述了对PPARs有活性的化合物,包括泛活性化合物。 还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。
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公开(公告)号:US20070149603A1
公开(公告)日:2007-06-28
申请号:US11679777
申请日:2007-02-27
申请人: James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
发明人: James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
IPC分类号: C07D209/18 , A61K31/405
CPC分类号: C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译: 描述了对PPARs有活性的化合物,包括泛活性化合物。 还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。
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公开(公告)号:US20050288354A1
公开(公告)日:2005-12-29
申请号:US10937791
申请日:2004-09-08
申请人: James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
发明人: James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
IPC分类号: C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04 , A61K31/404
CPC分类号: C04B35/632 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04
摘要: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
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公开(公告)号:US20050038246A1
公开(公告)日:2005-02-17
申请号:US10893134
申请日:2004-07-16
申请人: James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
发明人: James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
IPC分类号: C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D471/02 , C07D487/02
CPC分类号: C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译: 描述了对PPARs有活性的化合物,包括泛活性化合物。 还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。
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公开(公告)号:US09624213B2
公开(公告)日:2017-04-18
申请号:US13820734
申请日:2012-02-01
申请人: Prabha Ibrahim , Chao Zhang , Wayne Spevak , Jiazhong Zhang , Guoxian Wu , Jack Lin , Hanna Cho , Marika Nespi , Songyuan Shi , Todd Ewing , Ying Zhang
发明人: Prabha Ibrahim , Chao Zhang , Wayne Spevak , Jiazhong Zhang , Guoxian Wu , Jack Lin , Hanna Cho , Marika Nespi , Songyuan Shi , Todd Ewing , Ying Zhang
IPC分类号: C07D471/04 , A61K31/506 , A61K31/437 , A61K31/5377
CPC分类号: A61K31/506 , A61K31/437 , A61K31/5377 , C07D471/04
摘要: Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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公开(公告)号:US20080045581A1
公开(公告)日:2008-02-21
申请号:US11679792
申请日:2007-02-27
申请人: James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
发明人: James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
IPC分类号: A61K31/404 , A61P3/00 , A61P35/00 , A61P9/00 , C07D209/18 , C07D409/12
CPC分类号: C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译: 描述了对PPARs有活性的化合物,包括泛活性化合物。 还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。
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公开(公告)号:US20070155818A1
公开(公告)日:2007-07-05
申请号:US11679738
申请日:2007-02-27
申请人: Dean Artis , Prabha Ibrahim , Jack Lin , Chao Zhang
发明人: Dean Artis , Prabha Ibrahim , Jack Lin , Chao Zhang
IPC分类号: A61K31/404 , C07D209/18
CPC分类号: C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
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公开(公告)号:US08622400B2
公开(公告)日:2014-01-07
申请号:US12764952
申请日:2010-04-22
申请人: Jack Lin
发明人: Jack Lin
IPC分类号: B23B31/107
CPC分类号: B23B31/1071 , B23B31/1074 , B23D51/10 , B25B15/001 , B25B23/0035
摘要: A tool includes a chuck connected to a handle. The chuck includes a mandrel including a non-circular cavity defined therein, a slit in communication with the non-circular cavity, a first bore in communication with the non-circular cavity, and a second bore in communication with the slit. A bit with a non-circular profile can be inserted in the non-circular cavity. A flat bit can be inserted in the slit. A ball is located in the first bore. A pin is located in the second bore. A movable sleeve is located around and movable along the mandrel and formed with a thread. A rotary sleeve is rotationally located around the mandrel and formed with a thread engaged with the thread of the movable sleeve. By rotating the rotary sleeve, the movable sleeve pushes the ball into the non-circular cavity and the pin into the slit.
摘要翻译: 工具包括连接到手柄的卡盘。 卡盘包括心轴,其包括限定在其中的非圆形腔,与非圆形腔连通的狭缝,与非圆形腔连通的第一孔以及与狭缝连通的第二孔。 具有非圆形轮廓的位可以插入非圆形腔中。 平缝可插入狭缝中。 一个球位于第一个孔中。 销位于第二孔中。 可移动套筒位于心轴周围并可沿心轴移动并形成一根线。 旋转套筒旋转地位于心轴周围,并形成有与可动套筒的螺纹接合的螺纹。 通过旋转旋转套筒,可移动套筒将球推入非圆形空腔并将销推入狭缝中。
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公开(公告)号:US20130186244A1
公开(公告)日:2013-07-25
申请号:US13353543
申请日:2012-01-19
申请人: Jack Lin
发明人: Jack Lin
IPC分类号: B23B31/107 , B25G1/00
CPC分类号: B25G1/005 , Y10T279/17461
摘要: Disclosed is a chuck including a body, at least one ball and a helical spring. The body includes an axial space defined therein and at least one radial bore with a small open end near the axial space and a large open end in an external side thereof. The ball includes a first section movably placed in the radial bore, a second section movable into the axial space, and a third section movably placed outside the radial bore. The helical spring is placed around the body and in contact with the third section of the ball for biasing the second section of the ball into a recess defined in a bit inserted in the axial space.
摘要翻译: 公开了一种卡盘,其包括主体,至少一个球和螺旋弹簧。 主体包括限定在其中的轴向空间和至少一个在轴向空间附近具有小开口端的径向孔和在其外侧的大开口端。 球包括可移动地放置在径向孔中的第一部分,可移动到轴向空间中的第二部分和可移动地放置在径向孔外侧的第三部分。 螺旋弹簧围绕主体放置并与球的第三部分接触,用于将球的第二部分偏压到限定在插入轴向空间的钻头中的凹部中。
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公开(公告)号:US07661526B2
公开(公告)日:2010-02-16
申请号:US12102037
申请日:2008-04-14
申请人: Jack Lin
发明人: Jack Lin
IPC分类号: B65D85/28
CPC分类号: B25H3/003
摘要: A toolbox includes a shell, a holder and a cover. The shell includes two grooves defined therein and two inclined faces formed thereon near the grooves. The holder is disposed in the shell and formed with a plurality of holes for receiving bits. The cover includes two lugs extended from a side thereof and two blocks each formed on a related one of the lugs and formed with an inclined face. The blocks are movably disposed in the grooves so that the cover can be moved relative to the shell. When the cover is moved away from the shell, the cover can be pivoted relative to the shell so that the inclined faces of the blocks are located against the inclined faces of the shell, thus limiting the pivoting of the cover relative to the shell.
摘要翻译: 工具箱包括外壳,支架和盖子。 壳体包括限定在其中的两个凹槽和在凹槽周围形成的两个倾斜面。 保持器设置在壳体中并形成有用于接收钻头的多个孔。 该盖包括从其一侧延伸的两个凸耳和两个块,每个凸块形成在相关的一个凸耳上并形成有倾斜面。 这些块可移动地设置在槽中,使得盖可以相对于壳移动。 当盖子远离壳体时,盖子可以相对于壳体枢转,使得块体的倾斜面抵靠壳体的倾斜面定位,从而限制盖子相对于壳体的枢转。
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