摘要:
The present invention provides pharmaceutical formulations comprising a solid ionic complex of a polypeptide having an isoelectric point lower than physiological pH and an anionic carrier molecule. The formulations of the invention are suitable as depot formulations for the sustained release of therapeutic polypeptides.
摘要:
The present invention provides a series of aspherical contact lenses, each lens having a first central optical zone on its anterior surface and a second central optical zone on its posterior surface. Both central optical zones are aspherical surfaces. The first central optical zone is designed to have a surface which provides a target optical power and an optical power profile selected from the group consisting of (1) a substantially constant optical power profile, (2) a power profile mimicking the optical power profile of a spherical lens with an identical targeted optical power, and (3) a power profile in which lens spherical aberration at 6 mm diameter is from about 0.65 diopter to about 1.8 diopters more negative than spherical aberration at 4 mm diameter.
摘要:
The present invention provides a contact lens having an orientation feature that does not provide an prism optical distortion and can maintain a predetermined orientation of the lens on an eye. A contact lens of the invention comprises an anterior surface and an opposite posterior surface. The anterior surface includes a vertical meridian, a horizontal meridian, a central optical zone, a blending zone extending outwardly from the central optical zone, a peripheral zone surrounding the blending zone, and an edge zone circumscribing and tangent to the peripheral zone. The presence of the blending zone ensures that the peripheral zone, the blending zone and the central optical zone are tangent to each other. The peripheral zone has a surface that, in combination with the posterior surface, provides in the peripheral zone a lens thickness which is characterized (1) by having a lens thickness which increases progressively from the top of the lens downwardly along each of the vertical meridian and lines parallel to the vertical meridian until reaching a maximum value at a position between the optical zone and the edge zone and then decreases to the edge of the edge zone; or (2) by having a mirror symmetry with respect to a plane cutting through the vertical meridian, by having a substantially constant thickness in a region around the horizonal meridian and by having a thickness which decreases progressively from the horizontal meridian to the top or bottom of the contact lens along each of the vertical meridian and lines parallel to the vertical meridian.
摘要:
Methods, systems, and computer-readable media for ascertaining neighborhood information in a dynamically changing environment, such as an electronic ink environment may include: (a) receiving data representing plural electronic ink strokes; (b) defining a first vertex associated with a first ink stroke; and (c) determining neighboring vertices to the first vertex, wherein the neighboring vertices are associated with ink stroke(s) other than the first ink stroke. Additional systems, methods, and computer-readable media may include: (a) receiving data representing plural electronic ink strokes; (b) defining plural vertices associated with the ink strokes; (c) receiving input indicating a selection of an ink component; and (d) determining at least one neighboring component by determining which ink component(s) located outside of the selection include one or more ink strokes having vertices that neighbor vertices included in the selection.
摘要:
This invention is related to contact lenses. In particular, the present invention is related to a toric contact lens design with thickness zones in the carrier portion of the lens for increased rotational stability.
摘要:
This invention is related to contact lenses. In particular, the present invention is related to a toric contact lens design with thickness zones in the carrier portion of the lens for increased rotational stability.
摘要:
A method for grouping writing regions of digital ink receives processed digital ink that comprises writing regions. A relationship can be generated between a plurality of the writing regions. A feature set can be determined that is associated with the plurality of the writing regions. The plurality of the writing regions can be grouped based on the feature set.
摘要:
The present invention provides pharmaceutical formulations comprising a solid ionic complex of a polypeptide having an isoelectric point lower than physiological pH and an anionic carrier molecule. The formulations of the invention are suitable as depot formulations for the sustained release of therapeutic polypeptides.
摘要:
The present invention provides pharmaceutical formulations comprising a solid ionic complex of a polypeptide having an isoelectric point lower than physiological pH and an anionic carrier molecule. The formulations of the invention are suitable as depot formulations for the sustained release of therapeutic polypeptides.
摘要:
A contact lens has top, a bottom, a rotational axis, an inner surface and an opposite outer surface having a plurality of zones. The plurality of zones include an optical zone, a ridge zone and a transition zone. The optical zone has a lower edge and includes a distance vision zone and a near vision zone. The distance vision zone has a first radius of curvature that provides distance vision correction. The distance vision zone also has a first area that is sufficient to overlay a substantial portion of a pupil of a user and is disposed in a first position within the optical zone so that the user's pupil is substantially subtended by the distance vision zone when the user is gazing at a substantially horizontal point. The near vision zone is substantially concentric with the rotational axis and extends radially outward from the distance vision zone. The near vision zone has a second radius of curvature that provides near vision correction and has a second area that is sufficient to overlay a substantial portion of a pupil of a user. The near vision zone is disposed in a second position within the optical zone so that the user's pupil is substantially subtended by the near vision zone when the user is gazing at a near vision point below the substantially horizontal point. The ridge zone, has an upper edge and a lower edge and is disposed below the optical zone. The ridge zone includes a latitudinal ridge portion that extends outwardly from the outer surface to enable engagement with a lower eyelid of a user and thereby provide vertical translation support for the contact lens when being worn by the user. The transition zone extends from the lower edge of the optical zone to the upper edge of the ridge zone and provides a smooth transition from the ridge zone to the optical zone.