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公开(公告)号：US20130006203A1
公开(公告)日：2013-01-03
申请号：US13581166
申请日：2011-02-23
IPC分类号： A61M35/00
CPC分类号： A61K31/138 , A61F13/02 , A61F13/0253 , A61F13/0259 , A61F2013/00646 , A61K9/703 , A61K9/7053
摘要： The invention is intended to provide an adhesive patch which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing of bisoprolol or a salt thereof from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.
摘要翻译： 本发明旨在提供一种粘合贴剂，其有效地抑制在储存期间粘合剂贴剂的粘合剂层的暴露区域渗出或粘附粘合剂层组分的发生以及比索洛尔或 其粘合剂层，从而防止药物含量的降低。 构成粘合片的支持体，剥离衬垫和粘合剂层各自形成为矩形平面形状，并且整个粘合贴片形成为矩形平面形状，并且在支撑体的支撑侧表面上形成突起部 在其角落处的粘合剂贴剂。 此外，粘合贴片可以形成为具有中间部分和周边部分，并且凸起部分可以形成在矩形中间部分的角部。 此外，在相邻的至少两个突出部之间，可以提供连接组装部分，其中粘合贴片的厚度小于突出部分中的粘合贴片的厚度。 在剥离衬垫具有分割部分的情况下，分割部分被制成不穿过突出部分。
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公开(公告)号：US08251213B2
公开(公告)日：2012-08-28
申请号：US12167085
申请日：2008-07-02
IPC分类号： A61B17/06
CPC分类号： A61F15/001 , A61F13/551 , A61F2013/00165 , A61F2013/00365 , Y10T428/13
摘要： The present invention relates to a patch package structure which includes: a package including a first sheet material and a second sheet material, the first and second sheet materials being sealed together in peripheral parts thereof; and a patch disposed in the package, the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer, the release liner having on a surface thereof a cut line supporting a peel-off of the release liner at the time of using the patch, the patch being disposed in the package so that the release liner faces the inner surface of the first sheet material, the first sheet material having a first region in which the inner surface of the first sheet material faces the cut line of the release liner, the first sheet material having in the first region a minimum first distance between the inner surface of the first sheet material and the surface of the release liner, and the inner surface of the first sheet material being spaced from the surface of the release liner at the minimum first distance in the first region.
摘要翻译： 贴片包装结构技术领域本发明涉及一种贴片包装结构，其包括：包括第一片材和第二片材的封装，所述第一片材和第二片材在其周边部分被密封在一起; 以及布置在所述包装中的贴片，所述贴片包含背衬，层压在所述背衬的至少一侧上的压敏粘合剂层以及保护所述压敏粘合剂层的压敏粘合剂表面的剥离衬垫， 所述剥离衬垫在其表面上具有在使用所述贴片时支撑所述剥离衬垫剥离的切割线，所述贴片设置在所述包装中，使得所述剥离衬垫面向所述第一片材的内表面， 所述第一片材具有第一区域，其中所述第一片材的内表面面向所述剥离衬垫的切割线，所述第一片材在所述第一区域中具有所述第一片材的内表面与所述第一片材的内表面之间的最小第一距离， 释放衬垫的表面，并且第一片材的内表面在第一区域中以最小第一距离与释放衬垫的表面间隔开。
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公开(公告)号：US08146741B2
公开(公告)日：2012-04-03
申请号：US12618931
申请日：2009-11-16
IPC分类号： A61B17/06
CPC分类号： B65D75/366 , B65D2215/00
摘要： A blister package comprises a blister and a cover sheet, and the blister has a groove formed in an outer edge section of the blister. The outer edge section of the blister includes an outer region and an inner region, the groove is formed on the inward side of the outer region, and the inner region is formed on the inward side of the groove. The peel strength between the outer region and the cover sheet is greater than the tear strength of the cover sheet, and the peel strength between the inner region and cover sheet is smaller than the tear strength of the cover sheet.
摘要翻译： 泡罩包装件包括泡罩和盖片，并且泡罩具有形成在泡罩的外边缘部分中的凹槽。 泡罩的外缘部分包括外部区域和内部区域，凹槽形成在外部区域的内侧，并且内部区域形成在凹槽的内侧。 外部区域和覆盖片之间的剥离强度大于覆盖片的撕裂强度，并且内部区域和覆盖片材之间的剥离强度小于覆盖片材的撕裂强度。
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公开(公告)号：US09005174B2
公开(公告)日：2015-04-14
申请号：US13581079
申请日：2011-02-23
摘要： The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.
