专利检索 cpc:"C07D491/10" 第 1 页

1.

发明授权
Alpha-cinnamide compounds and compositions as HDAC8 inhibitors 有权

公开(公告)号：US11919839B2

公开(公告)日：2024-03-05

申请号：US17238529

申请日：2021-04-23

申请人： Valo Health, Inc.

发明人： Kenneth W. Bair , Nicholas Barczak , Bingsong Han , David R. Lancia, Jr. , Cuixian Liu , Matthew W. Martin , Pui Yee Ng , Aleksandra Rudnitskaya , Jennifer R. Thomason , Mary-Margaret Zablocki , Xiaozhang Zheng

IPC分类号： C07C259/06 , A61K31/185 , A61K31/277 , A61K31/397 , A61K31/4035 , A61K31/407 , A61K31/417 , A61K31/4184 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/4439 , A61K31/451 , A61K31/495 , A61K31/5377 , C07D207/10 , C07D207/267 , C07D209/08 , C07D209/42 , C07D209/44 , C07D209/46 , C07D211/16 , C07D211/58 , C07D213/56 , C07D213/65 , C07D213/75 , C07D213/81 , C07D215/12 , C07D221/20 , C07D231/14 , C07D231/18 , C07D233/36 , C07D233/38 , C07D233/68 , C07D235/14 , C07D235/30 , C07D239/20 , C07D239/22 , C07D241/08 , C07D241/12 , C07D249/18 , C07D257/04 , C07D261/18 , C07D277/56 , C07D295/155 , C07D295/192 , C07D307/68 , C07D317/68 , C07D333/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D493/08 , C07D495/10 , C07D498/04 , C07D513/10

CPC分类号： C07C259/06 , A61K31/185 , A61K31/277 , A61K31/397 , A61K31/4035 , A61K31/407 , A61K31/417 , A61K31/4184 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/4439 , A61K31/451 , A61K31/495 , A61K31/5377 , C07D207/10 , C07D207/267 , C07D209/08 , C07D209/42 , C07D209/44 , C07D209/46 , C07D211/16 , C07D211/58 , C07D213/56 , C07D213/65 , C07D213/75 , C07D213/81 , C07D215/12 , C07D221/20 , C07D231/14 , C07D231/18 , C07D233/36 , C07D233/38 , C07D233/68 , C07D235/14 , C07D235/30 , C07D239/20 , C07D239/22 , C07D241/08 , C07D241/12 , C07D249/18 , C07D257/04 , C07D261/18 , C07D277/56 , C07D295/155 , C07D295/192 , C07D307/68 , C07D317/68 , C07D333/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D493/08 , C07D495/10 , C07D498/04 , C07D513/10 , Y02A50/30

摘要： The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

2.

发明申请
QUINOXALINE AND PYRIDOPYRAZINE DERIVATIVES AS PI3KB INHIBITORS 审中-公开

公开(公告)号：US20190062311A1

公开(公告)日：2019-02-28

申请号：US15766887

申请日：2016-10-07

申请人： Janssen Pharmaceutica NV

发明人： Patrick Rene Angibaud , Olivier Alexis Georges Querolle , Didier Jean-Claude Berthelot , Christophe Meyer , Matthieu Philippe Victor Willot , Lieven Meerpoel , Thierry Francois Alain Jean Jousseaume

IPC分类号： C07D403/10 , C07D487/04 , C07D495/10 , C07D498/10 , C07D471/04 , C07D241/42 , C07D403/12 , C07D403/14 , C07D413/10

CPC分类号： C07D403/10 , C07D241/14 , C07D241/42 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D471/04 , C07D487/02 , C07D487/04 , C07D491/10 , C07D495/10 , C07D498/10 , C07D513/10

摘要： The present invention relates to substituted quinoxaline and pyridopyrazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3Kβ inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

3.

发明申请
NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES 审中-公开

公开(公告)号：US20180305352A1

公开(公告)日：2018-10-25

申请号：US15769414

申请日：2016-10-25

申请人： MERCK SHARP & DOHME CORP.

发明人： David J. Witter , Tesfaye Biftu , Purakkattle Biju , Stephane L. Bogen , Qingmei Hong , Chunhui Huang , Xianhai Huang , Bing Li , Min K. Park , David L. Sloman

IPC分类号： C07D471/04 , C07D519/00 , A61P35/02

CPC分类号： C07D471/04 , A61P35/02 , C07D491/10 , C07D498/08 , C07D519/00

摘要： The present invention is directed to tricyclic compounds of formula (I), (Ia) or (Ib) which are inhibitors of one or more mutant IDH enzymes. The present invention is also directed to uses of these tricyclic compounds in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.

4.

发明申请
1-PYRAZOLYL-3- (4- ((2 -ANILINOPYRIMIDIN- 4 - YL) OXY) NAPTHTHALEN- I - YL) UREAS AS P38 MAPKINASE INHIBITORS 审中-公开

公开(公告)号：US20180134687A1

公开(公告)日：2018-05-17

申请号：US15812425

申请日：2017-11-14

申请人： RESPIVERT LIMITED

发明人： Kazuhiro Ito , Catherine Elisabeth Charron , John King-Underwood , Stuart Thomas Onions , Alistair Ian Longshaw , Rudy Broeckx , Walter Filliers , Alex Copmans

IPC分类号： C07D403/12 , A61K31/351 , A61K31/513 , A61K31/506 , A61K31/215 , C07D491/10 , A61K31/4155

CPC分类号： C07D403/12 , A61K31/215 , A61K31/351 , A61K31/4155 , A61K31/506 , A61K31/513 , C07B2200/13 , C07D491/10 , Y02A50/406

摘要： There is provided a compound of formula (I) which is an inhibitor of the family of p38 mitogen-activated protein kinase enzymes, and to its use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as asthma and COPD.

