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22 条记录 (耗时 0.021 秒)

    Method for regulating IL-10 with IL-9, and applications thereof
    21.
    发明授权
    Method for regulating IL-10 with IL-9, and applications thereof 失效

    公开(公告)号：US06558660B2

    公开(公告)日：2003-05-06

    申请号：US09898627

    申请日：2001-07-02

    申请人： Ursula Grohman ,  Jacques Van Snick

    发明人： Ursula Grohman ,  Jacques Van Snick

    IPC分类号： A61K3820

    CPC分类号： A61K38/206 ,  A61K31/52 ,  Y02A50/473 ,  Y10S514/885 ,  A61K2300/00

    摘要： The invention involves the recognition of IL-9 as a molecule involved in induction of IL-10. Administration of IL-9 leads to protection against conditions where IL-10 production is warranted, such as infections by Gram negative bacteria. Examples of such conditions are septic shock and endotoxemia. Also a part of the invention are methods of treatment where IL-9 and a phosphodiesterase inhibitor are administered to a subject. Compositions, such as kits which include these two components are a part of the invention, as is treatment of conditions involving excess IL-10 production by administering an IL-9 inhibitor.

    Process for preparing mammalian T cell growth factor P40
    22.
    发明授权
    Process for preparing mammalian T cell growth factor P40 失效
    制备哺乳动物T细胞生长因子P40的方法

    公开(公告)号：US5750377A

    公开(公告)日：1998-05-12

    申请号：US447805

    申请日：1995-05-23

    申请人： Jacques Van Snick ,  Catherine Uyttenhove ,  Richard J. Simpson

    发明人： Jacques Van Snick ,  Catherine Uyttenhove ,  Richard J. Simpson

    IPC分类号： A61K38/00 ,  A61P43/00 ,  C07K14/54 ,  C07K16/24 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12R1/91 ,  C07K1/18 ,  C07K1/20

    CPC分类号： C07K16/244 ,  C07K14/5425 ,  A61K38/00

    摘要： The present invention relates generally to a T cell growth factor. More particularly, the present invention relates to a T cell growth factor which comprises a glycoprotein which supports interleukin 2- and interleukin 4-independent growth of helper T cells especially from murine and human sources and further which is capable of augmenting proliferation of IL3- or IL4-responsive cells. Even more particularly, the present invention relates to the helper T cell growth factor P40, pharmaceutical compositions thereof, antibodies thereto and recombinant DNA clones thereof. The present invention also contemplates a method for inducing the proliferation of helper T cells as well as IL3- and Il4-responsive cells. The helper T cells growth factor contemplated herein is useful in the stimulation of specific cells in the immune system, either alone or in combination with IL3 or IL4.

    摘要翻译： 本发明一般涉及T细胞生长因子。 更具体地，本发明涉及一种T细胞生长因子，其包含支持辅助性T细胞的白细胞介素2-和白细胞介素4非依赖性生长的糖蛋白，特别是来自鼠源和人来源，并且还能够增强IL3-或 IL4反应细胞。 更具体地，本发明涉及辅助性T细胞生长因子P40，其药物组合物，其抗体及其重组DNA克隆。 本发明还考虑了一种诱导辅助性T细胞以及IL3和II4反应性细胞增殖的方法。 本文考虑的辅助T细胞生长因子可用于单独或与IL3或IL4组合在免疫系统中刺激特异性细胞。