公开(公告)号：US20170209251A1

公开(公告)日：2017-07-27

申请号：US15384435

申请日：2016-12-20

Applicant: Sofradim Production

Inventor： Sebastien Francois ,  Michel Therin ,  Nicolas Prost

IPC: A61F2/00

CPC classification number: A61F2/0063 ,  A61F2002/0068 ,  A61F2002/009 ,  A61F2210/0076 ,  A61F2220/0058 ,  A61F2230/0019 ,  A61F2240/00 ,  A61F2250/0051

Abstract: The present invention relates to a prosthesis (1) for hernia repair comprising a reinforcement layer (2), a first barrier layer (3) of anti-adhesion material covering at least a part of a surface of the reinforcement layer, and a second barrier layer of anti-adhesion material covering a remaining part of the surface of the reinforcement layer, the second barrier layer being formed of one or more flap member(s) (4).

公开(公告)号：US09527929B2

公开(公告)日：2016-12-27

申请号：US14596672

申请日：2015-01-14

Applicant: Sofradim Production

Inventor： Sebastien Francois ,  Sebastien Ladet ,  Muriel Guerin

IPC: C08B37/08 ,  C07H1/08

CPC classification number: C08B37/003 ,  C07H1/08

Abstract: The present invention relates to a method for the preparation of chitosan of a degree of acetylation DAr, from chitosan β having a degree of acetylation DAi lower than DAr, comprising at least one step of purification and at least one step of acetylation of said chitosan β, said purification step comprising at least one step of solubilization of said chitosan β in an acidic aqueous medium and at least one step of precipitation of said thus solubilized chitosan, wherein said acetylation step is carried out in a solution on said solubilized chitosan before said precipitation step.

Abstract translation: 具有高乙酰化度的壳聚糖的制备方法本发明涉及由具有乙酰化度DA的壳聚糖f3制备乙酰化度DA r的壳聚糖的方法; 包括至少一个纯化步骤和所述壳聚糖2的至少一个乙酰化步骤，所述纯化步骤包括将所述壳聚糖f 3溶解在酸性水性介质中的至少一个步骤和至少一个沉淀步骤 的所述溶解的壳聚糖，其中所述乙酰化步骤在所述沉淀步骤之前在所述溶解的壳聚糖上的溶液中进行，所述沉淀步骤包括病毒失活步骤。

公开(公告)号：US20150210780A1

公开(公告)日：2015-07-30

申请号：US14596672

申请日：2015-01-14

Applicant: Sofradim Production

Inventor： Sebastien Francois ,  Sebastien Ladet ,  Muriel Guerin

IPC: C08B37/08

CPC classification number: C08B37/003 ,  C07H1/08

Abstract: The present invention relates to a method for the preparation of chitosan of a degree of acetylation DAr, from chitosan β having a degree of acetylation DAi lower than DAr, comprising at least one step of purification and at least one step of acetylation of said chitosan β, said purification step comprising at least one step of solubilization of said chitosan β in an acidic aqueous medium and at least one step of precipitation of said thus solubilized chitosan, wherein said acetylation step is carried out in a solution on said solubilized chitosan before said precipitation step.

Abstract translation: 本发明涉及一种从壳聚糖和bgr制备乙酰化度DAr的壳聚糖的方法。 具有低于DAr的乙酰化度DAi，其包含至少一个纯化步骤和所述壳聚糖和bgr的至少一个乙酰化步骤;所述纯化步骤包括至少一个步骤：使所述壳聚糖和bgr的溶解; 在酸性水性介质中和所述溶解的壳聚糖沉淀的至少一个步骤，其中所述乙酰化步骤在所述沉淀步骤之前在所述溶解的壳聚糖的溶液中进行。