公开(公告)号：US20220347307A1

公开(公告)日：2022-11-03

申请号：US17705803

申请日：2022-03-28

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Zarna Patel ,  Ashish Sarode ,  Yi Zhang ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K47/64 ,  A61K47/54 ,  A61K47/69 ,  A61K31/7105 ,  C12N15/85

Abstract: The present invention provides, among other things, methods and compositions of formulating nucleic acid-containing nanoparticles for efficient delivery of payload in vivo such that the method and compositions can be used to generate mRNA vaccines.

公开(公告)号：US20200085745A1

公开(公告)日：2020-03-19

申请号：US16553747

申请日：2019-08-28

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Zarna Patel ,  Yi Zhang ,  Ashish Sarode ,  Rebecca L. Ball ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K9/127 ,  A61K9/14 ,  A61K9/51 ,  A61K31/7105

Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.