公开(公告)号：US08536134B2

公开(公告)日：2013-09-17

申请号：US11679934

申请日：2007-02-28

申请人： James N. Chang ,  Orest Olejnik ,  Bruce A. Firestone

发明人： James N. Chang ,  Orest Olejnik ,  Bruce A. Firestone

IPC分类号： A61K38/13 ,  A61K38/12 ,  A61K9/36 ,  A61K31/715

CPC分类号： A61K38/13 ,  A61K9/0048 ,  Y10S514/912 ,  Y10S514/975

摘要： A composition comprising a therapeutically effective amount of cyclosporin A, a blend of oils having a specific gravity of from 0.90 to 1.07, and a surfactant is disclosed herein.

公开(公告)号：US20120270805A1

公开(公告)日：2012-10-25

申请号：US13536479

申请日：2012-06-28

申请人： JAMES N. CHANG ,  Orest Olejnik ,  Bruce A. Firestone

发明人： JAMES N. CHANG ,  Orest Olejnik ,  Bruce A. Firestone

IPC分类号： A61K38/13 ,  A61P27/02

CPC分类号： A61K38/13 ,  A61K9/0048 ,  A61K9/107 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K47/44

摘要： A composition is disclosed herein comprising from about 0.001% to about 0.4% cyclosporin A, castor oil, and a surfactant selected from the group consisting of alcohol ethoxylates, alcohols, alkyl glycosides, alkyl polyglycosides, alkylphenol ethoxylates, amine oxides, block polymers, carboxylated alcohol or alkylphenol ethoxylates, carboxylic acids/fatty acids, cellulose derivatives, ethoxylated alcohols, ethoxylated alkylphenols, ethoxylated aryl phenols, ethoxylated fatty acids, ethoxylated fatty acids, ethoxylated fatty esters and oils, fatty alcohols, fatty esters, glycol esters, lanolin-based derivatives, lecithin and lecithin derivatives, lignin and lignin derivatives, methyl esters, monoglycerides and derivatives, phosphalipids, polyacrylic acids, polyethylene glycols, polyethylene oxide-polypropylene oxide copolymers, polyethylene oxides, polymeric surfactants, polypropylene oxides, propoxylated alcohols, propoxylated alkyl phenols, propoxylated fatty acids, protein-based surfactants, sarcosine derivatives, silicone-based surfactants, sorbitan derivatives, stearates, sucrose and glucose esters and derivatives, and combinations thereof.

摘要翻译： 本文公开了一种组合物，其包含约0.001％至约0.4％的环孢菌素A，蓖麻油和选自醇乙氧基化物，醇，烷基糖苷，烷基多糖苷，烷基酚乙氧基化物，氧化胺，嵌段聚合物，羧化的 醇或烷基酚乙氧基化物，羧酸/脂肪酸，纤维素衍生物，乙氧基化醇，乙氧基化烷基酚，乙氧基化芳基酚，乙氧基化脂肪酸，乙氧基化脂肪酸，乙氧基化脂肪酯和油，脂肪醇，脂肪酯，二醇酯，羊毛脂基 衍生物，卵磷脂和卵磷脂衍生物，木质素和木质素衍生物，甲酯，单酸甘油酯和衍生物，磷脂，聚丙烯酸，聚乙二醇，聚环氧乙烷 - 聚氧丙烯共聚物，聚环氧乙烷，聚合物表面活性剂，聚环氧丙烷，丙氧基化醇，丙氧基化烷基酚， 丙氧基化脂肪酸，基于蛋白质的surfa 硅藻土衍生物，硅氧烷基表面活性剂，脱水山梨糖醇衍生物，硬脂酸盐，蔗糖和葡萄糖酯及其衍生物及其组合。

公开(公告)号：US20120157499A1

公开(公告)日：2012-06-21

申请号：US13407906

申请日：2012-02-29

申请人： Patrick M. Hughes ,  Orest Olejnik

发明人： Patrick M. Hughes ,  Orest Olejnik

IPC分类号： A61K31/4436 ,  A61P37/08 ,  A61P35/00 ,  A61P27/02 ,  A61K31/23

CPC分类号： A61K31/557 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/1647 ,  A61K31/203