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公开(公告)号：US20120323191A1
公开(公告)日：2012-12-20
申请号：US13581079
申请日：2011-02-23
IPC分类号： A61M35/00
CPC分类号： A61K9/7061 , A61F2013/00651 , A61K9/7023 , A61K9/703 , A61K9/7053
摘要： The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.
摘要翻译： 本发明旨在提供一种粘合贴片，其包含除比索洛尔以外的药物，并且其有效地抑制在保存期间从粘合剂贴剂的粘合剂层的暴露区域渗出或渗出粘合剂层组分的发生以及 从粘合剂层渗出药物的发生，从而防止药物含量的降低。 构成粘合片的支持体，剥离衬垫和粘合剂层各自形成为矩形平面形状，并且整个粘合贴片形成为矩形平面形状，并且在支撑体的支撑侧表面上形成突起部 在其角落处的粘合剂贴剂。 此外，粘合贴片可以形成为具有中间部分和周边部分，并且凸起部分可以形成在矩形中间部分的角部。 此外，在相邻的至少两个突出部之间，可以提供连接组装部分，其中粘合贴片的厚度小于突出部分中的粘合贴片的厚度。 在剥离衬垫具有分割部分的情况下，分割部分被制成不穿过突出部分。
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公开(公告)号：US20140158571A1
公开(公告)日：2014-06-12
申请号：US14232358
申请日：2012-07-13
申请人： Kensuke Matsuoka , Yoshihiro Iwao , Jun Harima , Masakatsu Konno , Kazuhiro Aoyagi , Tomoya Tanaka , Mikio Toyota , Yasuhiko Akita , Tadashi Matsui
发明人： Kensuke Matsuoka , Yoshihiro Iwao , Jun Harima , Masakatsu Konno , Kazuhiro Aoyagi , Tomoya Tanaka , Mikio Toyota , Yasuhiko Akita , Tadashi Matsui
IPC分类号： A61J1/00
CPC分类号： A61J1/00 , A61F13/00076 , A61F2013/00646 , A61F2013/00906
摘要： A packaging structure (100) for a patch includes a first and second base materials (120, 130) which have a peripheral edge part laminated with each other, and the patch is included therein. The first and second base materials (120, 130) have a first to forth sides (121 to 124, 131-134). At least one of the first and second base materials (120, 130) has a first to third opening parts (125 to 127, 135 to 137). The first to third opening parts (125 to 127, 135 to 137) guides so as to open toward the inner peripheral edge (120c1, 120c2, 120c4, 130c1, 130c2, 130c4) of the sealing part (120c, 130c).
摘要翻译： 用于贴片的包装结构（100）包括具有彼此层压的周缘部分的第一和第二基底材料（120,130），并且其中包括贴片。 第一和第二基材（120,130）具有第一至第四侧（121至124,131-134）。 第一和第二基底材料（120,130）中的至少一个具有第一至第三开口部分（125至127,135至137）。 第一至第三开口部（125〜127,135〜137）引导朝向密封部（120c，130c）的内周缘（120c1,120c2,120c4,130c1,130c2,130c4）开口。
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公开(公告)号：US08703178B2
公开(公告)日：2014-04-22
申请号：US12528194
申请日：2008-03-06
IPC分类号： A61K9/70 , A61K31/138 , A61P9/00
CPC分类号： A61K31/138 , A61K9/7053 , A61K9/7061
摘要： The present invention relates to a percutaneous administration device of bisoprolol, which includes a backing; and a pressure-sensitive adhesive layer containing bisoprolol, which is laminated on one surface of the backing, wherein the maximum value of a release rate of bisoprolol during a period of from immediately after the application on skin until a lapse of 24 hours is 30 μg/cm2/hr or less; and wherein the release rate of bisoprolol at the time of a lapse of 24 hours after the application on skin is 10 μg/cm2/hr or less. The percutaneous administration device of the present invention is reduced in the skin irritation during the application, especially at the time of peeling, and is capable of persistently administrating a therapeutically or preventively effective amount of bisoprolol into a living body.
