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公开(公告)号：US20180071385A1
公开(公告)日：2018-03-15
申请号：US15705333
申请日：2017-09-15
Applicant: Leidos, Inc.
Inventor： Gabriel M. Gutierrez , Vinayaka Kotraiah , James Pannucci , Ramses Ayala
IPC: A61K39/39 , A61K38/16 , A61K39/00 , A61K39/015
CPC classification number: A61K39/39 , A61K38/10 , A61K38/16 , A61K39/0011 , A61K39/015 , A61K2039/55516 , C07K7/08
Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, treating infectious diseases, enhancing a response to vaccination, and treating sepsis.
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公开(公告)号：US20160176955A1
公开(公告)日：2016-06-23
申请号：US15056458
申请日：2016-02-29
Applicant: Leidos, Inc. , The United States of America, as represented by the Secretary, Dept. of Health and Human Services
Inventor： Gabriel M. Gutierrez , James Pannucci , Amy Noe , Steve Chienwen Huang , Scott Winram , Annie Xiaoyan Mo
IPC: C07K16/20
CPC classification number: C07K16/205 , A61K39/015 , A61K39/39575 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , Y02A50/412
Abstract: This disclosure provides antibodies that are useful for preventing and/or treating malaria. The epitope to which the antibodies bind is in close proximity to the conserved proteolytic cleavage site of P. falciparum circumsporozoite protein (CSP), and the antibodies provided in this disclosure can prevent cleavage and inhibit P. falciparum sporozoites from invading the liver.
Abstract translation: 本公开提供可用于预防和/或治疗疟疾的抗体。 抗体结合的表位紧邻恶性疟原虫环子孢子蛋白（CSP）的保守的蛋白水解切割位点，并且本公开中提供的抗体可以预防切割并抑制恶性疟原虫子孢子侵入肝脏。
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公开(公告)号：US20150158941A1
公开(公告)日：2015-06-11
申请号：US14097799
申请日：2013-12-05
Applicant: Leidos, Inc.
Inventor： Gabriel M. Gutierrez , James Pannucci , Amy Noe , Steve Chienwen Huang , Scott Winram
IPC: C07K16/20 , A61K45/06 , A61K39/395 , A61K39/015
CPC classification number: C07K16/205 , A61K39/015 , A61K39/39575 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , Y02A50/412
Abstract: This disclosure provides antibodies that are useful for preventing and/or treating malaria. The epitope to which the antibodies bind is in close proximity to the conserved proteolytic cleavage site of P. falciparum circumsporozoite protein (CSP), and the antibodies provided in this disclosure can prevent cleavage and inhibit P. falciparum sporozoites from invading the liver.
Abstract translation: 本公开提供可用于预防和/或治疗疟疾的抗体。 抗体结合的表位紧邻恶性疟原虫环子孢子蛋白（CSP）的保守的蛋白水解切割位点，并且本公开中提供的抗体可以预防切割并抑制恶性疟原虫子孢子侵入肝脏。
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公开(公告)号：US11407829B2
公开(公告)日：2022-08-09
申请号：US16879884
申请日：2020-05-21
Applicant: Leidos, Inc.
Inventor： Gabriel M. Gutierrez , Vinayaka Kotraiah , Timothy W. Phares , James Pannucci , Marc Mansour
IPC: A61K39/00 , C07K16/28 , A61K39/395 , A61K45/06 , C12N15/11 , A61K38/16 , C07K14/00 , A61K38/04 , C07K7/08
Abstract: This disclosure provides peptides which bind to LAG3, such as SAPWEPLHWPEDWWQGTGEW (SEQ ID NO:1), and can be used to block the interaction of LAG 3 with other molecules such as MHC-II, FGL1, and α-synuclein. These peptides can be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, or inhibiting the progression of a synucleinopathy, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, and enhancing a response to a vaccine.
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公开(公告)号：US20220112243A1
公开(公告)日：2022-04-14
申请号：US17497069
申请日：2021-10-08
Applicant: Leidos, Inc.
Inventor： Gabriel M. Gutierrez , James Pannucci , Michael Ryan Weil , Timothy W. Phares , Vinayaka Kotraiah , Cecille D. Browne , Peter J. Buontempo
Abstract: This disclosure provides peptides which can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.
