Methods for treating multiple sclerosis
    23.
    发明申请
    Methods for treating multiple sclerosis 审中-公开
    治疗多发性硬化症的方法

    公开(公告)号:US20070167360A1

    公开(公告)日:2007-07-19

    申请号:US10577506

    申请日:2004-10-28

    申请人: Shi Yan David Stern

    发明人: Shi Yan David Stern

    IPC分类号: A61K38/17

    CPC分类号: A61K31/00 A61K38/1774

    摘要: This invention provides a method for treating a subject afflicted with multiple sclerosis comprising administering to the subject a therapeutically effective amount of soluble receptor for advanced glycation endproducts (sRAGE). This invention further provides a method for inhibiting CD4+ T-cell migration comprising contacting the CD4+ T-cell with soluble receptor for advanced glycation endproducts (sRAGE). This invention further provides a method for inhibiting chemokine receptor activation in a subject comprising administering to the subject a therapeutically effective amount of soluble receptor for advanced glycation endproducts (sRAGE).

    摘要翻译: 本发明提供了治疗患有多发性硬化症的受试者的方法,其包括向受试者施用治疗有效量的晚期糖基化终产物(sRAGE)的可溶性受体。 本发明进一步提供了一种抑制CD4 + T细胞迁移的方法,包括使CD4 + T细胞与晚期糖基化终产物(sRAGE)的可溶性受体接触。 本发明进一步提供了一种用于抑制受试者中趋化因子受体活化的方法,包括向受试者施用治疗有效量的晚期糖基化终产物(sRAGE)的可溶性受体。