摘要翻译： 本发明涉及比索洛尔的经皮给药装置，其包括背衬; 以及层压在背衬的一个表面上的含有比索洛尔的压敏粘合剂层，其中在施用于皮肤上直到24小时之后的期间，比索洛尔的释放速率的最大值为30μg / cm 2 / hr以下; 并且其中在皮肤上施用后24小时时比索洛尔的释放速率为10μg/ cm 2 / hr以下。 本发明的经皮给药装置，特别是剥离时，皮肤刺激性降低，能够将治疗或预防有效量的比索洛尔施用于生物体。
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公开(公告)号：US09811584B2
公开(公告)日：2017-11-07
申请号：US14235151
申请日：2012-05-01
IPC分类号： G06F17/30
CPC分类号： G06F17/30648 , G06F17/30386 , G06F17/30675
摘要： An information retrieval method for retrieving documents relevant to a user's search inquiry from documents stored in the storage device using an arithmetic operation. The method includes receiving from a user a search query including a plurality of keywords, calculating relevance to a plurality of documents on the basis of the plurality of keywords and the influence set for each keyword, and displaying on the display device documents in the order of relevance. The method also includes displaying on the display device the influence set for each keyword, receiving changes to the displayed influence by the user, and recalculating the relevance on the basis of a change to the influence and displaying on the display device documents in the order of relevance.
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公开(公告)号：US09433533B2
公开(公告)日：2016-09-06
申请号：US11972910
申请日：2008-01-11
CPC分类号： A61F13/0203 , A61F13/551 , A61F15/001
摘要： The present invention provides a patch package structure, which includes: a package including a first sheet material which is planar and a second sheet material which has been molded, the first and second sheet materials being sealed together in peripheral parts thereof, and a patch disposed in the package, in which the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer; the second sheet material has been molded so as to have a protrudent part in at least a substantially central area thereof, the protrudent part having a planar outer shape larger than a planar outer shape of the release liner and having at least one recessed part; d is not smaller than T, in which d is the minimum gap distance between the inner surface of the first sheet material and the inner surface of the second sheet material at the recessed part and T is a thickness of the patch; and, at the boundary between the sealed part where the first and second sheet materials are sealed together and an unsealed part, the outer surface of the second sheet material rises at an obtuse angle.
摘要翻译： 本发明提供了一种贴片包装结构，其包括：包括平面的第一片材和已经模制的第二片材的封装，第一和第二片材在其周边部分被密封在一起，并且贴片布置 在其中贴片包含背衬的包装中，层压在背衬的至少一侧上的压敏粘合剂层和保护压敏粘合剂层的压敏粘合剂表面的剥离衬垫; 第二片材已经被模制成在其至少大致中心区域具有突出部分，突出部分具有比剥离衬垫的平面外形大的平面外形，并且具有至少一个凹部; d不小于T，其中d是第一片材的内表面和凹陷部分的第二片材的内表面之间的最小间隙距离，T是贴片的厚度; 并且在第一和第二片材密封在一起的密封部分与未密封部分之间的边界处，第二片材的外表面以钝角上升。
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公开(公告)号：US09326952B2
公开(公告)日：2016-05-03
申请号：US13581079
申请日：2011-02-23
CPC分类号： A61K9/7061 , A61F2013/00651 , A61K9/7023 , A61K9/703 , A61K9/7053
摘要： The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.
摘要翻译： 本发明旨在提供一种粘合贴片，其包含除比索洛尔以外的药物，并且其有效地抑制在保存期间从粘合剂贴剂的粘合剂层的暴露区域渗出或渗出粘合剂层组分的发生以及 从粘合剂层渗出药物的发生，从而防止药物含量的降低。 构成粘合片的支持体，剥离衬垫和粘合剂层各自形成为矩形平面形状，并且整个粘合贴片形成为矩形平面形状，并且在支撑体的支撑侧表面上形成突出部 在其角落处的粘合剂贴剂。 此外，粘合贴片可以形成为具有中间部分和周边部分，并且凸起部分可以形成在矩形中间部分的角部。 此外，在相邻的至少两个突出部之间，可以提供连接组装部分，其中粘合贴片的厚度小于突出部分中的粘合贴片的厚度。 在剥离衬垫具有分割部分的情况下，分割部分被制成不穿过突出部分。
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