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Patent Agency Ranking
公开(公告)号：US20220033441A1
公开(公告)日：2022-02-03
申请号：US17386637
申请日：2021-07-28
Applicant: Leidos, Inc.
Inventor： Gabriel M. Gutierrez , James Pannucci , Vinayaka Kotraiah , Timothy W. Phares , Cecille D. Browne
Abstract: This disclosure provides peptides that bind to LAG3 and can be used to block its interaction with other molecules such as MHC-II, FGL1, and α-synuclein. These peptides, with their demonstrated activity and short half-life, can be used to activate cellular immunity while significantly reducing the potential for adverse events that is often associated with the antibody-based checkpoint inhibitors. The peptides can be used as stand-alone therapeutics or can be used as immune modulators in combination with other therapies.
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公开(公告)号：US10799581B2
公开(公告)日：2020-10-13
申请号：US15908861
申请日：2018-03-01
Applicant: Leidos, Inc.
Inventor： Gabriel M. Gutierrez , Vinayaka Kotraiah , James Pannucci , Ramses Ayala
Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, treating infectious diseases, enhancing a response to vaccination, and treating sepsis.
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公开(公告)号：US20190002545A1
公开(公告)日：2019-01-03
申请号：US16133143
申请日：2018-09-17
Applicant: Leidos, Inc. , The United States of America, as represented by the Secretary, Dept. of Health and Human Services
Inventor： Gabriel M. Gutierrez , James Pannucci , Amy Noe , Steve Chienwen Huang , Scott Winram , Annie Xiaoyan Mo
IPC: C07K16/20 , A61K39/395 , A61K45/06 , A61K39/015
Abstract: This disclosure provides antibodies that are useful for preventing and/or treating malaria. The epitope to which the antibodies bind is in close proximity to the conserved proteolytic cleavage site of P. falciparum circumsporozoite protein (CSP), and the antibodies provided in this disclosure can prevent cleavage and inhibit P. falciparum sporozoites from invading the liver.
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公开(公告)号：US10160802B2
公开(公告)日：2018-12-25
申请号：US15056458
申请日：2016-02-29
Applicant: Leidos, Inc. , The United States of America, as represented by the Secretary, Dept. of Health and Human Services
Inventor： Gabriel M. Gutierrez , James Pannucci , Amy Noe , Steve Chienwen Huang , Scott Winram , Annie Xiaoyan Mo
IPC: A61K39/015 , C07H21/02 , A61K39/02 , C07K16/20 , A61K39/395 , A61K45/06 , A61K39/00
Abstract: This disclosure provides antibodies that are useful for preventing and/or treating malaria. The epitope to which the antibodies bind is in close proximity to the conserved proteolytic cleavage site of P. falciparum circumsporozoite protein (CSP), and the antibodies provided in this disclosure can prevent cleavage and inhibit P. falciparum sporozoites from invading the liver.
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公开(公告)号：US09321834B2
公开(公告)日：2016-04-26
申请号：US14097799
申请日：2013-12-05
Applicant: Leidos, Inc. , The United States of America, as represented by the Secretary, Dept. of Health and Human Services
Inventor： Gabriel M. Gutierrez , James Pannucci , Amy Noe , Steve Chienwen Huang , Scott Winram , Annie Xiaoyan Mo
IPC: A61K39/015 , A61K45/00 , A61K39/395 , C07K16/20 , A61K45/06 , A61K39/00
CPC classification number: C07K16/205 , A61K39/015 , A61K39/39575 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , Y02A50/412
Abstract: This disclosure provides antibodies that are useful for preventing and/or treating malaria. The epitope to which the antibodies bind is in close proximity to the conserved proteolytic cleavage site of P. falciparum circumsporozoite protein (CSP), and the antibodies provided in this disclosure can prevent cleavage and inhibit P. falciparum sporozoites from invading the liver.
Abstract translation: 本公开提供可用于预防和/或治疗疟疾的抗体。 抗体结合的表位紧邻恶性疟原虫环子孢子蛋白（CSP）的保守的蛋白水解切割位点，并且本公开中提供的抗体可以预防切割并抑制恶性疟原虫子孢子侵入肝脏。
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