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    Pharmaceutical formulations for sustained drug delivery
    4.
    发明申请
    Pharmaceutical formulations for sustained drug delivery 审中-公开

    公开(公告)号：US20070185032A1

    公开(公告)日：2007-08-09

    申请号：US11265520

    申请日：2005-11-02

    申请人： Malcolm Gefter ,  Nicholas Barker ,  Gary Musso ,  Christopher Molineaux

    发明人： Malcolm Gefter ,  Nicholas Barker ,  Gary Musso ,  Christopher Molineaux

    IPC分类号： A61K38/09 ,  A61K38/08 ,  A61K9/14

    CPC分类号： A61K38/09 ,  A61K47/61

    摘要： Sustained delivery formulations comprising a water-insoluble complex of a peptidic compound (e.g., a peptide, polypeptide, protein, peptidomimetic or the like) and a carrier macromolecule are disclosed. The formulations of the invention allow for loading of high concentrations of peptidic compound in a small volume and for delivery of a pharmaceutically active peptidic compound for prolonged periods, e.g., one month, after administration of the complex. The complexes of the invention can be milled or crushed to a fine powder. In powdered form, the complexes form stable aqueous suspensions and dispersions, suitable for injection. In a preferred embodiment, the peptidic compound of the complex is an LHRH analogue, preferably an LHRH antagonist, and the carrier macromolecule is an anionic polymer, preferably carboxymethylcellulose. Methods of making the complexes of the invention, and methods of using LHRH-analogue-containing complexes to treat conditions treatable with an LHRH analogue, are also disclosed.

    Pharmaceutical formulations for sustained drug delivery
    5.
    发明授权
    Pharmaceutical formulations for sustained drug delivery 失效
    用于持续给药的药物制剂

    公开(公告)号：US5968895A

    公开(公告)日：1999-10-19

    申请号：US762747

    申请日：1996-12-11

    申请人： Malcolm L. Gefter ,  Nicholas Barker ,  Gary Musso ,  Christopher J. Molineaux

    发明人： Malcolm L. Gefter ,  Nicholas Barker ,  Gary Musso ,  Christopher J. Molineaux

    IPC分类号： A61K47/30 ,  A61K9/22 ,  A61K38/04 ,  A61K38/09 ,  A61K38/22 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/48 ,  A61P15/00 ,  A61P15/18 ,  A61P35/00 ,  A61R38/00

    CPC分类号： B82Y5/00 ,  A61K38/09 ,  A61K47/4823 ,  A61K47/48961 ,  Y10S514/80

    摘要： Sustained delivery formulations comprising a water-insoluble complex of a peptide and a carrier macromolecule are disclosed. The formulations of the invention allow for loading of high concentrations of peptide in a small volume and for delivery of a pharmaceutically active peptide for prolonged periods, e.g., one month, after administration of the complex. The complexes of the invention can be milled or crushed to a fine powder. In powdered form, the complexes form stable aqueous suspensions and dispersions, suitable for injection. In a preferred embodiment, the peptide of the complex is an LHRH analogue, preferably an LHRH antagonist, and the carrier macromolecule is an anionic polymer, preferably carboxymethylcellulose. Methods of making the complexes of the invention, and methods of using LHRH-analogue-containing complexes to treat conditions treatable with an LHRH analogue, are also disclosed.

    摘要翻译： 公开了包含肽和载体大分子的水不溶性络合物的持续递送制剂。 本发明的制剂允许在施用复合物之后以较小的体积装载高浓度的肽并延长药物活性肽的递送时间，例如一个月。 本发明的络合物可以研磨或粉碎成细粉末。 以粉末形式，络合物形成稳定的水性悬浮液和分散体，适于注射。 在优选的实施方案中，复合物的肽是LHRH类似物，优选LHRH拮抗剂，载体大分子是阴离子聚合物，优选羧甲基纤维素。 还公开了制备本发明复合物的方法，以及使用含LHRH类似物的复合物治疗可用LHRH类似物治疗的病症的方法。