摘要： The present invention relates to method of sustained-delivery of an active drug to a posterior part of an eye of a mammal to treat or prevent a disease or condition affecting said mammal, wherein said disease or condition can be treated or prevented by the action of said active drug upon said posterior part of the eye, comprising administering an effective amount of an ester prodrug of the active drug subconjunctivally or periocularly. Preferably, the active drug is more than about 10 times as active as the prodrug. Other aspects of this invention deal with the treatment of certain diseases by the periocular or subconjunctival delivery of an ester prodrug, and certain pharmaceutical products containing ester prodrugs for periocular or subconjunctival administration.

摘要翻译： 本发明涉及将活性药物持续递送至哺乳动物眼睛的后部以治疗或预防影响所述哺乳动物的疾病或病症的方法，其中所述疾病或病症可以通过以下作用来治疗或预防： 所述活性药物在眼睛的所述后部，包括给予有效量的活性药物的结膜下或眼下的酯前药。 优选地，活性药物的活性大于前药的约10倍。 本发明的其它方面涉及通过酯前药的眼周或结膜下递送治疗某些疾病，以及含有用于眼周或结膜下给药的酯前药的某些药物产品。

公开(公告)号：US20100331430A1

公开(公告)日：2010-12-30

申请号：US12824387

申请日：2010-06-28

申请人： Orest Olejnik

发明人： Orest Olejnik

IPC分类号： A61K47/12 ,  A61P27/02

CPC分类号： A61K9/0048 ,  A61K9/08

摘要： The invention provides ophthalmic compositions preserved using propionic preservative components alone or in combination with at least one additional preservative. In particular, an improvement in anti-microbial activity against bacteria is seen in addition to activity specific to fungal organisms and/or mold.

摘要翻译： 本发明提供使用丙酸防腐剂组分单独或与至少一种另外的防腐剂组合保存的眼用组合物。 特别地，除了对真菌生物体和/或霉菌特异性的活性之外，还观察到针对细菌的抗微生物活性的改善。

公开(公告)号：US20100068244A1

公开(公告)日：2010-03-18

申请号：US12577114

申请日：2009-10-09

申请人： Patrick M. Hughes ,  Orest Olejnik

发明人： Patrick M. Hughes ,  Orest Olejnik

IPC分类号： A61K9/00 ,  A61K39/08 ,  A61K39/02 ,  A61P37/04 ,  A61P31/08

CPC分类号： A61K9/0024 ,  A61K9/0051 ,  A61K9/204 ,  A61K38/4893

摘要： Biodegradable neurotoxin implants and methods of making and using such implants are provided. Biodegradable neurotoxin implants include a neurotoxin, a biodegradable polymer component, and an acidity regulating component. The biodegradable polymer component is effective in controlling the release of the neurotoxin from the implant when the implant is located in a patient's body. The acidity regulating component is effective in maintaining a pH of the implant in a desired range that may be effective in stabilizing the neurotoxin as the implant biodegrades when the implant is located in a patient's body. In one embodiment, an implant includes a botulinum toxin, a biodegradable polymer, and either monomers from which a biodegradable polymer is derived or oligomers including monomeric units substantially identical to a monomer from which a biodegradable polymer is derived, or a combination of such monomers and oligomers. The oligomers and biodegradable polymer may be derived from a single type of monomer. The implants disclosed herein may be administered to a human or animal patient in which a therapeutic effect is desired for prolonged periods of time.

