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21.发明申请公开(公告)号：US20120035137A1
公开(公告)日：2012-02-09
申请号：US13168728
申请日：2011-06-24
IPC分类号： A61K31/6615 , A61P35/02 , A61P35/04
CPC分类号： A61K31/66 , C07F9/65746
摘要： Inositol-tripyrophosphate is an allosteric effector of hemoglobin due to its ability to cross the plasma membrane of red blood cells and deliver oxygen to solid tumors, by lowering the oxygen affinity of the hemoglobin of red blood cells. The present invention is directed to the use of inositol-tripyrophosphate to reduce hemoglobin's affinity for oxygen in circulating red blood cells. The present invention is further directed to the use of inositol-tripyrophosphate to inhibit angiogenesis and enhance radiation sensitivity of hypoxic tumors. The present invention is further directed to the use of inositol-tripyrophosphate for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.
摘要翻译： 肌醇三磷酸盐是血红蛋白的变构效应物，因为它能够通过降低红细胞血红蛋白的氧亲合力而穿过红细胞的质膜并将氧传递给实体瘤。 本发明涉及肌醇三磷酸降低血红蛋白在循环红细胞中对氧的亲和力的用途。 本发明还涉及肌醇三磷酸盐抑制血管发生和增强缺氧性肿瘤的放射敏感性的用途。 本发明还涉及肌醇三磷酸盐用于治疗各种类型的癌症，阿尔茨海默氏病，中风和骨质疏松症的用途。
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公开(公告)号：US20090238840A1
公开(公告)日：2009-09-24
申请号：US12386140
申请日：2009-04-14
申请人： Andrea Pfeifer , Claude Nicolau
发明人： Andrea Pfeifer , Claude Nicolau
CPC分类号： A61K39/0008 , C07K16/18 , Y10S424/812
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis.In particular, the present invention provides novel methods and compositions for eliciting a highly specific and highly effective immune response in an organism, but particularly within an animal, particularly a mammal or a human, which is capable of preventing or alleviating amyloidosis, or the symptoms associated with amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD), including diseases or conditions characterized by a loss of cognitive memory capacity such as, for example, mild cognitive impairment (MCI).
摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样样蛋白（包括淀粉样变性）引起或与之相关的疾病和病症。 特别地，本发明提供了新颖的方法和组合物，用于在生物体内，特别是能够预防或缓解淀粉样变性的动物，特别是哺乳动物或人类中引发高度特异性和高度有效的免疫应答，或症状 与淀粉样变性有关的一组疾病和病症，包括继发淀粉样变性和年龄相关性淀粉样变性，包括但不限于神经系统疾病如阿尔茨海默氏病（AD），包括特征在于认知丧失的疾病或病症 记忆能力，例如轻度认知障碍（MCI）。
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公开(公告)号：US20080312138A1
公开(公告)日：2008-12-18
申请号：US12150946
申请日：2008-05-01
申请人： Claude Nicolau , Jean-Marie Lehn , Ruth Greferath
发明人： Claude Nicolau , Jean-Marie Lehn , Ruth Greferath
IPC分类号： A61K38/22 , A61K31/7042 , A61P7/06 , A61P7/00
CPC分类号： A61K31/66 , A61K31/6615 , A61K35/15 , A61K38/1816 , A61K2300/00
摘要： The present invention provides methods and compositions to replace up to 90% of erythropoietin use in the treatment of anemias and hypoxias. The method employs acid and salt forms of inositol-tripyrophosphate (ITPP) isomers to shift the P50 value of hemoglobin, thereby improving the rate and efficiency of oxygenation by blood even when red blood cell counts are low. Indications for the new method include anemias and hypoxia arising from infection, chemotherapy, premature birth, altitude change, compromised lung or heart function, aplastic anemia and anemia associated with a myelodysplastic syndrome, and other causes.
摘要翻译： 本发明提供了用于替代高达90％的红细胞生成素用于治疗贫血和缺氧的方法和组合物。 该方法采用酸性和盐形式的肌醇三磷酸（ITPP）异构体来移动血红蛋白的P50值，从而即使红细胞计数低，也能提高血液氧合的速率和效率。 新方法的适应症包括感染，化疗，早产，高原变化，肺或心脏功能受损，再生障碍性贫血和与骨髓增生异常综合征相关的贫血引起的贫血和缺氧以及其他原因。
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公开(公告)号：US20080200437A1
公开(公告)日：2008-08-21
申请号：US11967424
申请日：2007-12-31
申请人： Jean-Marie Lehn , Srinivasu Pothukanuri , Alexandros Koumbis , Carolina Duarte , Claude Nicolau
发明人： Jean-Marie Lehn , Srinivasu Pothukanuri , Alexandros Koumbis , Carolina Duarte , Claude Nicolau
IPC分类号： A61K31/6615 , C07F9/145 , A61P35/00 , A61P7/00
CPC分类号： C07F9/144 , C07F9/093 , C07F9/6561 , C07F9/65744 , C07F9/65746
摘要： The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inositols. The invention also relates to compositions of the polyphosphorylated and pyrophosphate derivatives of inositol and other similar, more lipophilic derivatives, and their use as allosteric effectors, cell-signaling molecule analogs, and therapeutic agents.
摘要翻译： 本发明涉及环磷酸的多磷酸化和焦磷酸衍生物。 更具体地说，本发明涉及肌醇的多磷酸化和焦磷酸衍生物。 本发明还涉及肌醇和其它类似的，更亲脂的衍生物的多磷酸化和焦磷酸衍生物的组合物，以及它们作为变构效应器，细胞信号分子类似物和治疗剂的用途。
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公开(公告)号：US20060258626A1
公开(公告)日：2006-11-16
申请号：US11396338
申请日：2006-03-31
CPC分类号： A61K31/66 , C07F9/65746
摘要： Inositol-tripyrophosphate is an allosteric effector of hemoglobin due to its ability to cross the plasma membrane of red blood cells and deliver oxygen to solid tumors, by lowering the oxygen affinity of the hemoglobin of red blood cells. The present invention is directed to the use of inositol-tripyrophosphate to reduce hemoglobin's affinity for oxygen in circulating red blood cells. The present invention is further directed to the use of inositol-tripyrophosphate to inhibit angiogenesis and enhance radiation sensitivity of hypoxic tumors. The present invention is further directed to the use of inositol-tripyrophosphate for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.
摘要翻译： 肌醇三磷酸盐是血红蛋白的变构效应物，因为它能够通过降低红细胞血红蛋白的氧亲合力而穿过红细胞的质膜并将氧传递给实体瘤。 本发明涉及肌醇三磷酸降低血红蛋白在循环红细胞中对氧的亲和力的用途。 本发明还涉及肌醇三磷酸盐抑制血管发生和增强缺氧性肿瘤的放射敏感性的用途。 本发明还涉及肌醇三磷酸盐用于治疗各种类型的癌症，阿尔茨海默氏病，中风和骨质疏松症的用途。
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