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公开(公告)号：US08530505B2
公开(公告)日：2013-09-10
申请号：US13360107
申请日：2012-01-27
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/42 , C07D409/14
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
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公开(公告)号：US20130005701A1
公开(公告)日：2013-01-03
申请号：US13360107
申请日：2012-01-27
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/422 , A61K31/5377 , C07D417/14 , A61K31/541 , C07D495/04 , C12N5/078 , A61K31/428 , A61K31/496 , A61K31/444 , A61K31/454 , A61K31/538 , A61K31/5383 , C07D413/14 , A61K31/4365
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
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23.发明授权公开(公告)号：US08129378B2
公开(公告)日：2012-03-06
申请号：US12494879
申请日：2009-06-30
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/5377 , A61K31/42 , C07D409/14
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
摘要翻译： 本发明涉及血液凝固领域。 描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。
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24.发明授权公开(公告)号：US07576111B2
公开(公告)日：2009-08-18
申请号：US11932082
申请日：2007-10-31
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/42 , C07D409/14
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
摘要翻译： 本发明涉及血液凝固领域。 描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。
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公开(公告)号：US20080090815A1
公开(公告)日：2008-04-17
申请号：US11932082
申请日：2007-10-31
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/541 , A61K31/421 , A61K31/4453 , A61P9/10 , C07D401/14 , C07D417/14 , C07D413/14 , C07D263/02 , A61P9/00 , A61K31/5355
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
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公开(公告)号：US20050004207A1
公开(公告)日：2005-01-06
申请号：US10484369
申请日：2002-07-03
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Stephan Jordan , Elisabeth Perzborn , Karl-Heinz Schlemmer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Stephan Jordan , Elisabeth Perzborn , Karl-Heinz Schlemmer
IPC分类号： C07D473/00 , A61K31/4025 , A61K31/4035 , A61K31/4155 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/52 , A61K31/5377 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P19/02 , A61P25/28 , A61P35/00 , C07D209/46 , C07D209/48 , C07D213/81 , C07D409/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/14 , C07D521/00 , A61K31/4015 , C07D207/40
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D409/12 , C07D409/14 , C07D471/14
摘要： The invention relates to the field of blood clotting, to novel compounds of formula (I), to a method for their production and to the use of these compounds as active ingredients in medicaments for preventing and/or treating diseases. The compounds are factor Xa inhibitors.
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公开(公告)号：US07767702B2
公开(公告)日：2010-08-03
申请号：US10481297
申请日：2002-06-07
申请人： Alexander Straub , Thomas Lampe , Josef Pernerstorfer , Elisabeth Perzborn , Jens Pohlmann , Susanne Röhrig , Karl-Heinz Schlemmer
发明人： Alexander Straub , Thomas Lampe , Josef Pernerstorfer , Elisabeth Perzborn , Jens Pohlmann , Susanne Röhrig , Karl-Heinz Schlemmer
IPC分类号： A61K31/421
CPC分类号： A61K31/422 , A61K31/421 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The invention relates to combinations of A) oxazolidinones of formula (I) and B) other active ingredients, to a method for producing said combinations and to the use thereof as medicaments, in particular for the treatment and/or prophylaxis of thrombo-embolic diseases.
摘要翻译： 本发明涉及式（I）的A）恶唑烷酮和B）其它活性成分的组合，用于制备所述组合的方法及其作为药物的用途，特别是用于治疗和/或预防血栓栓塞性疾病 。
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28.发明申请公开(公告)号：US20080200674A1
公开(公告)日：2008-08-21
申请号：US12027553
申请日：2008-02-07
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： C07D413/14
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
摘要翻译： 本发明涉及血液凝固领域。 描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。
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29.发明申请公开(公告)号：US20060258724A1
公开(公告)日：2006-11-16
申请号：US11460529
申请日：2006-07-27
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/422 , C07D413/02
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
摘要翻译： 本发明涉及血液凝固领域。 描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。
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公开(公告)号：US06933295B2
公开(公告)日：2005-08-23
申请号：US10484369
申请日：2002-07-03
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Stephan Jordan , Elisabeth Perzborn , Karl-Heinz Schlemmer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Stephan Jordan , Elisabeth Perzborn , Karl-Heinz Schlemmer
IPC分类号： C07D473/00 , A61K31/4025 , A61K31/4035 , A61K31/4155 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/52 , A61K31/5377 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P19/02 , A61P25/28 , A61P35/00 , C07D209/46 , C07D209/48 , C07D213/81 , C07D409/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/14 , C07D521/00 , C07D487/04
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D409/12 , C07D409/14 , C07D471/14
摘要： The invention relates to the field of blood clotting, to novel compounds of formula (I), to a method for their production and to the use of these compounds as active ingredients in medicaments for preventing and/or treating diseases. The compounds are factor Xa inhibitors.
摘要翻译： 本发明涉及血液凝固领域，关于式（I）的新化合物，其制备方法和这些化合物作为用于预防和/或治疗疾病的药物中的活性成分的用途。 化合物是因子Xa抑制剂。
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