摘要翻译： 提供了可生物降解的神经毒素植入物和制造和使用这种植入物的方法。 可生物降解的神经毒素植入物包括神经毒素，可生物降解的聚合物组分和酸度调节组分。 当植入物位于患者体内时，可生物降解的聚合物组分有效地控制来自植入物的神经毒素的释放。 酸性调节组分有效地将植入物的pH保持在期望的范围内，当植入物位于患者体内时，当植入物生物降解时，稳定神经毒素是有效的。 在一个实施方案中，植入物包括肉毒杆菌毒素，可生物降解聚合物，以及衍生生物可降解聚合物的单体或包含单体单元的寡聚物，所述单体基本上与衍生可生物降解聚合物的单体相同，或这些单体和 低聚物。 低聚物和可生物降解的聚合物可以衍生自单一类型的单体。 本文公开的植入物可以施用于需要长时间治疗效果的人或动物患者。

公开(公告)号：US20070015694A1

公开(公告)日：2007-01-18

申请号：US11255821

申请日：2005-10-19

申请人： James Chang ,  Orest Olejnik ,  Bruce Firestone

发明人： James Chang ,  Orest Olejnik ,  Bruce Firestone

IPC分类号： A61K38/13 ,  A61K36/47

CPC分类号： A61K38/13 ,  A61K9/0048 ,  A61K9/1075 ,  A61K36/00 ,  A61K47/44 ,  Y10S514/912 ,  Y10S514/975 ,  A61K2300/00

摘要： A composition is disclosed herein comprising from about 0.001% to about 0.4% cyclosporin A, castor oil, and a surfactant selected from the group consisting of alcohol ethoxylates, alcohols, alkyl glycosides, alkyl polyglycosides, alkylphenol ethoxylates, amine oxides, block polymers, carboxylated alcohol or alkylphenol ethoxylates, carboxylic adds/fatty acids, cellulose derivatives, ethoxylated alcohols, ethoxylated alkylphenols, ethoxylated aryl phenols, ethoxylated fatty acids, ethoxylated fatty acids, ethoxylated fatty esters and oils, fatty alcohols, fatty esters, glycol esters, lanolin-based derivatives, lecithin and lecithin derivatives, lignin and lignin derivatives, methyl esters, monoglycerides and derivatives, phosphalipids, polyacrylic acids, polyethylene glycols, polyethylene oxide-polypropylene oxide copolymers, polyethylene oxides, polymeric surfactants, polypropylene oxides, propoxylated alcohols, propoxylated alkyl phenols, propoxylated fatty acids, protein-based surfactants, sarcosine derivatives, silicone-based surfactants, sorbitan derivatives, stearates, sucrose and glucose esters and derivatives, and combinations thereof.

摘要翻译： 本文公开了一种组合物，其包含约0.001％至约0.4％的环孢菌素A，蓖麻油和选自醇乙氧基化物，醇，烷基糖苷，烷基多糖苷，烷基酚乙氧基化物，氧化胺，嵌段聚合物，羧化的 醇或烷基酚乙氧基化物，羧酸添加物/脂肪酸，纤维素衍生物，乙氧基化醇，乙氧基化烷基酚，乙氧基化芳基酚，乙氧基化脂肪酸，乙氧基化脂肪酸，乙氧基化脂肪酯和油，脂肪醇，脂肪酯，二醇酯，羊毛脂基 衍生物，卵磷脂和卵磷脂衍生物，木质素和木质素衍生物，甲酯，单酸甘油酯和衍生物，磷脂，聚丙烯酸，聚乙二醇，聚环氧乙烷 - 聚氧丙烯共聚物，聚环氧乙烷，聚合物表面活性剂，聚环氧丙烷，丙氧基化醇，丙氧基化烷基酚， 丙氧基化脂肪酸，蛋白质类表面活性剂 鞣剂，肌氨酸衍生物，硅氧烷基表面活性剂，脱水山梨糖醇衍生物，硬脂酸盐，蔗糖和葡萄糖酯及其衍生物及其组合。

公开(公告)号：US20060046958A1

公开(公告)日：2006-03-02

申请号：US10521367

申请日：2004-08-25

申请人： Peter Bakhit ,  Richard Graham ,  Orest Olejnik

发明人： Peter Bakhit ,  Richard Graham ,  Orest Olejnik

IPC分类号： A61K38/17 ,  A61K31/715 ,  A61K31/557

CPC分类号： A61K38/17 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/715 ,  A61K38/1709 ,  A61K2300/00

摘要： Compositions, methods, and pharmaceutical products related to prostaglandin-related compounds and trefoil factor family peptides are disclosed herein. Of particular interest are compositions and methods useful for the treatment of glaucoma with a reduced occurrence of hyperemia.

