公开(公告)号：US20240360108A1

公开(公告)日：2024-10-31

申请号：US18581307

申请日：2024-02-19

申请人： EISAI R&D MANAGEMENT CO., LTD.

发明人： Ermira PAZOLLI ,  Silvia BUONAMICI ,  Thiwanka SAMARAKOON ,  Sudeep PRAJAPATI ,  Nathan FISHKIN ,  James PALACINO ,  Michael SEILER ,  Ping ZHU ,  Andrew COOK ,  Peter SMITH ,  Xiang LIU ,  Shelby ELLERY ,  Dominic REYNOLDS ,  Lihua YU ,  Zhenhua WU ,  Shouyong PENG ,  Nicholas CALANDRA ,  Megan SHEEHAN ,  Yonghong XIAO

IPC分类号： C07D405/12 ,  A61K9/127 ,  A61K9/51 ,  A61K31/365 ,  A61K31/496 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/60 ,  A61K47/68 ,  A61P35/00 ,  C07D313/00 ,  C07D405/06 ,  C07K16/24 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  C07K16/40 ,  C12Q1/6886 ,  G01N33/50 ,  G01N33/574

CPC分类号： C07D405/12 ,  A61K9/127 ,  A61K9/51 ,  A61K31/365 ,  A61K31/496 ,  A61K39/0011 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/60 ,  A61K47/6845 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6857 ,  A61K47/6869 ,  A61K47/6871 ,  A61K47/6889 ,  A61P35/00 ,  C07D313/00 ,  C07D405/06 ,  C07K16/24 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2896 ,  C07K16/3007 ,  C07K16/3092 ,  C07K16/32 ,  C07K16/40 ,  C12Q1/6886 ,  G01N33/5011 ,  G01N33/574 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/545 ,  C07K2317/565 ,  C07K2317/76 ,  C12Q2600/106 ,  G01N2500/10

摘要： Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

公开(公告)号：US20240344025A1

公开(公告)日：2024-10-17

申请号：US18294854

申请日：2022-09-21

申请人： The Regents of the University of California

发明人： Wendell A. LIM ,  Nishith REDDY ,  Milos SIMIC

IPC分类号： C12N5/0783 ,  A61K35/17 ,  A61P37/06 ,  C07K14/54 ,  C07K14/55 ,  C07K14/705 ,  C07K16/24

CPC分类号： C12N5/0636 ,  A61K35/17 ,  A61P37/06 ,  C07K14/5428 ,  C07K14/55 ,  C07K14/70596 ,  C07K16/24 ,  C12N2510/00

摘要： Provided herein is a synthetic immuno-suppressive cell that contains comprises a molecular circuit comprising the following components: (a) a binding-triggered transcriptional switch (BTTS); and one or both of: (b) a nucleic acid encoding a pro-inflammatory cytokine sink, (c) a nucleic acid encoding an anti-inflammatory cytokine, (d) a nucleic acid encoding an immune inhibitory receptor, or ligand thereof, and (c) a nucleic acid encoding an ectonucleotidase. In this circuit, binding of the BTTS to a marker on the surface of a target cell activates expression of one or any combination of (b)-(c) by the synthetic immuno-suppressive cell.

公开(公告)号：US12103967B2

公开(公告)日：2024-10-01

申请号：US18509252

申请日：2023-11-14

申请人： Hoffmann-La Roche Inc.

发明人： Jens Fischer ,  Guy Georges ,  Anton Jochner ,  Gregor Jordan ,  Hubert Kettenberger ,  Joerg Moelleken ,  Tilman Schlothauer ,  Georg Tiefenthaler ,  Valeria Runza ,  Meher Majety ,  Martin Schaefer ,  Maria Viert ,  Shu Feng ,  Wei Shiong Adrian Ho ,  Siok Wan Gan ,  Runyi Adeline Lam ,  Michael Gertz

IPC分类号： C07K16/46 ,  A61K39/385 ,  C07K16/24 ,  C12N5/00 ,  C12N15/09 ,  A61K39/00 ,  C12N5/07 ,  C12N15/63

CPC分类号： C07K16/24 ,  A61K39/385 ,  A61K2039/505 ,  C07K16/46 ,  C07K2317/31 ,  C07K2317/565 ,  C12N5/06 ,  C12N15/09 ,  C12N15/63

摘要： The present invention relates to bispecific anti-CCL2 antibodies binding to two different epitopes on human CCL2, pharmaceutical compositions thereof, their manufacture, and use as medicaments for the treatment of cancers, inflammatory, autoimmune and ophthalmologic diseases.

公开(公告)号：US12084493B2

公开(公告)日：2024-09-10

申请号：US16994882

申请日：2020-08-17

申请人： Washington State University

发明人： Santanu Bose ,  Philippe Tessier

IPC分类号： A61K39/395 ,  C07K16/24 ,  A61K39/00

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/76

摘要： The present disclosure provides methods of treating a pathogen-induced lung inflammation in a subject are provided in which an anti-S100A9 antibody is administered to a subject. Methods of treating a respiratory virus infection by administering an anti-S100A9 antibody are also provided.

公开(公告)号：US12077579B2

公开(公告)日：2024-09-03

申请号：US17475214

申请日：2021-09-14

申请人： Neuracle Science Co., Ltd.

