公开(公告)号：US11542244B2

公开(公告)日：2023-01-03

申请号：US17056745

申请日：2019-05-17

申请人： KURA ONCOLOGY, INC.

发明人： Pingda Ren ,  Xiaohu Deng ,  Wanping Mai

IPC分类号： C07D401/06

摘要： Provided herein are methods of preparing a desired enantiomer 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl) methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone, otherwise known as tipifarnib.

公开(公告)号：US09624228B2

公开(公告)日：2017-04-18

申请号：US15026581

申请日：2014-10-03

申请人： KURA ONCOLOGY, INC.

发明人： Liansheng Li ,  Tao Wu ,  Jun Feng ,  Pingda Ren ,  Yi Liu

IPC分类号： C07D487/04 ,  A61K31/4439 ,  A61K31/513 ,  C07D471/04 ,  A61K9/00 ,  A61K31/4745 ,  A61K31/5377 ,  A61K31/5517 ,  A61K45/06 ,  C07D519/00

CPC分类号： C07D487/04 ,  A61K9/0053 ,  A61K31/4439 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/5517 ,  A61K45/06 ,  A61P35/00 ,  C07B59/002 ,  C07B2200/05 ,  C07D471/04 ,  C07D519/00

摘要： The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as ERK (MAPK). Also provided are methods of using such compounds or compositions, and methods of using these compositions to modulate the activities of one or more of these kinases, especially for therapeutic applications such as the treatment disorders such as cancer.

公开(公告)号：US20240287023A1

公开(公告)日：2024-08-29

申请号：US18634587

申请日：2024-04-12

申请人： Kura Oncology, Inc.

发明人： Xuefeng Zhu ,  Pingda Ren ,  Zhu Bai ,  Wanting Xiong ,  Dan Xu ,  Yahu Arthur Liu

IPC分类号： C07D401/10 ,  A61P35/00 ,  C07D491/044

CPC分类号： C07D401/10 ,  A61P35/00 ,  C07D491/044

摘要： The present invention relates to macrocyclic compounds of any one of Formula (I), or a pharmaceutically acceptable form thereof, pharmaceutical compositions comprising the same, methods of preparing the same, and methods of treating cancer dependent on a farnesylated protein, using the same.

公开(公告)号：US12018011B2

公开(公告)日：2024-06-25

申请号：US18329479

申请日：2023-06-05

申请人： Kura Oncology, Inc.

发明人： Xuefeng Zhu ,  Pingda Ren ,  Zhu Bai ,  Wanting Xiong ,  Dan Xu ,  Yahu Arthur Liu

IPC分类号： A61P35/00 ,  C07D401/10 ,  C07D491/044

CPC分类号： C07D401/10 ,  A61P35/00 ,  C07D491/044

摘要： The present invention relates to macrocyclic compounds of any one of Formula (I), or a pharmaceutically acceptable form thereof, pharmaceutical compositions comprising the same, methods of preparing the same, and methods of treating cancer dependent on a farnesylated protein, using the same.

公开(公告)号：US20230322711A1

公开(公告)日：2023-10-12

申请号：US18329479

申请日：2023-06-05

申请人： Kura Oncology, Inc.

发明人： Xuefeng Zhu ,  Pingda Ren ,  Zhu Bai ,  Wanting Xiong ,  Dan Xu ,  Yahu Arthur Liu

IPC分类号： C07D401/10 ,  C07D491/044 ,  A61P35/00

CPC分类号： C07D401/10 ,  A61P35/00 ,  C07D491/044

摘要： The present invention relates to macrocyclic compounds of any one of Formula (I), or a pharmaceutically acceptable form thereof, pharmaceutical compositions comprising the same, methods of preparing the same, and methods of treating cancer dependent on a farnesylated protein, using the same.

公开(公告)号：US10301317B2

公开(公告)日：2019-05-28

申请号：US15896929

申请日：2018-02-14

申请人： Kura Oncology, Inc.

发明人： Liansheng Li ,  Tao Wu ,  Jun Feng ,  Pingda Ren ,  Yi Liu

IPC分类号： C07D487/04 ,  A61K31/4439 ,  A61K31/513 ,  C07D471/04 ,  A61K9/00 ,  A61K31/4745 ,  A61K31/5377 ,  A61K31/5517 ,  A61K45/06 ,  C07D519/00 ,  C07B59/00 ,  A61P35/00

摘要： The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as ERK (MAPK). Also provided are methods of using such compounds or compositions, and methods of using these compositions to modulate the activities of one or more of these kinases, especially for therapeutic applications such as the treatment disorders such as cancer.