公开(公告)号：US4870175A

公开(公告)日：1989-09-26

申请号：US253546

申请日：1988-10-05

申请人： Yukio Suzuki ,  Masao Yaso ,  Katumi Nisimura ,  Kenzi Saeki ,  Noriyasu Takayanagi ,  Tetsu Saito ,  Eiichi Hayashi

发明人： Yukio Suzuki ,  Masao Yaso ,  Katumi Nisimura ,  Kenzi Saeki ,  Noriyasu Takayanagi ,  Tetsu Saito ,  Eiichi Hayashi

IPC分类号： A61K31/495 ,  A61P7/02 ,  C07D241/44 ,  C07D403/12

CPC分类号： C07D403/12 ,  C07D241/44

摘要： A compound of the formula ##STR1## wherein Z is N or NH, is a single or double bond, R.sub.1 is hydrogen, C.sub.1-20 alkyl or optionally substituted phenyl, A is lower alkylene, R is carboxyl, lower alkoxycarbonyl, ##STR2## or 1-cycloalkyl-tetrazole-5-yl, R.sub.2 is lower alkyl, hydroxy-lower alkyl or optionally substituted phenyl-lower alkyl, R.sub.3 is lower alkyl or cycloalkyl, or R.sub.2 and R.sub.3 together constitute ##STR3## and R.sub.5 and R.sub.6 are hydrogen or optionally substituted phenyl, or a pharmacologically acceptable salt thereof, has platelet aggregation inhibitory activity and/or cyclic AMP/phosphodiesterase inhibitory activity.

公开(公告)号：US20050159355A1

公开(公告)日：2005-07-21

申请号：US11012199

申请日：2004-12-16

申请人： Masazumi Kamohara ,  Mitsuyuki Matsumoto ,  Jun Takasaki ,  Tetsu Saito ,  Takahide Ohishi

发明人： Masazumi Kamohara ,  Mitsuyuki Matsumoto ,  Jun Takasaki ,  Tetsu Saito ,  Takahide Ohishi

IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C12N1/19 ,  C12N1/21 ,  C12N15/12 ,  A61K38/17 ,  C07H21/04 ,  C12Q1/68

CPC分类号： C07K14/723 ,  A61K38/00 ,  C07K14/705

摘要： This invention provides a nucleic acid encoding a novel leukotriene B4 receptor, a vector containing this nucleic acid, a method for screening a substance capable of modifying the activity of the receptor by using a host cell containing the vector and the receptor, and pharmaceutical compositions for inflammatory diseases containing as the active ingredient a substance capable of modifying the activity of the receptor.

摘要翻译： 本发明提供编码新型白三烯B4受体的核酸，含有该核酸的载体，通过使用含有载体​​和受体的宿主细胞筛选能够改变受体活性的物质的方法，以及用于 含有能够改变受体活性的物质作为活性成分的炎性疾病。

公开(公告)号：US20050042683A1

公开(公告)日：2005-02-24

申请号：US10898329

申请日：2004-07-26

申请人： Mitsuyuki Matsumoto ,  Toru Sugimoto ,  Jun Takasaki ,  Masazumi Kamohara ,  Tetsu Saito ,  Masato Kobayashi

发明人： Mitsuyuki Matsumoto ,  Toru Sugimoto ,  Jun Takasaki ,  Masazumi Kamohara ,  Tetsu Saito ,  Masato Kobayashi

IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C12N15/12 ,  G01N33/53 ,  C07H21/04

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/705 ,  C07K14/723

摘要： This invention belongs to the genetic engineering field, and provides novel G protein-coupled receptor family proteins SREB1, SREB2 and SREB3 expressed in the central nervous system, genes coding for these proteins, screening methods using these proteins and so on. As one of the methods for obtaining the G protein-coupled receptor proteins of the present invention, RT-PCR is carried out using mRNA extracted from human or rat brain tissue or brain-derived cells as the template and using two primers interposing the entire portion or a part of the G protein-coupled receptor protein translation region, thereby obtaining cDNA corresponding to the G protein-coupled receptor protein or a part thereof, and the cDNA is integrated into an appropriate expression vector and expressed in a host cell.

摘要翻译： 本发明属于遗传工程领域，提供了在中枢神经系统中表达的新型G蛋白偶联受体家族蛋白SREB1，SREB2和SREB3，编码这些蛋白质的基因，使用这些蛋白质的筛选方法等。 作为获得本发明的G蛋白偶联受体蛋白质的方法之一，使用从人或大鼠脑组织或脑源性细胞提取的mRNA作为模板，使用插入整个部分的两个引物进行RT-PCR 或G蛋白偶联受体蛋白质翻译区的一部分，从而获得对应于G蛋白偶联受体蛋白或其一部分的cDNA，并将cDNA整合到合适的表达载体中并在宿主细胞中表达。

公开(公告)号：US06808899B2

公开(公告)日：2004-10-26

申请号：US10318142

申请日：2002-12-13

申请人： Mitsuyuki Matsumoto ,  Toru Sugimoto ,  Jun Takasaki ,  Masazumi Kamohara ,  Tetsu Saito ,  Masato Kobayashi

发明人： Mitsuyuki Matsumoto ,  Toru Sugimoto ,  Jun Takasaki ,  Masazumi Kamohara ,  Tetsu Saito ,  Masato Kobayashi

IPC分类号： C12P2300

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/705 ,  C07K14/723

摘要： This invention belongs to the genetic engineering field, and provides novel G protein-coupled receptor family proteins SREB1, SREB2 and SREB3 expressed in the central nervous system, genes coding for these proteins, screening methods using these proteins and so on. As one of the methods for obtaining the G protein-coupled receptor proteins of the present invention, RT-PCR is carried out using mRNA extracted from human or rat brain tissue or brain-derived cells as the template and using two primers interposing the entire portion or a part of the G protein-coupled receptor protein translation region, thereby obtaining cDNA corresponding to the G protein-coupled receptor protein or a part thereof, and the cDNA is integrated into an appropriate expression vector and expressed in a host cell.

公开(公告)号：US5200415A

公开(公告)日：1993-04-06

申请号：US783869

申请日：1991-10-29

申请人： Takeo Higashino ,  Yukio Suzuki ,  Takehiko Sasahara ,  Tetsu Saito ,  Daisuke Mochizuki

发明人： Takeo Higashino ,  Yukio Suzuki ,  Takehiko Sasahara ,  Tetsu Saito ,  Daisuke Mochizuki

IPC分类号： C07D519/00

CPC分类号： C07D519/00

摘要： Described herein are pyrazolo[1,5-a]pyridine-3-carboxylic acid derivatives represented by the following formula (I): ##STR1## wherein R.sub.1 and R.sub.2 individually mean a hydrogen atom or a lower alkyl group, R.sub.3 denotes an azabicyclo group containing a tertiary nitrogen atom, and Y stands for --O-- or --NH--, or salts thereof. Their preparation process and serotonin receptor antagonists containing them as active ingredients are also described.