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    PREPARATION OF CHIRAL AMIDES AND AMINES
    22.
    发明申请
    PREPARATION OF CHIRAL AMIDES AND AMINES 审中-公开
    制备乳酸和氨基酸

    公开(公告)号：US20140057990A1

    公开(公告)日：2014-02-27

    申请号：US13956765

    申请日：2013-08-01

    Applicant: SUNOVION PHARMACEUTICALS INC.

    Inventor： Hang Zhao ,  Stefan G. Koenig ,  Charles P. Vandenbossche ,  Surendra Singh ,  Harold Scott Wilkinson ,  Roger P. Bakale

    IPC: C07C231/14 ,  C07C209/50 ,  C07C211/42 ,  C07C231/12

    CPC classification number: C07C231/14 ,  C07B43/06 ,  C07C209/50 ,  C07C209/62 ,  C07C211/42 ,  C07C231/12 ,  C07C249/08 ,  C07C2602/10

    Abstract: This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure.

    Abstract translation: 本发明提供了将肟转化成烯酰胺的方便方法。 该方法不需要使用金属试剂。 因此，它产生所需化合物，而不伴随产生大量的金属废物。 酰胺是酰胺和胺的有用前体。 本发明提供了将前手性烯酰胺转化成相应的手性酰胺的方法。 在示例性方法中，通过使用手性氢化催化剂在氢化期间引入手性氨基中心。 在选择的实施方案中，本发明提供了制备包括1,2,3,4-四氢-N-烷基-1-萘胺或1,2,3,4-四氢-1-萘胺亚结构的酰胺和胺的方法。

    Nonracemic mixtures and uses thereof
    24.
    发明授权
    Nonracemic mixtures and uses thereof 有权

    公开(公告)号：US11517558B2

    公开(公告)日：2022-12-06

    申请号：US17097799

    申请日：2020-11-13

    Applicant: Sunovion Pharmaceuticals Inc.

    Inventor： Seth Cabot Hopkins ,  Kenneth Stephen Koblan ,  John R. Snoonian ,  Harold Scott Wilkinson

    IPC: A61K31/40 ,  A61P25/24

    Abstract: Provided are compositions comprising unequal mixtures of (R)-amisulpride and (S)-amisulpride, or pharmaceutically acceptable salts thereof, where the amount of (R)-amisulpride is greater than the amount of (S)-amisulpride, compositions and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens. In addition, provided are various formulations thereof, including, but not limited to, formulations employing polymorphs of enantiomeric amisulpride.

    NONRACEMIC MIXTURES AND USES THEREOF
    26.
    发明申请
    NONRACEMIC MIXTURES AND USES THEREOF 审中-公开

    公开(公告)号：US20200237719A1

    公开(公告)日：2020-07-30

    申请号：US16846905

    申请日：2020-04-13

    Applicant: Sunovion Pharmaceuticals Inc.

    Inventor： Seth Cabot Hopkins ,  Kenneth Stephen Koblan ,  John R. Snoonian ,  Harold Scott Wilkinson

    IPC: A61K31/40 ,  A61P25/24

    Abstract: Provided are compositions comprising unequal mixtures of (R)-amisulpride and (S)-amisulpride, or pharmaceutically acceptable salts thereof, where the amount of (R)-amisulpride is greater than the amount of (S)-amisulpride, compositions and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens. In addition, provided are various formulations thereof, including, but not limited to, formulations employing polymorphs of enantiomeric amisulpride.

    NONRACEMIC MIXTURES AND USES THEREOF
    27.
    发明申请
    NONRACEMIC MIXTURES AND USES THEREOF 有权

    公开(公告)号：US20200147040A1

    公开(公告)日：2020-05-14

    申请号：US16738261

    申请日：2020-01-09

    Applicant: Sunovion Pharmaceuticals Inc.

    Inventor： Seth Cabot Hopkins ,  Kenneth Stephen Koblan ,  John R. Snoonian ,  Harold Scott Wilkinson

    IPC: A61K31/40 ,  A61P25/24

    Abstract: Provided are compositions comprising unequal mixtures of (R)-amisulpride and (S)-amisulpride, or pharmaceutically acceptable salts thereof, where the amount of (R)-amisulpride is greater than the amount of (S)-amisulpride, compositions and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens. In addition, provided are various formulations thereof, including, but not limited to, formulations employing polymorphs of enantiomeric amisulpride.

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