公开(公告)号：US20090205426A1

公开(公告)日：2009-08-20

申请号：US11921624

申请日：2006-04-15

Applicant: Klaus Balschat ,  Tobias Fritsche ,  Alfred Gagel ,  Steffen Kirchner ,  Hans-Joachim Muench ,  Olaf Nicholas ,  Jochen Schneider ,  Reiner Spickermann ,  Santer Zur Host-Meyer

Inventor： Klaus Balschat ,  Tobias Fritsche ,  Alfred Gagel ,  Steffen Kirchner ,  Hans-Joachim Muench ,  Olaf Nicholas ,  Jochen Schneider ,  Reiner Spickermann ,  Santer Zur Host-Meyer

IPC: G01N29/032

CPC classification number: G01N29/032 ,  A61M1/3626 ,  G01N2291/02433 ,  G01N2291/02466 ,  G01N2291/02854

Abstract: The present invention relates to a method and a device for monitoring a flowing medium, in particular the blood flowing in an extracorporeal blood circulation, for the presence of air, in particular micro-bubbles. A sequence of signal pulses or a continuous signal is injected into the flowing medium, and the signal pulses or continuous signal leaving the flowing medium are received. To detect micro-bubbles, a signal pattern that is characteristic of the variation over time of the received signal pulses or the continuous signal in a predetermined period of time is extracted from the signal received. The characteristic signal pattern is compared with one or more characteristic reference patterns, and the presence of air bubbles is determined if the characteristic signal pattern deviates from the characteristic reference pattern by a predetermined amount. Statistical characteristic variables, in particular the variance, are preferably determined from the signal patterns and compared with one another.

Abstract translation: 本发明涉及用于监测流动介质，特别是在体外血液循环中流动的血液，用于存在空气，特别是微气泡的方法和装置。 信号脉冲序列或连续信号被注入到流动介质中，并且接收离开流动介质的信号脉冲或连续信号。 为了检测微气泡，从接收到的信号中提取出在接收到的信号脉冲或连续信号随时间变化的特征的信号模式。 将特征信号图案与一个或多个特征参考图案进行比较，并且如果特征信号图案偏离特征参考图案预定量，则确定气泡的存在。 统计特征变量，特别是方差，优选地根据信号图案确定并相互比较。

公开(公告)号：US06804991B2

公开(公告)日：2004-10-19

申请号：US10342851

申请日：2003-01-14

Applicant: Klaus Balschat ,  Helmuth Ender ,  Alfred Gagel ,  Reiner Spickermann

Inventor： Klaus Balschat ,  Helmuth Ender ,  Alfred Gagel ,  Reiner Spickermann

IPC: G01M304

CPC classification number: A61M1/16 ,  A61M1/1601 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/3331 ,  A61M2205/50

Abstract: In order to detect a leakage in a fluid system of a blood treatment apparatus having an extracorporeal blood circuit, the pressure in the fluid system is measured continuously during a predetermined period of the duration of treatment, and the leak rates are calculated from the change in the pressure at predetermined time intervals of the predetermined period of the duration of treatment. The leakage volume in the predetermined period of the duration of treatment is calculated from the leak rates, and the leakage volume is compared with a predetermined limit value. If the leakage volume is greater than the limit value, this indicates a possible loss of leaktightness in the system. This can be verified with a conventional pressure-holding test. The method and device are characterized by the fact that it is not necessary in principle to interrupt the blood treatment in order to detect a loss of leaktightness.

Abstract translation: 为了检测具有体外血液回路的血液处理装置的流体系统的泄漏，在治疗期间的预定期间内连续地测量流体系统中的压力，并且根据变化计算泄漏率 在治疗持续时间的预定时间段的预定时间间隔的压力。 根据泄漏率计算处理持续时间的规定期间的泄漏量，将泄漏量与规定的极限值进行比较。 如果泄漏量大于极限值，则表示系统中可能会有泄漏密封损失。 这可以通过常规的压力保持测试来验证。 该方法和装置的特征在于，原则上不需要中断血液处理以检测泄漏密度的损失。

公开(公告)号：US6066261A

公开(公告)日：2000-05-23

申请号：US219045

申请日：1998-12-23

Applicant: Reiner Spickermann

Inventor： Reiner Spickermann

IPC: A61M1/14 ,  A61M1/16 ,  B01D61/32 ,  B01D61/28 ,  B01D65/10

CPC classification number: A61M1/16 ,  A61M2205/702 ,  A61M2205/705

Abstract: To monitor the functionality of a partial device of a blood treatment machine, an excess pressure is built up on the blood side and on the dialysis fluid side and is monitored to detect a pressure drop. To do so, the flow path through the dialysis fluid inlet line (12), the dialysis fluid outlet line (13) and the blood outlet line (6) can be interrupted, and the blood pump (7) is started. The test pressure on the dialysis fluid side is built up due to the ultrafiltrate passing through the membrane (2) of the dialyzer (1). Any leakage in the closed volume, which includes a part of the blood path as well as part of the dialysis fluid path, is then detected by a (greater) pressure drop.

Abstract translation: 为了监测血液处理机的部分装置的功能，在血液侧和透析液侧形成过量的压力，并进行监测以检测压降。 为此，可以中断穿过透析液入口管线（12），透析液出口管线（13）和血液出口管线（6）的流动路径，并启动血液泵（7）。 由于超滤液通过透析器（1）的膜（2），渗透液侧的测试压力被建立起来。 然后通过（更大的）压降检测封闭体积中包括血液路径的一部分以及部分透析流体路径的任何泄漏。