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公开(公告)号：US06682167B2
公开(公告)日：2004-01-27
申请号：US10183846
申请日：2002-06-27
IPC分类号： B41J2165
CPC分类号： B41J2/16547
摘要： A method for reducing a servicing noise is provided. In a measuring action, a servicing position is measured using a full pushing force of an actuator applied to a service station. In a disengaging action, the actuator is disengaged from the service station. In a reducing action, the pushing force is reduced to a minimum value. In an engaging action, the service station is engaged with the actuator. In a monitoring action, a position of the actuator is monitored during the engagement. In a comparing action, the actuator position is compared to the stored servicing position. In an increasing action, the pushing force is increased for future engagements if the servicing position has not been reached. A printing mechanism configured to employ such a method is also provided.
摘要翻译： 提供了一种降低维修噪音的方法。 在测量动作中，使用施加到维修站的致动器的全推力来测量维修位置。 在脱离动作中，致动器从维修站脱离。 在还原作用下，推力减小到最小值。 在接合动作中，维修站与致动器接合。 在监视动作中，在接合期间监视致动器的位置。 在比较动作中，将致动器位置与存储的维修位置进行比较。 在增加的作用下，如果还没有达到维修位置，推动力将增加以备将来的作业。 还提供了构造成采用这种方法的打印机构。
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公开(公告)号：USD376806S
公开(公告)日：1996-12-24
申请号：US26145
申请日：1994-07-20
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公开(公告)号：US5218122A
公开(公告)日：1993-06-08
申请号：US555804
申请日：1990-07-18
申请人： Gerald I. Goe , Robert D. Davis
发明人： Gerald I. Goe , Robert D. Davis
IPC分类号： C07D213/08 , C07D213/09 , C07D213/10
CPC分类号： C07D213/08 , C07D213/10
摘要： An improved base synthesis process and catalyst for the preparation of pyridine or its alkylpyridine derivatives involving the catalytic reaction of one or more aldehydes and/or ketones containing from one to about five carbon atoms, with at least one reactant having more than one carbon atom, with ammonia in the gas phase. The improved catalyst comprises an effective amount of a shape-selective zeolite which has been modified by treatment with one or more metal ions or compounds of tungsten. zinc or tin. The preferred zeolite has a constraint index of about 1 to 12 and a high silica content and correspondingly low concentration of ion-exchange sites with minimal to no acidic sites present.
摘要翻译： 一种用于制备吡啶或其烷基吡啶衍生物的改进的碱合成方法和催化剂，涉及一种或多种含有1至约5个碳原子的醛和/或酮与至少一种具有多于一个碳原子的反应物的催化反应， 与氨在气相。 改进的催化剂包含有效量的形状选择沸石，其通过用一种或多种金属离子或钨化合物处理而被改性。 锌或锡。 优选的沸石具有约1至12的约束指数和高二氧化硅含量，并且相应地具有极少至无酸性位点的离子交换位点的低浓度。
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公开(公告)号：US07985420B2
公开(公告)日：2011-07-26
申请号：US10406574
申请日：2003-04-04
IPC分类号： A61K9/22
CPC分类号： A61K9/2027 , A61K9/2054 , A61K9/209 , A61K9/5084 , A61K31/09 , A61K31/137 , A61K31/485 , A61K31/495 , A61K2300/00
摘要： The invention relates to a novel pharmaceutical sustained release formulation of guaifenesin and pseudoephedrine. The formulation may comprise a hydrophilic polymer, preferably a hydroxypropyl methylcellulose, and a water-insoluble polymer, preferably an acrylic resin, in a ratio range of about one-to-one (1:1) to about nine-to-one (9:1), more preferably a range of about three-to-two (3:2) to about six-to-one (6:1), and most preferably in a range of about two-to-one (2:1) to about four-to-one (4:1) by weight. This formulation capable of providing therapeutically effective bioavailability of guaifenesin for at least twelve hours after dosing in a human subject. The invention also relates to a modified release product which has two portions: a first portion having an immediate release formulation of guaifenesin and a second portion having a sustained release formulation of guaifenesin, wherein one or both portions further comprises pseudoephedrine. The modified release product has a maximum guaifenesin serum concentration equivalent to that of an immediate release guaifenesin tablet, and is capable of providing therapeutically effective bioavailability of guaifenesin for at least twelve hours after dosing in a human subject.
