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公开(公告)号：US20080032334A1
公开(公告)日：2008-02-07
申请号：US11539103
申请日：2006-10-05
IPC分类号： C12P21/06
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
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公开(公告)号：US07910313B2
公开(公告)日：2011-03-22
申请号：US12890408
申请日：2010-09-24
CPC分类号： C07K14/56 , C12Q2600/158
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
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公开(公告)号：US20120142612A1
公开(公告)日：2012-06-07
申请号：US13353524
申请日：2012-01-19
CPC分类号： C07K14/56 , C12Q2600/158
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
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公开(公告)号：US20110195916A1
公开(公告)日：2011-08-11
申请号：US13028101
申请日：2011-02-15
CPC分类号： C07K14/56 , C12Q2600/158
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
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25.发明授权Method of using interferon-like protein ZCYTO20 (IL-28A) or ZCYTO22 (IL-28B) to treat hepatitis C 有权使用干扰素样蛋白ZCYTO20（IL-28A）或ZCYTO22（IL-28B）治疗丙型肝炎的方法公开(公告)号：US07655222B2
公开(公告)日：2010-02-02
申请号：US11868170
申请日：2007-10-05
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
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公开(公告)号：US07638305B2
公开(公告)日：2009-12-29
申请号：US11550652
申请日：2006-10-18
申请人： Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
发明人： Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
摘要翻译： 已经通过在编码成熟蛋白的多核苷酸序列中突变一个或多个半胱氨酸残基来产生IL-28A，IL-28B和IL-29的均质制剂。 可以显示半胱氨酸突变蛋白与其同源受体结合或表现出生物活性。 所示的一种生物活性是抗病毒活性。
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公开(公告)号：US07544779B2
公开(公告)日：2009-06-09
申请号：US11549531
申请日：2006-10-13
申请人： Lowell J. Brady , Kevin M. Klucher , Chung-leung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
发明人： Lowell J. Brady , Kevin M. Klucher , Chung-leung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
摘要翻译： 已经通过在编码成熟蛋白的多核苷酸序列中突变一个或多个半胱氨酸残基来产生IL-28A，IL-28B和IL-29的均质制剂。 可以显示半胱氨酸突变蛋白与其同源受体结合或表现出生物活性。 所示的一种生物活性是抗病毒活性。
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公开(公告)号：US07479542B2
公开(公告)日：2009-01-20
申请号：US11549760
申请日：2006-10-16
申请人： Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
发明人： Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
摘要翻译： 已经通过在编码成熟蛋白的多核苷酸序列中突变一个或多个半胱氨酸残基来产生IL-28A，IL-28B和IL-29的均质制剂。 可以显示半胱氨酸突变蛋白与其同源受体结合或表现出生物活性。 所示的一种生物活性是抗病毒活性。
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公开(公告)号：US08231866B2
公开(公告)日：2012-07-31
申请号：US13353524
申请日：2012-01-19
CPC分类号： C07K14/56 , C12Q2600/158
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
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30.发明授权Method of using interferon-like potein ZCYTO20 (IL-28A) or ZCYTO22(IL-28B) to treat hepatitis B 有权使用干扰素样potein ZCYTO20（IL-28A）或ZCYTO22（IL-28B）治疗乙型肝炎的方法公开(公告)号：US07829076B2
公开(公告)日：2010-11-09
申请号：US12630571
申请日：2009-12-03
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
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