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21.发明授权In vitro and In vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine 有权使用噬菌体T4 DNA包装机进行基因和蛋白质的体外和体内递送公开(公告)号：US09187765B2
公开(公告)日：2015-11-17
申请号：US14337545
申请日：2014-07-22
Applicant: The Catholic University of America
Inventor： Venigalla B. Rao
CPC classification number: C12N15/87 , C07K2319/10 , C07K2319/40 , C07K2319/61 , C12N2795/10122 , C12N2795/10123 , C12N2795/10142 , C12N2810/6009 , C12N2810/85 , C12N2810/859
Abstract: Described is T4 DNA packaging machine comprising: one or more DNA molecules packaged in a head of the T4 DNA packaging machine, one or more Hoc-fused proteins displayed on the head of the T4 DNA packaging machine, and one or more Soc-fused proteins displayed on the head of the T4 DNA packaging machine. Also described are methods of making and using such a T4 DNA packaging machine.
Abstract translation: 描述的是T4 DNA包装机，其包括：包装在T4 DNA包装机的头部中的一个或多个DNA分子，显示在T4 DNA包装机头部上的一种或多种Hoc融合蛋白，以及一种或多种Soc-融合蛋白 显示在T4 DNA包装机的头上。 还描述了制备和使用这种T4 DNA包装机的方法。
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22.发明授权In vitro and in vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine 有权使用噬菌体T4 DNA包装机进行基因和蛋白质的体外和体内递送公开(公告)号：US09163262B2
公开(公告)日：2015-10-20
申请号：US14096238
申请日：2013-12-04
Applicant: The Catholic University of America
Inventor： Venigalla B. Rao
CPC classification number: C12N15/87 , C07K2319/10 , C07K2319/40 , C07K2319/61 , C12N2795/10122 , C12N2795/10123 , C12N2795/10142 , C12N2810/6009 , C12N2810/85 , C12N2810/859
Abstract: Described is T4 DNA packaging machine comprising: one or more DNA molecules packaged in a head of the T4 DNA packaging machine, one or more Hoc-fused proteins displayed on the head of the T4 DNA packaging machine, and one or more Soc-fused proteins displayed on the head of the T4 DNA packaging machine. Also described are methods of making and using such a T4 DNA packaging machine.
Abstract translation: 描述的是T4 DNA包装机，其包括：包装在T4 DNA包装机的头部中的一个或多个DNA分子，显示在T4 DNA包装机头部上的一种或多种Hoc融合蛋白，以及一种或多种Soc-融合蛋白 显示在T4 DNA包装机的头上。 还描述了制备和使用这种T4 DNA包装机的方法。
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