摘要翻译： 本发明涉及愈创甘油醚和伪麻黄碱的新型药物缓释制剂。 制剂可包含亲水性聚合物，优选羟丙基甲基纤维素和水不溶性聚合物，优选丙烯酸树脂，其比例范围为约一对一（1：1）至约九对一（9 ：1），更优选约三至二（3:2）至约六对一（6:1）的范围，最优选在约二至一（2:1）的范围内 ）至约四对一（4:1）重量比。 该制剂能够在给予人受试者后至少十二个小时提供愈创甘油的治疗有效的生物利用度。 本发明还涉及一种具有两部分的改性释放产物：第一部分具有愈创甘油醚的立即释放制剂，第二部分具有愈创甘油醚的缓释制剂，其中一个或两个部分还包含伪麻黄碱。 改性释放产物具有与立即释放愈创甘油醚片剂相当的最大愈创甘油醚血清浓度，并且能够在给予人受试者后至少十二个小时提供愈创甘油的治疗有效的生物利用度。
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公开(公告)号：US20110052689A1
公开(公告)日：2011-03-03
申请号：US12940781
申请日：2010-11-05
CPC分类号： A61K9/2086 , A61K9/2027 , A61K9/2054 , A61K9/209 , A61K9/5084 , A61K31/09 , A61K31/137 , A61K31/485 , A61K31/495 , A61K2300/00
摘要： The invention relates to a novel pharmaceutical sustained release formulation of guaifenesin. The formulation may comprise a hydrophilic polymer, preferably a hydroxypropyl methylcellulose, and a water-insoluble polymer, preferably an acrylic resin, in a ratio range of about one-to-one (1: 1) to about nine-to-one (9: 1), more preferably a range of about three-to-two (3:2) to about six-to-one (6: 1), and most preferably in a range of about two-to-one (2: 1) to about four-to-one (4: 1) by weight. This formulation capable of providing therapeutically effective bioavailability of guaifenesin for at least twelve hours after dosing in a human subject. The invention also relates to a modified release product which has two portions: a first portion having an immediate release formulation of guaifenesin and a second portion having a sustained release formulation of guaifenesin. The modified release product has a maximum guaifenesin serum concentration equivalent to that of an immediate release guaifenesin tablet, and is capable of providing therapeutically effective bioavailability of guaifenesin for at least twelve hours after dosing in a human subject.
摘要翻译： 本发明涉及愈创甘油醚的新型药物缓释制剂。 制剂可包含亲水性聚合物，优选羟丙基甲基纤维素和水不溶性聚合物，优选丙烯酸树脂，其比例范围为约一对一（1：1）至约九对一（9 ：1），更优选约三至二（3:2）至约六对一（6:1）的范围，最优选在约二至一（2:1）的范围内 ）至约四对一（4:1）重量比。 该制剂能够在给予人受试者后至少十二个小时提供愈创甘油的治疗有效的生物利用度。 本发明还涉及一种具有两部分的改良释放产物：第一部分具有愈创甘油醚的立即释放制剂，第二部分具有愈创甘油醚的缓释制剂。 改性释放产物具有与立即释放愈创甘油醚片剂相当的最大愈创甘油醚血清浓度，并且能够在给予人受试者后至少十二个小时提供愈创甘油的治疗有效的生物利用度。
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公开(公告)号：US06372252B1
公开(公告)日：2002-04-16
申请号：US09559542
申请日：2000-04-28
IPC分类号： A61K920
CPC分类号： A61K9/5084 , A61K9/2027 , A61K9/2054 , A61K9/209 , A61K31/09 , A61K31/137 , A61K31/485 , A61K31/495 , A61K2300/00
摘要： The invention relates to a novel pharmaceutical sustained release formulation of guaifenesin. The formulation may comprise a hydrophilic polymer, preferably a hydroxypropyl methylcellulose, and a water-insoluble polymer, preferably an acrylic resin, in a ratio range of about one-to-one (1:1) to about six-to-one (6:1), more preferably a range of about three-to-two (3:2) to about four-to-one (4:1), and most preferably about two-to-one (2:1), by weight. This formulation capable of providing therapeutically effective bioavailability of guaifenesin for at least twelve hours after dosing in a human subject. The invention also relates to a modified release guaifenesin tablet which has two portion: the first portion comprises an immediate release formulation of guaifenesin and the second portion comprises a sustained release formulation of guaifenesin as described above. This two portion, or bi-layer, tablet has a maximum serum concentration equivalent to that of an immediate release guaifenesin tablet, and is capable of providing therapeutically effective bioavailability of guaifenesin for at least twelve hours after dosing in a human subject.
