公开(公告)号：US20100255999A1

公开(公告)日：2010-10-07

申请号：US12525394

申请日：2008-02-01

申请人： Constantine S. Mitsiades ,  Douglas W. McMillin ,  Joseph M. Negri ,  Nicholas Mitsiades ,  Kenneth C. Anderson

发明人： Constantine S. Mitsiades ,  Douglas W. McMillin ,  Joseph M. Negri ,  Nicholas Mitsiades ,  Kenneth C. Anderson

IPC分类号： C40B20/00 ,  C40B60/12 ,  C12N5/00 ,  C12N5/09

CPC分类号： G01N33/5008 ,  C12M35/08

摘要： The invention provides a cell co-culture for the selective evaluation of the response of a cell of interest in the co-culture, and methods of using the co-culture. The cell co-culture and the methods are suitable for large-scale/high throughput screening for compounds useful for affecting at least one biological function or event of at least one cell type in the co-culture. The invention further provides kits for using the screening assays.

摘要翻译： 本发明提供了用于选择性评估共培养中感兴趣的细胞的反应的细胞共培养物，以及使用共培养物的方法。 细胞共培养和方法适用于大规模/高通量筛选用于共同培养中至少一种生物学功能或至少一种细胞类型事件的化合物。 本发明还提供了使用筛选试验的试剂盒。

公开(公告)号：US20090233973A1

公开(公告)日：2009-09-17

申请号：US12474555

申请日：2009-05-29

申请人： Boris Lin ,  Kenneth C. Anderson ,  James Douglas Griffin

发明人： Boris Lin ,  Kenneth C. Anderson ,  James Douglas Griffin

IPC分类号： A61K31/427 ,  A61P35/00

CPC分类号： A61K31/427 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a method of treating a warm-blooded animal, especially a human, having myeloma, especially myeloma which is resistant to conventional cytotoxic chemotherapy, comprising administering to said animal a therapeutically effective amount of an epothilone, especially an epothilone of formula I to a combination comprising an epothilone, for simultaneous, separate or sequential use; and to a pharmaceutical composition and a commercial package comprising said combination.

摘要翻译： 本发明涉及一种治疗具有对常规细胞毒性化学疗法有抗性的骨髓瘤特别是骨髓瘤的温血动物，特别是人的方法，包括向所述动物施用治疗有效量的埃坡霉素，特别是式 我涉及包含埃坡霉素的组合，用于同时，分开或顺序使用; 以及包含所述组合的药物组合物和商业包装。

公开(公告)号：US20090170862A1

公开(公告)日：2009-07-02

申请号：US12393418

申请日：2009-02-26

申请人： Kenneth C. Anderson

发明人： Kenneth C. Anderson

IPC分类号： A61K31/501 ,  A61K31/496 ,  A61P35/00

CPC分类号： A61K31/53 ,  A61K31/501 ,  A61K31/57 ,  A61K2300/00

摘要： The present invention relates to the use of a c-kit inhibitor, especially a c-kit inhibitor of formula I, wherein the radicals and symbols have the meanings as defined in the specification, for the preparation of a medicament for the treatment of myeloma, in particular multiple myeloma, especially myeloma which is resistant to conventional chemotherapy; to a combination comprising a c-kit inhibitor and a compound effecting apoptosis of myeloma cells, preferably dexamethasone, for simultaneous, separate or sequential use; to methods of treating myeloma; and to a pharmaceutical composition comprising said combination.

摘要翻译： 本发明涉及c-kit抑制剂，特别是式I的c-kit抑制剂的用途，其中基团和符号具有本说明书中定义的含义，用于制备用于治疗骨髓瘤的药物， 特别是多发性骨髓瘤，特别是对常规化学疗法有抗性的骨髓瘤; 涉及包含c-kit抑制剂和影响骨髓瘤细胞凋亡的化合物（优选地塞米松）以用于同时，分开或顺序使用的组合; 治疗骨髓瘤的方法; 以及包含所述组合的药物组合物。