5.

发明授权
Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors 有权

公开(公告)号：US09944625B2

公开(公告)日：2018-04-17

申请号：US15361589

申请日：2016-11-28

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Michael J. Orwat , Donald J. P. Pinto , Leon M. Smith, II , Shefali Srivastava

IPC分类号： C07D401/14 , C07D413/14 , C07D217/26 , C07D401/04 , C07D401/10 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D491/113 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , C07D491/107

CPC分类号： C07D401/14 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P7/02 , C07B2200/13 , C07D217/26 , C07D401/04 , C07D401/10 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D491/107 , C07D491/113

摘要： The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.

6.

发明申请
SUBSTITUTED ALIPHANES, CYCLOPHANES, HETERAPHANES, HETEROPHANES, HETERO-HETERAPHANES AND METALLOCENES USEFUL FOR TREATING HCV INFECTIONS 审中-公开

公开(公告)号：US20180055824A1

公开(公告)日：2018-03-01

申请号：US15804842

申请日：2017-11-06

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan Wiles , Qiuping Wang , Akihiro Hashimoto , Godwin Pais , Xiangzhu Wang , Venkat Gadhachanda , Avinash Phadke , Milind Deshpande , Dawei Chen

IPC分类号： A61K31/4184 , C07F17/02 , C07D401/14 , C07D209/42 , C07D403/04 , A61K9/20 , A61K9/00 , C07F15/02 , A61K31/427 , A61K31/454 , C07D453/06 , C07D491/113 , A61K31/422 , C07F5/02 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D491/10 , C07D519/00 , A61K45/06 , A61K31/4178 , A61K31/555 , A61K31/496 , A61K31/439

CPC分类号： A61K31/4184 , A61K9/0053 , A61K9/20 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/439 , A61K31/454 , A61K31/496 , A61K31/555 , A61K45/06 , A61K2300/00 , C07D209/42 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/14 , C07D417/14 , C07D453/06 , C07D471/08 , C07D491/10 , C07D491/113 , C07D519/00 , C07F5/025 , C07F15/02 , C07F17/02

摘要： The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula I D-M-D (Formula I) useful as antiviral agents. In certain embodiments disclosed herein M is a group —P-A-P— where A is Certain substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions/and combinations containing one or more substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes and a pharmaceutically acceptable carrier are also provided by this disclosure. Methods for treating viral infections, including Hepatitis C viral infections are provided by the disclosure.

7.

发明授权
FLAP modulators 有权

公开(公告)号：US09884878B2

公开(公告)日：2018-02-06

申请号：US14728128

申请日：2015-06-02

申请人： JANSSEN PHARMACEUTICA NV

发明人： Genesis M. Bacani , Wendy Eccles , Anne E. Fitzgerald , Steven D. Goldberg , Michael D. Hack , Natalie A. Hawryluk , William M. Jones , John M. Keith , Paul Krawczuk , Alec D. Lebsack , Alice Lee-Dutra , Jing Liu , Kelly J. McClure , Steven P. Meduna , Daniel J. Pippel , Mark D. Rosen , Zachary S. Sales

IPC分类号： C07D241/20 , A61K31/4965 , C07F7/08 , C07D241/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D487/04 , C07D405/14 , C07D413/14 , C07D213/73 , C07D401/04 , C07D235/10 , C07D401/10 , C07D403/10 , C07D237/20 , C07D409/12 , C07D413/10 , C07D417/10 , C07D471/04 , C07D487/08 , C07D263/48 , C07D491/10 , C07D498/04 , C07D209/08 , C07D277/62 , C07D285/12 , C07F5/02 , C07D403/14 , C07D405/12 , C07D491/08 , C07D491/107 , C07D495/10

CPC分类号： C07F7/0812 , C07D209/08 , C07D213/73 , C07D235/10 , C07D237/20 , C07D241/20 , C07D241/26 , C07D263/48 , C07D277/62 , C07D285/12 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10 , C07D491/107 , C07D495/10 , C07D498/04 , C07F5/025 , C07F7/08

摘要： The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R1, R2, R3, R3′, L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

8.

发明授权
Substituted spirocycles 有权

公开(公告)号：US09879026B2

公开(公告)日：2018-01-30

申请号：US15362949

申请日：2016-11-29

申请人： Boehringer Ingelheim International GmbH

发明人： Viktor Vintonyak , Matthias Grauert , Marc Grundl , Alexander Pautsch

IPC分类号： C07D215/00 , A61K31/47 , C07D491/20 , A61K45/06 , C07D471/08 , C07D519/00 , C07D471/10 , C07D491/10 , A61K31/435 , A61K31/4355 , A61K31/438 , C07D401/12 , C07D487/10 , C07D491/107

CPC分类号： C07D491/20 , A61K31/435 , A61K31/4355 , A61K31/438 , A61K45/06 , C07D401/12 , C07D471/08 , C07D471/10 , C07D487/10 , C07D491/10 , C07D491/107 , C07D519/00

摘要： This invention relates to a compound of formula I wherein A and Cy have one of the meanings as indicated in the specification and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.