公开(公告)号：US5195963A

公开(公告)日：1993-03-23

申请号：US820565

申请日：1992-01-14

申请人： Masao Yafuso ,  Laurence A. Harker

发明人： Masao Yafuso ,  Laurence A. Harker

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1459 ,  A61M25/00

CPC分类号： A61B5/6852 ,  A61B5/14539 ,  A61B5/1459

摘要： A method for determining the concentration of a constituent of blood employing a sensor in or near a catheter in a blood vessel for producing a signal related to the concentration of the constituent of blood is disclosed. The improvement comprises obtaining the signal while at least one of the following is present in the blood vessel: (1) an added vasodilator component and/or vasodilation promotor in an amount effective to reduce the vasoconstriction caused by the presence of the catheter in the blood vessel and (2) an added platelet/white cell inhibitor component and/or a platelet/white cell deactivation promotor in an amount effective to reduce the platelet and/or white cell activation caused by the presence of the catheter in the blood vessel.

摘要翻译： 公开了一种用于确定在血管中的导管内或其附近使用传感器的血液成分浓度的方法，用于产生与血液成分浓度相关的信号。 该改进包括获得信号，而在血管中存在以下至少之一：（1）添加的血管扩张剂组分和/或血管扩张启动子，其量可以有效地减少由导管在血液中的存在而引起的血管收缩 血管和（2）增加的血小板/白细胞抑制剂组分和/或血小板/白细胞去激活启动子，其量可以有效地减少由导管在血管中的存在引起的血小板和/或白细胞活化。

公开(公告)号：US5081042A

公开(公告)日：1992-01-14

申请号：US496561

申请日：1990-03-20

申请人： Masao Yafuso ,  Chong F. Yan

发明人： Masao Yafuso ,  Chong F. Yan

IPC分类号： G01N21/64 ,  G01N21/77 ,  G01N31/22

CPC分类号： G01N31/221 ,  G01N21/6428 ,  G01N2021/6434 ,  G01N2021/7786

摘要： A composition of matter useful in a sensor for sensing the concentration of an ionic component a medium is disclosed. This composition comprises a first material including a sensing component in an amount effective to provide a signal which varies as the concentration of the ionic component in the medium varies, and a first matrix material, and a second material which includes a second matrix material which is compatible with the first matrix material, and an opague agent in an amount sufficient to render the second material effectively opaque. The first material and the second material are partially intermingled. Apparatus including such composition of matter and methods for making and using such compositions of matter are also disclosed.

摘要翻译： 公开了用于感测介质中的离子组分的浓度的传感器中的物质组合物。 该组合物包括第一材料，其包括感测组分，其量有效地提供随着介质中离子组分的浓度变化而变化的信号，以及第一基质材料，以及第二材料，其包括第二基质材料， 与第一基质材料相容，以及足以使第二材料有效不透明的量的op剂。 第一种材料和第二种材料是部分混合的。 还公开了包括这种物质组成的装置和用于制造和使用这种物质组合物的方法的装置。

公开(公告)号：US5081041A

公开(公告)日：1992-01-14

申请号：US503838

申请日：1990-04-03

申请人： Masao Yafuso ,  Evan A. Thompson ,  John L. Dektar ,  James F. Fagan ,  Sanjay L. Patil

发明人： Masao Yafuso ,  Evan A. Thompson ,  John L. Dektar ,  James F. Fagan ,  Sanjay L. Patil

IPC分类号： G01N31/22 ,  G01N21/80 ,  G01N33/84

CPC分类号： G01N33/84 ,  G01N21/80 ,  G01N2021/6434 ,  G01N21/6428

摘要： A composition of matter useful in a sensor for sensing the concentration of an ionic component in a medium is disclosed. This composition comprises a first material which includes a sensing component in an amount effective to provide a signal which varies as the concentration of the ionic component in the medium varies, and a first matrix material which is permeable to the ionic component; and a second material which includes a second matrix material which is permeable to the ionic component, and an opaque agent in an amount sufficient to render the second material effectively opaque. The first material matrix and the second matrix material are covalently bonded together. Sensing apparatus including such composition of matter and methods for making and using such composition of matter are also disclosed.

公开(公告)号：US4867919A

公开(公告)日：1989-09-19

申请号：US302832

申请日：1989-01-26

申请人： Masao Yafuso ,  John K. Suzuki

发明人： Masao Yafuso ,  John K. Suzuki

IPC分类号： A61B5/00 ,  G01N21/64 ,  G01N21/81 ,  G01N31/22

CPC分类号： G01N21/643 ,  A61B5/1459 ,  G01N31/223 ,  G01N2021/6434 ,  G01N21/81

摘要： A method for preparing a gas sensor includes forming a mixture containing an aqueous buffer solution including a dissolved dye, a polymeric precursor of a cross-linked polymeric material, and a cross-linking agent and reacting the polymeric precursor and the cross-linking agent in the mixture to form a gas sensor including micro-compartments of the aqueous buffer solution dispersed in the cross-linked polymeric material.

摘要翻译： 制备气体传感器的方法包括形成含有包含溶解的染料的水性缓冲溶液，交联聚合物材料的聚合物前体和交联剂的混合物，并使聚合物前体和交联剂在 所述混合物形成气体传感器，包括分散在交联聚合物材料中的缓冲溶液水溶液的微室。

公开(公告)号：US4824789A

公开(公告)日：1989-04-25

申请号：US917912

申请日：1986-10-10

申请人： Masao Yafuso ,  John K. Suzuki

发明人： Masao Yafuso ,  John K. Suzuki

IPC分类号： A61B5/00 ,  G01N21/64 ,  G01N21/77 ,  G01N21/81 ,  G01N31/22 ,  G01N33/49 ,  G02B6/02

CPC分类号： G01N21/7703 ,  A61B5/1459 ,  G01N21/6428 ,  G01N31/223 ,  G01N2021/6434 ,  G01N2021/772 ,  G01N2021/773 ,  G01N21/81 ,  Y10T436/204998

摘要： A gas sensor has a first aqueous phase. The aqueous phase is composed of a soluble dye in a buffer. One or more additional agent can be further added to the aqueous phase as for instance an emulisification enhancement agent. The aqueous phase is homogenized into a polymeric precursor forming a emulsion of the aqueous phase in the polymeric precursor. A catalyst and a cross-linking agent are added and the polymeric precursor material allowed to polymerize to form an emulsoid of micro-compartments of the aqueous phase in a polymeric second phase. The micro-compartments of the aqueous phase are dispersed through and permanently suspended in the polymeric second phase.

摘要翻译： 气体传感器具有第一水相。 水相由缓冲液中的可溶性染料组成。 可以将一种或多种另外的试剂进一步加入到水相中，例如增殖剂。 将水相均化成聚合物前体，形成聚合物前体中水相的乳液。 加入催化剂和交联剂，并使聚合物前体材料聚合以在聚合物第二相中形成水相的微室的乳液。 水相的微室分散通过永久悬浮在聚合物第二相中。