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1.发明申请公开(公告)号：US20100041646A1
公开(公告)日：2010-02-18
申请号：US12084267
申请日：2006-10-20
申请人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer
发明人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer
IPC分类号： A61K31/422 , C07D413/14 , A61K31/5355 , A61P7/02 , C12N5/00
CPC分类号： C07D413/14
摘要： The present application relates to novel 1,4-phenylene-bis-oxazolidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
摘要翻译： 本申请涉及新的1,4-亚苯基 - 双恶唑烷衍生物，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防的药物的用途 的疾病，特别是血栓栓塞性疾病。
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公开(公告)号：US20080214533A1
公开(公告)日：2008-09-04
申请号：US11792108
申请日：2005-11-22
申请人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Arounarith Tuch , Mario Lobell , Peter Nell , Nils Burkhardt
发明人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Arounarith Tuch , Mario Lobell , Peter Nell , Nils Burkhardt
IPC分类号： A61K31/5355 , C07D401/14 , C07D413/14 , A61K31/4439 , C07D417/14 , A61K31/497 , A61P7/00
CPC分类号： C07D413/14
摘要： The invention relates to novel cyclic iminocarbamates of formula (I), wherein R1, R2, R3, A, Z, and n have the meanings recited in the description, to a method for the production thereof, to pharmaceutical compositions containing such materials, and to methods for the treatment and/or prophylaxis of thromboembolic diseases using them.
摘要翻译： 本发明涉及式（I）的新型环状亚氨基化物，其中R 1，R 2，R 3，A，Z和n 具有本说明书中所述的含义，其制备方法，含有这些材料的药物组合物，以及使用它们治疗和/或预防血栓栓塞性疾病的方法。
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3.发明申请公开(公告)号：US20080200674A1
公开(公告)日：2008-08-21
申请号：US12027553
申请日：2008-02-07
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： C07D413/14
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
摘要翻译： 本发明涉及血液凝固领域。 描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。
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公开(公告)号：US20060287315A1
公开(公告)日：2006-12-21
申请号：US11299342
申请日：2005-12-08
申请人： Susanne Rohrig , Mario Jeske , Metin Akbaba , Ulrich Rosentreter , Stephen Boyer , Karin Fischer , Jens Pohlmann , Arounarith Tuch , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Nils Burkhardt , Swen Allerheiligen , Peter Nell , Sabine Arndt , Mario Lobell
发明人： Susanne Rohrig , Mario Jeske , Metin Akbaba , Ulrich Rosentreter , Stephen Boyer , Karin Fischer , Jens Pohlmann , Arounarith Tuch , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Nils Burkhardt , Swen Allerheiligen , Peter Nell , Sabine Arndt , Mario Lobell
IPC分类号： A61K31/5377 , A61K31/497 , C07D413/02 , C07D403/02
CPC分类号： C07D491/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14
摘要： The present invention relates to novel pyridinedicarboxamides, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
摘要翻译： 本发明涉及新的吡啶二酰胺，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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5.发明申请公开(公告)号：US20060258724A1
公开(公告)日：2006-11-16
申请号：US11460529
申请日：2006-07-27
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/422 , C07D413/02
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
摘要翻译： 本发明涉及血液凝固领域。 描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。
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6.发明授权公开(公告)号：US07576111B2
公开(公告)日：2009-08-18
申请号：US11932082
申请日：2007-10-31
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/42 , C07D409/14
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
摘要翻译： 本发明涉及血液凝固领域。 描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。
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公开(公告)号：US20080090815A1
公开(公告)日：2008-04-17
申请号：US11932082
申请日：2007-10-31
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/541 , A61K31/421 , A61K31/4453 , A61P9/10 , C07D401/14 , C07D417/14 , C07D413/14 , C07D263/02 , A61P9/00 , A61K31/5355
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
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公开(公告)号：US20050004207A1
公开(公告)日：2005-01-06
申请号：US10484369
申请日：2002-07-03
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Stephan Jordan , Elisabeth Perzborn , Karl-Heinz Schlemmer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Stephan Jordan , Elisabeth Perzborn , Karl-Heinz Schlemmer
IPC分类号： C07D473/00 , A61K31/4025 , A61K31/4035 , A61K31/4155 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/52 , A61K31/5377 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P19/02 , A61P25/28 , A61P35/00 , C07D209/46 , C07D209/48 , C07D213/81 , C07D409/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/14 , C07D521/00 , A61K31/4015 , C07D207/40
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D409/12 , C07D409/14 , C07D471/14
摘要： The invention relates to the field of blood clotting, to novel compounds of formula (I), to a method for their production and to the use of these compounds as active ingredients in medicaments for preventing and/or treating diseases. The compounds are factor Xa inhibitors.
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公开(公告)号：US20100184767A1
公开(公告)日：2010-07-22
申请号：US12665727
申请日：2008-06-07
申请人： Susanne Rohrig
发明人： Susanne Rohrig
IPC分类号： A61K31/5377 , C07D413/14 , A61K31/454 , A61K31/513 , A61P29/00 , A61P31/04 , A61P11/00 , A61P7/02
CPC分类号： C07D409/12 , C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
摘要翻译： 本发明涉及新的取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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公开(公告)号：US07592339B2
公开(公告)日：2009-09-22
申请号：US11460529
申请日：2006-07-27
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/5377 , C07D409/14
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
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