公开(公告)号：US5589501A

公开(公告)日：1996-12-31

申请号：US343817

申请日：1994-11-22

申请人： Jesus E. Carrera ,  Almudena R. Esteban ,  Andr e Mann ,  Ang ele Schoenfelder ,  Darryle D. Schoepp ,  Concepcion P. Tercero ,  Camille-Georges Wermuth

发明人： Jesus E. Carrera ,  Almudena R. Esteban ,  Andr e Mann ,  Ang ele Schoenfelder ,  Darryle D. Schoepp ,  Concepcion P. Tercero ,  Camille-Georges Wermuth

IPC分类号： A61K31/00 ,  A61K31/19 ,  A61K31/195 ,  A61K31/20 ,  A61K31/215 ,  A61K31/38 ,  A61K31/41 ,  A61P1/08 ,  A61P9/08 ,  A61P9/10 ,  A61P25/00 ,  A61P25/04 ,  A61P25/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  A61P43/00 ,  C07C229/36 ,  C07D257/04 ,  C07D333/24 ,  C07D409/06

CPC分类号： C07D257/04 ,  C07C229/36

摘要： A pharmaceutical compound of the formula ##STR1## in which m is 0, 1 or 2, n and q are each 0 or 1 to 5, and p is 0 or 1, X is --CO.sub.2 H or tetrazolyl,Y is --CH.dbd.CH--, andZ is(i) phenyl, naphthyl or thienyl, said phenyl, naphthyl and thienyl being optionally substituted,(ii) --CHR.sup.1 R.sup.2 where R.sup.1 and R.sup.2 are each phenyl, naphthyl or thienyl, said phenyl, naphthyl and thienyl being optionally substituted,(iii) .dbd.CR.sup.1 R.sup.2 where R.sup.1 and R.sup.2 are each phenyl, naphthyl or thienyl, said phenyl, naphthyl and thienyl being optionally substituted, or(iv) ##STR2## where r is 0 or 1 to 3 and the phenyl rings are optionally substituted; provided that when Z is phenyl and m is 1, p is 1; and salts and esters thereof.

摘要翻译： 其中m为0,1或2，n和q各自为0或1至5，p为0或1的式（IMAGE）的药物化合物，X为-CO 2 H或四唑基，Y为-CH = CH - ，和Z是（i）苯基，萘基或噻吩基，所述苯基，萘基和噻吩基任选被取代，（ii）-CHR 1 R 2，其中R 1和R 2各自为苯基，萘基或噻吩基，所述苯基，萘基和噻吩基任选被取代 ，（iii）= CR1R2其中R 1和R 2各自为苯基，萘基或噻吩基，所述苯基，萘基和噻吩基任选被取代，或（iv）其中r为0或1至3，并且苯环是任选取代的 ; 条件是当Z为苯基且m为1时，p为1; 及其盐和酯。