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公开(公告)号:US08075889B2
公开(公告)日:2011-12-13
申请号:US11608408
申请日:2006-12-08
申请人: Richard Evan Gelinas , Mitra Choudhury Singhal , Yi Zhang , Andrew George Popplewell , Ralph Adams
发明人: Richard Evan Gelinas , Mitra Choudhury Singhal , Yi Zhang , Andrew George Popplewell , Ralph Adams
IPC分类号: A61K39/00 , A61K39/395
CPC分类号: A61K39/3955 , A61K2039/505 , C07K16/248 , C07K2316/96 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/11
摘要: The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
摘要翻译: 本发明涉及对IL-6的抗原决定簇具有特异性的抗体分子,抗体分子的治疗用途以及产生所述抗体分子的方法。
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公开(公告)号:US20070154481A1
公开(公告)日:2007-07-05
申请号:US11608408
申请日:2006-12-08
申请人: Richard Gelinas , Mitra Singhal , Yi Zhang , Andrew Popplewell , Ralph Adams
发明人: Richard Gelinas , Mitra Singhal , Yi Zhang , Andrew Popplewell , Ralph Adams
IPC分类号: A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/24
CPC分类号: A61K39/3955 , A61K2039/505 , C07K16/248 , C07K2316/96 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/11
摘要: The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
摘要翻译: 本发明涉及对IL-6的抗原决定簇具有特异性的抗体分子,抗体分子的治疗用途以及产生所述抗体分子的方法。
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公开(公告)号:US10562966B2
公开(公告)日:2020-02-18
申请号:US13817961
申请日:2011-08-19
摘要: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.
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公开(公告)号:US20120129219A1
公开(公告)日:2012-05-24
申请号:US13242429
申请日:2011-09-23
CPC分类号: C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: The invention relates to antibody molecules having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecules and methods of producing the antibody molecules.
摘要翻译: 本发明涉及对IL-17的抗原决定簇具有特异性的抗体分子,抗体分子的治疗用途和产生抗体分子的方法。
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25.
公开(公告)号:US20120034656A1
公开(公告)日:2012-02-09
申请号:US13218857
申请日:2011-08-26
CPC分类号: C07K16/244 , A61K47/48215 , A61K47/60 , A61K2039/505 , C07K16/464 , C07K2317/20 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: The invention relates to an antibody molecule having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecule and methods for producing said antibody molecule.
摘要翻译: 本发明涉及对IL-17的抗原决定簇具有特异性的抗体分子,抗体分子的治疗用途以及产生所述抗体分子的方法。
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26.
公开(公告)号:US20090117126A1
公开(公告)日:2009-05-07
申请号:US11791109
申请日:2005-11-16
IPC分类号: C07K16/28 , A61K39/395 , C12N5/06
CPC分类号: C07K16/244 , A61K47/48215 , A61K47/60 , A61K2039/505 , C07K16/464 , C07K2317/20 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: The invention relates to an antibody molecule having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecule and methods for producing said antibody molecule.
摘要翻译: 本发明涉及对IL-17的抗原决定簇具有特异性的抗体分子,抗体分子的治疗用途以及产生所述抗体分子的方法。
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