公开(公告)号：US6013652A

公开(公告)日：2000-01-11

申请号：US985338

申请日：1997-12-04

申请人： Malcolm Maccoss ,  Sander G. Mills ,  Shrenik K. Shah ,  Yuan-Ching P. Chiang ,  Patrick T. Dunn ,  Hiroo Koyama

发明人： Malcolm Maccoss ,  Sander G. Mills ,  Shrenik K. Shah ,  Yuan-Ching P. Chiang ,  Patrick T. Dunn ,  Hiroo Koyama

IPC分类号： C07D471/10 ,  C07D491/10 ,  C07D495/10 ,  A61K31/44 ,  C07D401/02

CPC分类号： C07D471/10 ,  C07D491/10 ,  C07D495/10

摘要： Disclosed are spiro-substituted azacycles of formula I are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma. In particular compounds of formula I are shown to be neurokinin antagonists.

摘要翻译： 公开的式I的螺取代的azacycles是可用于治疗炎性疾病，疼痛或偏头痛和哮喘的速激肽受体拮抗剂。 特别地，式I化合物显示为神经激肽拮抗剂。

公开(公告)号：US5592570A

公开(公告)日：1997-01-07

申请号：US348956

申请日：1994-11-28

申请人： Hiroo Koyama

发明人： Hiroo Koyama

IPC分类号： G06T11/20 ,  G09G5/20 ,  G09G5/28 ,  G06K9/40

CPC分类号： G09G5/20 ,  G06T11/203 ,  G09G5/28

摘要： In this invention, an original image is read to be formed as a tour bit map, and the bit map is read out for each plurality of picture elements. Then, in the position to which the aforementioned unit plurality of picture elements corresponds on the original image, a predetermined bit map data is to be written by a logical sum. If the operation is indicated as a shadowing process, a bit map of a predetermined oblique line for a shadow designated by a direction and a length is to be written. The aforementioned operation is carried out for every plurality of picture elements on the contour bit map so as to thicken or shadow the original image at a high speed. When the method of this invention is applied as to a large size region, since the work area for the reservation of the contour data becomes larger to exhibit less effectiveness of the space usage, the processing area is designed to be divided, if required, to be processed. In such a division method, it is required to set up as work areas a reservation area for keeping the contour bit map and a writing-in region for writing in the synthetic unit data in the use of the logical sum. Providing the latter mentioned writing-in region makes it possible to save a clipping treatment, and also give an advantage for effecting the thinning operation.

摘要翻译： 在本发明中，原始图像被读取以形成为旅游位图，并且针对每个多个图像元素读出位图。 然后，在上述单位多个像素对应于原始图像的位置，将通过逻辑和写入预定位图数据。 如果操作被指示为阴影处理，则将写入由方向和长度指定的阴影的预定斜线的位图。 对轮廓位图上的每个多个像素执行上述操作，以便以高速增厚或影印原始图像。 当将本发明的方法应用于大尺寸区域时，由于用于保留轮廓数据的工作区域变大以表现出较小的空间使用效率，因此如果需要，处理区域被设计成被划分为 被处理。 在这种分割方法中，需要在使用逻辑和的情况下将用于保持轮廓位图的预留区域和写入合成单位数据的写入区域设置为工作区域。 提供后面提到的写入区域使得可以节省削波处理，并且还具有实现稀疏操作的优点。

公开(公告)号：US5355421A

公开(公告)日：1994-10-11

申请号：US944940

申请日：1992-09-15

申请人： Hiroo Koyama

发明人： Hiroo Koyama

IPC分类号： G06T5/00 ,  H04N1/409 ,  G06K9/40 ,  G06K9/48

CPC分类号： H04N1/409

摘要： A method for identifying and removing noise from digitized images includes the steps for judging whether or not a group of black pixels represents a noise by analyzing the number of pixels in the group, the degree of flattening of the group and the curvature of the region. According to the inventive method, since the entire region is scanned at once, allowing the detection of various sized pixel groups, the black pixel groups meeting a predetermined level can be selected and removed from a corresponding predefined region. Thus, noise can be removed from several predefined regions using a different noise level for each region.

摘要翻译： 用于从数字化图像中识别和去除噪声的方法包括以下步骤：通过分析组中的像素数量，组的平坦度和区域的曲率来判断一组黑色像素是否表示噪声。 根据本发明的方法，由于整个区域被一次扫描，允许检测各种尺寸的像素组，所以可以从相应的预定区域中选择和去除满足预定水平的黑色像素组。 因此，可以使用针对每个区域的不同噪声电平从若干预定区域去除噪声。