摘要翻译： 本文公开了与前列腺素相关化合物和三叶因子家族肽相关的组合物，方法和药物产品。 特别感兴趣的是用于治疗青光眼的组合物和方法，其中发生充血发生。

公开(公告)号：US20050277698A1

公开(公告)日：2005-12-15

申请号：US11154024

申请日：2005-06-15

申请人： Patrick Hughes ,  Orest Olejnik

发明人： Patrick Hughes ,  Orest Olejnik

IPC分类号： A61K31/13 ,  A61K9/14

CPC分类号： A61K31/13

摘要： Disclosed herein are aqueous solutions comprising a neuroprotective amine related to adamantane and a polyanionic polymer. Also disclosed herein are methods of treating glaucoma and methods of treating a disease or a condition wherein migration or proliferation of retinal pigment epithelium or glial cells causes or contributes to the cause of said disease or condition.

摘要翻译： 本文公开了包含与金刚烷和聚阴离子聚合物相关的神经保护胺的水溶液。 本文还公开了治疗青光眼的方法和治疗疾病或其中视网膜色素上皮细胞或神经胶质细胞的迁移或增殖导致或有助于所述疾病或病症原因的病症的方法。

公开(公告)号：US20050271705A1

公开(公告)日：2005-12-08

申请号：US11119024

申请日：2005-04-29

申请人： Patrick Hughes ,  Orest Olejnik ,  Glenn Huang ,  Joan-En Chang-Lin ,  Thierry Nivaggioli ,  JaneGuo Shiah ,  Michele Boix ,  Christian Sarrazin

发明人： Patrick Hughes ,  Orest Olejnik ,  Glenn Huang ,  Joan-En Chang-Lin ,  Thierry Nivaggioli ,  JaneGuo Shiah ,  Michele Boix ,  Christian Sarrazin

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K31/07 ,  A61K31/203 ,  A61K31/19 ,  A61K31/20

CPC分类号： A61K31/07 ,  A61K9/0051 ,  A61K9/1647 ,  A61K31/203

摘要： Biocompatible intraocular implants include a retinoid component and a biodegradable polymer that is effective to facilitate release of the retinoid component into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy.

摘要翻译： 生物相容性眼内植入物包括类视黄醇组分和可生物降解的聚合物，其有效促进类视黄醇组分长时间释放到眼睛中。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生，例如视网膜损伤，包括青光眼和增生性玻璃体视网膜病变。

公开(公告)号：US20050244474A1

公开(公告)日：2005-11-03

申请号：US11118288

申请日：2005-04-29

申请人： Glenn Huang ,  Thierry Nivaggioli ,  Lon Spada ,  Hiroshi Sugimoto ,  Wendy Blanda ,  James Chang ,  Orest Olejnik

发明人： Glenn Huang ,  Thierry Nivaggioli ,  Lon Spada ,  Hiroshi Sugimoto ,  Wendy Blanda ,  James Chang ,  Orest Olejnik

IPC分类号： A61K9/00 ,  A61K31/00 ,  A61K31/573 ,  A61K45/06 ,  A61F2/00

CPC分类号： A61K9/0051 ,  A61K9/0092 ,  A61K31/573 ,  A61K31/58 ,  A61K45/06 ,  A61K2300/00

摘要： Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants may be placed in an eye to treat one or more ocular conditions. The steroid is released from the implant for more than about two months, and may be release for more than several years.

摘要翻译： 生物相容性眼内植入物包括彼此相关的类固醇和聚合物，以促进类固醇进入眼睛大于约两个月的时间。 类固醇可以与可生物降解的聚合物基质相关联，例如两种可生物降解聚合物的基质。 或者，类固醇可以与具有一个或多个开口有效以允许类固醇释放到外部环境中的聚合物涂层相关联。 植入物可以放置在眼睛中以治疗一种或多种眼睛状况。 类固醇从植入物中释放超过约两个月，可能会释放超过几年。