    Pharmaceutical formulations for sustained drug delivery
    6.
    发明授权
    Pharmaceutical formulations for sustained drug delivery 失效
    用于持续给药的药物制剂

    公开(公告)号：US06699833B1

    公开(公告)日：2004-03-02

    申请号：US09349914

    申请日：1999-07-08

    申请人： Malcolm L. Gefter ,  Nicholas Barker ,  Gary Musso ,  Christopher J. Molineaux

    发明人： Malcolm L. Gefter ,  Nicholas Barker ,  Gary Musso ,  Christopher J. Molineaux

    IPC分类号： A61K3800

    CPC分类号： B82Y5/00 ,  A61K38/09 ,  A61K47/61 ,  A61K47/6949 ,  Y10S514/80

    摘要： Sustained delivery formulations comprising a water-insoluble complex of a peptide and a carrier macromolecule are disclosed. The formulations of the invention allow for loading of high concentrations of peptide in a small volume and for delivery of a pharmaceutically active peptide for prolonged periods, e.g., one month, after administration of the complex. The complexes of the invention can be milled or crushed to a fine powder. In powdered form, the complexes form stable aqueous suspensions and dispersions, suitable for injection. In a preferred embodiment, the peptide of the complex is an LHRH analogue, preferably an LHRH antagonist, and the carrier macromolecule is an anionic polymer, preferably carboxymethylcellulose. Methods of making the complexes of the invention, and methods of using LHRH-analogue-containing complexes to treat conditions treatable with an LHRH analogue, are also disclosed.

    摘要翻译： 公开了包含肽和载体大分子的水不溶性络合物的持续递送制剂。 本发明的制剂允许在施用复合物之后以较小的体积装载高浓度的肽并延长药物活性肽的递送时间，例如一个月。 本发明的络合物可以研磨或粉碎成细粉末。 以粉末形式，络合物形成稳定的水性悬浮液和分散体，适于注射。 在优选的实施方案中，复合物的肽是LHRH类似物，优选LHRH拮抗剂，载体大分子是阴离子聚合物，优选羧甲基纤维素。 还公开了制备本发明复合物的方法，以及使用含LHRH类似物的复合物治疗可用LHRH类似物治疗的病症的方法。

    Pharmaceutical formulations for sustained release
    7.
    发明申请
    Pharmaceutical formulations for sustained release 审中-公开

    公开(公告)号：US20060293217A1

    公开(公告)日：2006-12-28

    申请号：US11205296

    申请日：2005-08-15

    申请人： Nicholas Barker ,  Janet Wolfe

    发明人： Nicholas Barker ,  Janet Wolfe

    IPC分类号： A61K38/00 ,  A61K31/715

    CPC分类号： A61K31/715 ,  A61K47/61

    摘要： Sustained delivery pharmaceutical compositions comprising a solid ionic complex of a pharmaceutically active compound and an ionic macromolecule are provided by the present invention. The pharmaceutical compositions of the invention allow for loading of high concentrations of pharmaceutically active compounds and for delivery of a pharmaceutically active compound for prolonged periods of time, e.g., one month, after administration. Methods for preparing these pharmaceutical compositions, as well as methods of using them to treat a subject are also provided.

    Pharmaceutical formulations for sustained drug delivery
    9.
    发明申请
    Pharmaceutical formulations for sustained drug delivery 审中-公开
    用于持续给药的药物制剂