发明人： Bongcheol Kim ,  Jae-Keun Lee ,  Dong Sik Kim

IPC分类号： G01N33/53 ,  C07K16/24 ,  G01N33/68 ,  A61K39/00

CPC分类号： C07K16/24 ,  G01N33/6863 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76

摘要： The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to treat or to diagnose a fibrosis and/or a fibrosis-associated disease in a subject in need thereof.

公开(公告)号：US20240279326A1

公开(公告)日：2024-08-22

申请号：US18594234

申请日：2024-03-04

申请人： Pfizer Inc. ,  The Regents of the University of California

发明人： Rachel Groth ,  William Brian Snyder ,  Xianjun Cao ,  Robert J. Dunn ,  Joseph Dal Porto ,  Michael Karin

IPC分类号： C07K16/24 ,  A61K39/00 ,  A61P19/02 ,  A61P37/06 ,  C07K16/28 ,  C07K16/40 ,  C12N15/62

CPC分类号： C07K16/24 ,  A61P19/02 ,  A61P37/06 ,  C07K16/2866 ,  C07K16/40 ,  C12N15/62 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/92 ,  C07K2317/94

摘要： The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to CXCR5. The antibodies can be afucosylated and exhibit increased ADCC compared with the otherwise identical fucosylated antibodies. The invention includes uses, and associated methods of using the antibodies.

公开(公告)号：US12037387B2

公开(公告)日：2024-07-16

申请号：US17284611

申请日：2019-10-15

申请人： Eli Lilly and Company

发明人： Kristine Kay Kikly ,  Dipak Ratilal Patel ,  Derrick Ryan Witcher

IPC分类号： C07K16/24 ,  A61K9/00 ,  A61P17/00 ,  A61K39/00

CPC分类号： C07K16/24 ,  A61K9/0019 ,  A61P17/00 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： Provided herein are methods and uses of antibodies against ELR+ CXC chemokines for the treatment of hidradenitis suppurativa. Also provided are doses and dosing regimens for the methods and uses of antibodies against ELR+ CXC chemokines for the treatment of hidradenitis suppurativa.

公开(公告)号：US12030935B2

公开(公告)日：2024-07-09

申请号：US17583930

申请日：2022-01-25

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Yinglin Gao ,  Scott Macdonnell ,  Bharathi Sundaram ,  Jee Kim ,  Isabella Del Priore ,  Jake Megna ,  Qin Ruan ,  Lori C. Morton

IPC分类号： A61K39/395 ,  A61P9/12 ,  A61P43/00 ,  C07K16/22 ,  C07K16/24

CPC分类号： C07K16/22 ,  A61P9/12 ,  A61P43/00 ,  C07K16/24 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/76

摘要： The present disclosure provides anti-Platelet-Derived Growth Factor Subunit B (PDGF-B) antibodies, and antigen-binding fragments thereof, as well as methods of use of such antibodies, or antigen-binding fragments thereof, for treating a subject having pulmonary arterial hypertension (PAH).

公开(公告)号：US12024568B2

公开(公告)日：2024-07-02

申请号：US14426347

申请日：2013-09-13

申请人： Ronald G. Crystal ,  Stephen M. Kaminsky ,  Martin J. Hicks ,  Viviane Tabar

发明人： Ronald G. Crystal ,  Stephen M. Kaminsky ,  Martin J. Hicks ,  Viviane Tabar

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61K48/00 ,  C07K16/22 ,  C07K16/24 ,  C07K16/30

CPC分类号： C07K16/3053 ,  A61K48/005 ,  C07K16/22 ,  C07K16/24 ,  C07K16/2863 ,  A61K2039/505 ,  A61K48/00 ,  C07K2317/21 ,  C07K2317/24 ,  C12N2750/14141 ,  C12N2799/025

摘要： The invention provides methods to inhibit or treat brain cancers by locally inhibiting expression or activity of growth factors or growth factor receptors.

公开(公告)号：US20240166735A1

公开(公告)日：2024-05-23

申请号：US18350287

申请日：2023-07-11

申请人： Neuracle Science Co., Ltd.

发明人： Jae Young SEONG ,  Jong Ik HWANG ,  Woong SUN ,  Eun Bee CHO ,  Won-Ki KIM

IPC分类号： C07K16/24 ,  A61K38/17 ,  A61K48/00 ,  C07K14/47 ,  C07K16/18 ,  C12N15/113 ,  C12Q1/6886 ,  G01N33/577 ,  G01N33/68 ,  A61K39/00

CPC分类号： C07K16/24 ,  A61K38/1709 ,  A61K48/00 ,  C07K14/4701 ,  C07K14/4702 ,  C07K16/18 ,  C12N15/113 ,  C12Q1/6886 ,  G01N33/577 ,  G01N33/6896 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/76 ,  C12N2310/11 ,  C12N2310/141 ,  C12Q2600/156 ,  G01N2333/47

摘要： The present invention relates to the pharmaceutical use of FAM19A5 involved in regulating gliogenesis, and more specifically, to the use of FAM19A5 in the prevention, diagnosis, or treatment of central nervous system injuries, degenerative brain diseases, or central nervous system diseases, FAM19A5 being spread in the neural stem cells in vertebrates and regulating gliogenesis.