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    House dust mite allergen, Der f VII, and uses therefor
    21.
    发明授权
    House dust mite allergen, Der f VII, and uses therefor 失效

    公开(公告)号：US06413738B1

    公开(公告)日：2002-07-02

    申请号：US08553336

    申请日：1996-06-10

    申请人： Wayne Robert Thomas ,  Kaw-Yan Chua

    发明人： Wayne Robert Thomas ,  Kaw-Yan Chua

    IPC分类号： C12P2106

    CPC分类号： C07K14/43531 ,  A61K38/00 ,  C07K14/7051 ,  C07K2319/00 ,  G01N33/56966 ,  G01N33/6893 ,  G01N2800/24 ,  Y10S530/868

    摘要： Isolated nucleic acids encoding allergens of the species Dermatophagoides pteronyssinus and Dermatophagoides farinae, Der p VII and Der f VII, respectively, are disclosed. A cDNA encoding a peptide having a Der p VII activity and a predicted molecular weight of about 22, 177 daltons is described. A cDNA encoding a peptide having Der f VII activity is also described. The nucleic acids of the invention can be used as probes to detect the presence of Der p VII or Der f VII nucleic acid in a sample or for the recombinant production of peptides having a Der p VII or Der f VII activity. Peptides having a Der p VII or Der f VII activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mite allergens.

    Recombinant eukaryotic plasmids containing allergen-gene and use thereof for the prevention and/or treatment of allergic diseases
    22.
    发明授权
    Recombinant eukaryotic plasmids containing allergen-gene and use thereof for the prevention and/or treatment of allergic diseases 失效
    含有过敏原基因的重组真核质粒及其用于预防和/或治疗过敏性疾病的用途

    公开(公告)号：US06251663B1

    公开(公告)日：2001-06-26

    申请号：US09166967

    申请日：1998-10-06

    申请人： Ching-Hsiang Hsu ,  Kaw-Yan Chua ,  Mi-Hua Tao ,  Kue-Hsiung Hsieh

    发明人： Ching-Hsiang Hsu ,  Kaw-Yan Chua ,  Mi-Hua Tao ,  Kue-Hsiung Hsieh

    IPC分类号： A61K3170

    CPC分类号： A61K39/35 ,  A61K2039/53

    摘要： The present invention relates to recombinant eukaryotic plasmids comprising an eukaryotic expression vector and an allergen gene for the prevention and/or treatment of allergic diseases. When the recombinant vector containing allergen-gene administrate to an individual in need of such prevention and/or treatment by intramuscular injection, intranasal delivery or intratracheal delivery, the production of allergen-specific IgE synthesis can be inhibited. The invention also relates to the pharmaceutical compositions comprising the the recombinant vector for use in the the prevention and/or treatment of allergic diseases and the production of allergen-specific IgE synthesis. A method for the prevention and/or treatment of allergic diseases is also provided.

    摘要翻译： 本发明涉及包含真核表达载体和用于预防和/或治疗过敏性疾病的变应原基因的重组真核质粒。 当含有变应原基因的重组载体通过肌内注射，鼻内递送或气管内递送需要这种预防和/或治疗的个体时，可以抑制过敏原特异性IgE合成的产生。 本发明还涉及包含用于预防和/或治疗过敏性疾病和产生变应原特异性IgE合成的重组载体的药物组合物。 还提供了用于预防和/或治疗过敏性疾病的方法。

    Cloning and sequencing of allergens of dermatophagoides (house dust mite)
    23.
    发明申请
    Cloning and sequencing of allergens of dermatophagoides (house dust mite) 审中-公开
    皮肤癣菌过敏原（室内尘螨）的克隆和测序

    公开(公告)号：US20060008873A1

    公开(公告)日：2006-01-12

    申请号：US10746909

    申请日：2003-12-23

    申请人： Wayne Thomas ,  Kaw-Yan Chua

    发明人： Wayne Thomas ,  Kaw-Yan Chua

    IPC分类号： C12P21/00

    CPC分类号： C07K14/43531 ,  A61K38/00 ,  C07K14/5403

    摘要： Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagolides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major D. farinae allergens, Der f I and Der f II and DNA encoding a D. pteronyssinus allergen, Der p I. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens.

    摘要翻译： 编码Dermatophagoides（房尘螨）的变应原的分离的DNA，特别是Dermatophagoides farinae和Dermatophagolides pteronyssinus的物种，其是包括蛋白质变应原的至少一个表位的蛋白质过敏原或肽。 特别地，编码两个主要的D. farinae过敏原的DNA，Der f I和Der f II以及编码D.pteronyssinus变应原的DNA，Der p I.另外，由分离的DNA编码的蛋白质或肽，它们用作诊断和 诊断和治疗房屋尘螨过敏原敏感性的治疗试剂和方法。

    Cloning and sequencing of allergens of dermatophagoides (house dust mite)
    24.
    发明授权
    Cloning and sequencing of allergens of dermatophagoides (house dust mite) 失效
    皮肤癣菌过敏原（室内尘螨）的克隆和测序

    公开(公告)号：US06086897A

    公开(公告)日：2000-07-11

    申请号：US465093

    申请日：1995-06-05

    申请人： Wayne Robert Thomas ,  Kaw-Yan Chua

    发明人： Wayne Robert Thomas ,  Kaw-Yan Chua

    IPC分类号： A61K39/35 ,  A61K38/00 ,  A61K39/36 ,  A61K49/00 ,  A61P37/08 ,  C07H21/04 ,  C07K14/00 ,  C07K14/435 ,  C07K14/54 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  G01N33/53 ,  G01N33/569

    CPC分类号： C07K14/43531 ,  C07K14/5403 ,  A61K38/00

    摘要： Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major D. farinae allergens, Der f I and Der f II and DNA encoding a D. pteronssinus allergen, Der p I. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens.

    摘要翻译： 编码Dermatophagoides（房尘螨）变应原的分离的DNA，特别是Dermatophagoides farinae和Dermatophagoides pteronyssinus，它们是蛋白质过敏原或包括蛋白质变应原的至少一个表位的肽。 特别地，编码两个主要的D. farinae变应原的Der DNA和Der f II以及编码D.pteronssinus变应原Der P的DNA。另外，由分离的DNA编码的蛋白质或肽，它们用作诊断和 诊断和治疗房屋尘螨过敏原敏感性的治疗试剂和方法。