    公开(公告)号：US20070185033A1

    公开(公告)日：2007-08-09

    申请号：US11205270

    申请日：2005-08-15

    申请人： Malcolm Gefter ,  Nicholas Barker ,  Gary Musso ,  Christopher Molineaux

    发明人： Malcolm Gefter ,  Nicholas Barker ,  Gary Musso ,  Christopher Molineaux

    IPC分类号： A61K38/09 ,  A61K38/08 ,  A61K9/14

    CPC分类号： A61K9/146 ,  A61K9/0019 ,  A61K38/09

    摘要： Sustained delivery formulations comprising a water-insoluble complex of a peptidic compound (e.g., a peptide, polypeptide, protein, peptidomimetic or the like) and a carrier macromolecule are disclosed. The formulations of the invention allow for loading of high concentrations of peptidic compound in a small volume and for delivery of a pharmaceutically active peptidic compound for prolonged periods, e.g., one month, after administration of the complex. The complexes of the invention can be milled or crushed to a fine powder. In powdered form, the complexes form stable aqueous suspensions and dispersions, suitable for injection. In a preferred embodiment, the peptidic compound of the complex is an LHRH analogue, preferably an LHRH antagonist, and the carrier macromolecule is an anionic polymer, preferably carboxymethylcellulose. Methods of making the complexes of the invention, and methods of using LHRH-analogue-containing complexes to treat conditions treatable with an LHRH analogue, are also disclosed.

    摘要翻译： 公开了包含肽化合物（例如肽，多肽，蛋白质，拟肽等）和载体大分子的水不溶性络合物的持续递送制剂。 本发明的制剂允许在施用复合物之后将较高体积的肽化合物加载至少量的药物活性肽化合物延长的时期，例如一个月。 本发明的络合物可以研磨或粉碎成细粉末。 以粉末形式，络合物形成稳定的水性悬浮液和分散体，适于注射。 在优选的实施方案中，复合物的肽化合物是LHRH类似物，优选LHRH拮抗剂，载体大分子是阴离子聚合物，优选羧甲基纤维素。 还公开了制备本发明复合物的方法，以及使用含LHRH类似物的复合物治疗可用LHRH类似物治疗的病症的方法。

    Pharmaceutical formulations for sustained drug delivery
    10.
    发明授权
    Pharmaceutical formulations for sustained drug delivery 失效
    用于持续给药的药物制剂

    公开(公告)号：US06180608B2

    公开(公告)日：2001-01-30

    申请号：US08988851

    申请日：1997-12-11

    申请人： Malcolm L. Gefter ,  Nicholas Barker ,  Gary Musso ,  Christopher J. Molineaux

    发明人： Malcolm L. Gefter ,  Nicholas Barker ,  Gary Musso ,  Christopher J. Molineaux

    IPC分类号： A61K3800

    CPC分类号： B82Y5/00 ,  A61K38/09 ,  A61K47/61 ,  A61K47/6949 ,  Y10S514/80

    摘要： Sustained delivery formulations comprising a water-insoluble complex of a peptidic compound (e.g., a peptide, polypeptide, protein, peptidomimetic or the like) and a carrier macromolecule are disclosed. The formulations of the invention allow for loading of high concentrations of peptidic compound in a small volume and for delivery of a pharmaceutically active peptidic compound for prolonged periods, e.g., one month, after administration of the complex. The complexes of the invention can be milled or crushed to a fine powder. In powdered form, the complexes form stable aqueous suspensions and dispersions, suitable for injection. In a preferred embodiment, the peptidic compound of the complex is an LHRH analogue, preferably an LHRH antagonist, and the carrier macromolecule is an anionic polymer, preferably carboxymethylcellulose. Methods of making the complexes of the invention, and methods of using LHRH-analogue-containing complexes to treat conditions treatable with an LHRH analogue, are also disclosed.

    摘要翻译： 公开了包含肽化合物（例如肽，多肽，蛋白质，拟肽等）和载体大分子的水不溶性络合物的持续递送制剂。 本发明的制剂允许在施用复合物之后将较高体积的肽化合物加载至少量的药物活性肽化合物延长的时期，例如一个月。 本发明的络合物可以研磨或粉碎成细粉末。 以粉末形式，络合物形成稳定的水性悬浮液和分散体，适于注射。 在优选的实施方案中，复合物的肽化合物是LHRH类似物，优选LHRH拮抗剂，载体大分子是阴离子聚合物，优选羧甲基纤维素。 还公开了制备本发明复合物的方法，以及使用含LHRH类似物的复合物治疗可用LHRH类似物治疗的病症的方法。