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公开(公告)号：US09603802B2
公开(公告)日：2017-03-28
申请号：US12241650
申请日：2008-09-30
申请人： Geoffrey Gerard Hayes , Vincenzo Martinelli , Hassan Mohammad , Derek Allan Prater , Harjit Tamber , Malcolm Walden , Steve Whitelock
发明人： Geoffrey Gerard Hayes , Vincenzo Martinelli , Hassan Mohammad , Derek Allan Prater , Harjit Tamber , Malcolm Walden , Steve Whitelock
IPC分类号： A61K9/16
CPC分类号： A61K9/1635 , A61K9/16 , A61K9/1694 , Y10T428/2982
摘要： The invention relates to a process for preparing a controlled release pharmaceutical extrudate using a melt extruder, wherein the melt extruder comprises a die-head supporting a die-plate in which orifices are located, and a cutter adjacent to the die-head, and wherein the cutter cuts the extruded mix as it emerges under pressure and still molten or softened from the orifices of the die-plate.
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公开(公告)号：US20090029170A1
公开(公告)日：2009-01-29
申请号：US12241650
申请日：2008-09-30
申请人： Geoffrey Gerard Hayes , Vincenzo Martinelli , Hassan Mohammad , Derek Allan Prater , Harjit Tamber , Malcolm Walden , Steve Whitelock
发明人： Geoffrey Gerard Hayes , Vincenzo Martinelli , Hassan Mohammad , Derek Allan Prater , Harjit Tamber , Malcolm Walden , Steve Whitelock
CPC分类号： A61K9/1635 , A61K9/16 , A61K9/1694 , Y10T428/2982
摘要： The invention relates to a process for preparing a controlled release pharmaceutical extrudate using a melt extruder,wherein the melt extruder comprises a die-head supporting a die-plate in which orifices are located, and a cutter adjacent to the die-head, and wherein the cutter cuts the extruded mix as it emerges under pressure and still molten or softened from the orifices of the die-plate.
摘要翻译： 本发明涉及一种使用熔体挤出机制备控释药物挤出物的方法，其中熔融挤出机包括支撑孔的模头和与模头相邻的切割器，其中 挤出的混合物在压力下出现时会切割挤出的混合物，并仍然从模板的孔口熔化或软化。
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公开(公告)号：US10231936B2
公开(公告)日：2019-03-19
申请号：US11603766
申请日：2006-11-22
摘要： Delivery of a drug is controlled to impart a delay before release after administration by formulating the drug with a disruption agent to provide a core, and coating the core with a regulatory membrane comprising a water-soluble gel-forming polymer and a water-insoluble film-forming polymer.
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公开(公告)号：US20130245054A1
公开(公告)日：2013-09-19
申请号：US13816685
申请日：2011-08-11
申请人： Derek Allan Prater , Christof Spitzley , Gerhard Heun , Alexander Schütz , Udo Hahn , Christian Leuner
发明人： Derek Allan Prater , Christof Spitzley , Gerhard Heun , Alexander Schütz , Udo Hahn , Christian Leuner
IPC分类号： A61K31/485
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K2300/00
摘要： The present invention relates to storage stable prolonged release pharmaceutical dosage forms comprising oxycodone or a pharmaceutically acceptable salt thereof and naloxone or a pharmaceutically acceptable salt thereof, the manufacture thereof as well as their use for administration to human beings.
摘要翻译： 本发明涉及包含羟考酮或其药学上可接受的盐和纳络酮或其药学上可接受的盐的储存稳定的延长释放药物剂型，其制备方法及其用于给予人类的用途。
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公开(公告)号：US07704948B2
公开(公告)日：2010-04-27
申请号：US10479069
申请日：2002-05-30
IPC分类号： A61K31/13 , A61K31/132 , A61K31/436 , C12Q1/48
CPC分类号： A61K31/4402 , A61K9/0095 , A61K9/1635 , A61K9/2018 , A61K9/2054 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K31/77 , A61K2300/00
摘要： A stool softener and enteric coated bisacodyl form of a pharmaceutical composition.
摘要翻译： 粪便软化剂和药物组合物的肠溶包衣的比索酸（bisacodyl）形式。
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