摘要翻译： 本发明涉及愈创甘油醚的新型药物缓释制剂。 制剂可以包含亲水性聚合物，优选羟丙基甲基纤维素和水不溶性聚合物，优选丙烯酸树脂，其比例范围为约一对一（1：1）至约六比一（6 ：1），更优选约三至二（3:2）至约四对一（4:1），最优选约二比一（2:1）的范围 。 该制剂能够在给予人受试者后至少十二个小时提供愈创甘油的治疗有效的生物利用度。 本发明还涉及一种具有两部分的改性释放愈创甘油醚片剂：第一部分包含愈创甘油醚的立即释放制剂，第二部分包含如上所述的愈创甘油醚缓释制剂。 这两部分或双层片剂具有与立即释放愈创甘油醚片剂相当的最大血清浓度，并且能够在给予人受试者后至少十二个小时提供愈创甘油醚治疗有效的生物利用度。
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公开(公告)号：USD299569S
公开(公告)日：1989-01-24
申请号：US754080
申请日：1985-07-12
申请人： Robert D. Davis , Lois S. Davis
设计人： Robert D. Davis , Lois S. Davis
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公开(公告)号：US4196851A
公开(公告)日：1980-04-08
申请号：US943764
申请日：1978-09-20
申请人： Robert D. Davis
发明人： Robert D. Davis
CPC分类号： A61Q13/00 , A61K8/02 , A61K8/0216 , A61L9/046 , Y10S261/89
摘要： A porous sachet tablet prepared by compression molding or tableting a powder composed of insoluble tri-basic calcium phosphate mixed with a minor amount of soluble sodium hexametaphosphate and bonded with a small amount of food starch and internally lubricated with a fatty acid soap, preferably magnesium stearate, to aid tableting. This tablet or blank is preferably prepared by slurrying the phosphates and the binder in water, spray drying the slurry, dry-mixing in the lubricant and compression molding. The tablet is then wetted with a perfume of the desired fragrance to give the sachet tablet.
摘要翻译： 通过压缩或压片由不溶性三碱式磷酸钙组成的粉末与少量可溶性六偏磷酸钠混合并与少量食品淀粉结合并用脂肪酸皂，优选硬脂酸镁进行内部润滑的多孔小袋片剂 ，以帮助压片。 该片剂或坯料优选通过将磷酸盐和粘合剂在水中制浆，喷雾干燥浆料，在润滑剂中进行干混和压塑而制备。 然后用所需香料的香料润湿片剂，得到香囊片剂。
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29.发明授权Method and apparatus for programming and reducing runout in rotating shaft vibration signal detection 失效用于编程和减少旋转轴振动信号检测中的跳动的方法和装置
公开(公告)号：US4135244A
公开(公告)日：1979-01-16
申请号：US817363
申请日：1977-07-20
申请人： Robert D. Davis
发明人： Robert D. Davis
摘要： Method and circuit for detecting the slow roll electrical runout signal of a rotating shaft, as synchronized with a tachometer signal, and impressing this signal waveform in digital form in a memory in an encoding section, and subsequently transferring the digital runout information to a programmed read only memory module, and then using the PROM module in a method and circuit for subtracting electrical runout signals from the composite electrical runout signal and vibration signal generated in a proximity probe circuit by the shaft rotating at operational speed, and monitoring and controlling the encode section to provide low frequency detection lock out circuits and to provide digital readout of the instantaneous mils peak of the composite signal outputs of the subtract runout signal, composite signal and corrected signal.
摘要翻译： 用于检测与转速计信号同步的旋转轴的慢速滚动跳动信号的方法和电路，并将数字形式的该信号波形压印在编码部分的存储器中，随后将数字跳动信息传送到编程读取 然后在方法和电路中使用PROM模块，用于从由复合电气跳动信号减去电气跳动信号和由操作速度旋转的轴在邻近探测电路中产生的振动信号，以及监视和控制编码部分 提供低频检测锁定电路，并提供减法跳动信号，复合信号和校正信号的复合信号输出的瞬时密耳峰值的数字读出。
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30.发明授权Method and circuit for providing electrical runout reduction in rotating shaft vibration detection systems 失效用于在旋转轴振动检测系统中提供电气减速的方法和电路
公开(公告)号：US4134303A
公开(公告)日：1979-01-16
申请号：US817340
申请日：1977-07-20
申请人： Robert D. Davis
发明人： Robert D. Davis
摘要： A method and circuit for reducing by electrical runout subtraction, the runout signal portion of a composite runout signal and vibration signal, which runout subtraction signal is provided by a pre-programmed digital memory circuit module, PROM, that is selectively inserted into the circuit for a given rotating shaft. The PROM is accessed by a phase lock loop, master dynamic clock, synchronized to the tachometer signal, which provides the subtract signal in digital form that is changed to an analog signal and then fed with the composite signal to a differential amplifier circuit that subtracts the PROM waveform from the composite signal. In one mode the subtract amplifier circuit is inhibited in operation when the tachometer signal falls below a given CPM, or when the tachometer signal is lost.
摘要翻译： 一种用于通过电跳差减法，复合跳动信号和振动信号的跳动信号部分减少的方法和电路，该跳动减法信号由预编程的数字存储器电路模块PROM提供，PROM被选择性地插入到电路 给定的旋转轴。 PROM通过锁相回路访问，主动态时钟与转速计信号同步，该信号提供数字形式的减法信号，转换为模拟信号，然后将复合信号馈送到差分放大电路，减法器 PROM波形从复合信号。 在一种模式中，当转速计信号低于给定的CPM时，或当转速计信号丢失时，减法放大器电路在运行中被禁止。
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