公开(公告)号：US20240368213A1

公开(公告)日：2024-11-07

申请号：US18741425

申请日：2024-06-12

Applicant: Sage Therapeutics, Inc.

Inventor： Gabriel Martinez Botella ,  Francesco G. Salituro ,  Albert Jean Robichaud ,  Boyd L. Harrison

IPC: C07J43/00 ,  A61K31/575 ,  A61K31/58 ,  A61K45/06 ,  C07J1/00 ,  C07J3/00 ,  C07J5/00 ,  C07J7/00 ,  C07J9/00 ,  C07J11/00 ,  C07J13/00 ,  C07J21/00 ,  C07J31/00 ,  C07J41/00 ,  C07J51/00 ,  C07J71/00

Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein (II), A, R1, R2, R3a, R4a, R4b, R5, R7a, and R7b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

公开(公告)号：US12129276B2

公开(公告)日：2024-10-29

申请号：US18116557

申请日：2023-03-02

Applicant: SAGE THERAPEUTICS, INC.

Inventor： Boyd L. Harrison ,  Gabriel Martinez Botella ,  Albert Jean Robichaud ,  Francesco G. Salituro

IPC: C07J9/00 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48 ,  A61K31/575 ,  C07J13/00 ,  C07J31/00

CPC classification number: C07J9/00 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/2063 ,  A61K9/4866 ,  A61K31/575 ,  C07J9/005 ,  C07J13/005 ,  C07J13/007 ,  C07J31/006

Abstract: Compounds are provided according to Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein X, Y, R1, R2a, R2b, R4a, R4b, R5a, R5b, R6a, R6b, R7, and R8 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

公开(公告)号：US20240300995A1

公开(公告)日：2024-09-12

申请号：US18430056

申请日：2024-02-01

Applicant: Sage Therapeutics, Inc.

Inventor： Francesco G. Salituro ,  Albert Jean Robichaud ,  Gabriel Martinez Botella ,  Andrew Griffin ,  Boyd L. Harrison ,  Daniel La

IPC: C07J31/00 ,  C07J9/00

CPC classification number: C07J31/006 ,  C07J9/005

Abstract: Compounds are provided according to Formula (A):




and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1A, R1B, n, R2A, R2B, R3, and R4 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

公开(公告)号：US20240287125A1

公开(公告)日：2024-08-29

申请号：US18405657

申请日：2024-01-05

Applicant: Sage Therapeutics, Inc.

Inventor： Gabriel Martinez Botella ,  Boyd L. Harrison ,  Albert Jean Robichaud ,  Francesco G. Salituro

IPC: C07J9/00 ,  C07J13/00 ,  C07J21/00 ,  C07J41/00

CPC classification number: C07J9/00 ,  C07J9/005 ,  C07J13/005 ,  C07J13/007 ,  C07J21/008 ,  C07J41/0061

Abstract: 3beta, 17beta disubstituted steroidal compounds, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, are provided for the prevention and treatment of a variety of CNS-related conditions.

公开(公告)号：US12071453B2

公开(公告)日：2024-08-27

申请号：US17952694

申请日：2022-09-26

Applicant: Sage Therapeutics, Inc.

Inventor： Gabriel Martinez Botella ,  Boyd L. Harrison ,  Albert Jean Robichaud ,  Francesco G. Salituro ,  Robert Jason Herr ,  Robert Borbo Kargbo

IPC: C07J43/00 ,  A61K31/58 ,  A61K45/06 ,  C07J7/00 ,  C07J1/00 ,  C07J13/00 ,  C07J21/00

CPC classification number: C07J43/003 ,  A61K31/58 ,  A61K45/06 ,  C07J1/0059 ,  C07J7/002 ,  C07J7/007 ,  C07J7/0085 ,  C07J13/007 ,  C07J21/00 ,  C07J21/008 ,  A61K31/58 ,  A61K2300/00

Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -------, R1, R2, R3, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

公开(公告)号：US11926646B2

公开(公告)日：2024-03-12

申请号：US17476153

申请日：2021-09-15

Applicant: Sage Therapeutics, Inc.

Inventor： Francesco G. Salituro ,  Albert Jean Robichaud ,  Gabriel Martinez Botella ,  Andrew Griffin ,  Boyd L. Harrison ,  Daniel La

IPC: C07J31/00 ,  C07J9/00

CPC classification number: C07J31/006 ,  C07J9/005

Abstract: Compounds are provided according to Formula (A):




and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1A, R1B, n, R2A, R2B, R3, and R4 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

公开(公告)号：US11851457B2

公开(公告)日：2023-12-26

申请号：US17395155

申请日：2021-08-05

Applicant: Sage Therapeutics, Inc.

Inventor： Francesco G. Salituro ,  Albert Jean Robichaud ,  Gabriel Martinez Botella ,  Boyd L. Harrison ,  Andrew Griffin

IPC: C07J9/00 ,  C07J17/00 ,  A61P25/20 ,  A61P25/28 ,  A61P25/22 ,  A61P19/02 ,  A61P25/18 ,  A61P1/00 ,  A61P25/16 ,  A61P35/00 ,  C07J43/00

CPC classification number: C07J9/00 ,  A61P1/00 ,  A61P19/02 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P35/00 ,  C07J17/00 ,  C07J43/003

Abstract: Compounds are provided according to Formula (I):




and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R2, R3, R4, R5, and R6 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

公开(公告)号：US20230391816A1

公开(公告)日：2023-12-07

申请号：US18455007

申请日：2023-08-24

Applicant: Sage Therapeutics, Inc.

Inventor： Boyd L. Harrison ,  Gabriel Martinez Botella ,  Albert Jean Robichaud ,  Francesco G. Salituro

IPC: C07J41/00 ,  C07J5/00 ,  C07J7/00 ,  C07J17/00

CPC classification number: C07J41/005 ,  C07J5/0015 ,  C07J1/0011 ,  C07J17/00 ,  C07J7/009 ,  C07J7/002

Abstract: Described herein are steroids of Formula (I):




and pharmaceutically acceptable salts thereof, wherein R1, R2a, R2b, R3, R4, R5a, R5b, R6, and Z are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.

公开(公告)号：US20230331768A1

公开(公告)日：2023-10-19

申请号：US18106073

申请日：2023-02-06

Applicant: Sage Therapeutics, Inc.

Inventor： Francesco G. Salituro ,  Albert Jean Robichaud ,  Gabriel Martinez Botella ,  Boyd L. Harrison ,  Andrew Griffin

IPC: C07J43/00 ,  C07J9/00 ,  C07J17/00

CPC classification number: C07J43/003 ,  C07J9/00 ,  C07J9/005 ,  C07J17/00

Abstract: Compounds are provided according to Formula (A): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3′ R4, R5, R6, and RG are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

公开(公告)号：US20230021308A9

公开(公告)日：2023-01-19

申请号：US17242913

申请日：2021-04-28

Applicant: Sage Therapeutics, Inc.

Inventor： Albert Jean Robichaud ,  Gabriel Martinez Botella ,  Boyd L. Harrison ,  Francesco G. Salituro ,  Andrew Griffin ,  Maria Jesus Blanco-Pillado

IPC: C07J43/00 ,  C07J1/00 ,  C07J7/00 ,  C07J41/00 ,  A61P25/00

Abstract: Described herein are neuroactive steroids of Formula (I), Formula (V), or Formula (IX) or a pharmaceutically acceptable salt thereof; wherein each instance of R2, R3, R4, R5, R6, R7, R11a, R11b, R12, R16, R17, R19, and are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a compound described herein and methods of use and treatment, e.g., such as for inducing sedation and/or anesthesia.