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公开(公告)号:US4133952A
公开(公告)日:1979-01-09
申请号:US805496
申请日:1977-06-10
申请人: David T. Hill , Ivan Lantos , Blaine M. Sutton
发明人: David T. Hill , Ivan Lantos , Blaine M. Sutton
IPC分类号: C07H5/10 , A61K31/70 , A61K31/7135 , A61P29/00 , C07H23/00
CPC分类号: C07H23/00
摘要: The S-gold salt of 2,3,4,6-tetra-O-acetyl-1-thio-.beta.-D-glucopyranose reacts with triethylphosphine in an organic solvent to produce auranofin.
摘要翻译: 2,3,4,6-四-O-乙酰基-1-硫代-β-D-吡喃葡萄糖的S-金盐与有机溶剂中的三乙基膦反应以产生蓝藻酰。
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公开(公告)号:US4125710A
公开(公告)日:1978-11-14
申请号:US811794
申请日:1977-06-30
申请人: David T. Hill , Ivan Lantos , Blaine M. Sutton
发明人: David T. Hill , Ivan Lantos , Blaine M. Sutton
IPC分类号: C07H23/00
CPC分类号: C07H23/00
摘要: Bis(triethylphosphine)gold salts are advantageous agents for preparing auranofin.
摘要翻译: 双(三乙基膦)金盐是制备蓝藻苷的有利试剂。
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公开(公告)号:US4124759A
公开(公告)日:1978-11-07
申请号:US812016
申请日:1977-06-30
申请人: David T. Hill , Ivan Lantos , Blaine M. Sutton
发明人: David T. Hill , Ivan Lantos , Blaine M. Sutton
CPC分类号: C07H23/00
摘要: Auranofin is prepared by direct O-acetylation of S-triethylphosphinegold 1-thio-.beta.-D-glucopyranoside.
摘要翻译: Auranofin通过S-三乙基膦基金1-硫代-β-D-吡喃葡萄糖苷的直接O-乙酰化制备。
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公开(公告)号:US4915232A
公开(公告)日:1990-04-10
申请号:US354786
申请日:1989-05-18
IPC分类号: A47G11/00
CPC分类号: A47G11/00
摘要: The invention disclosed is a picnic mat, multipurpose tote bag and securing means assembly suitable for use by a group of people for picnics and concerts etc. The picnic mat is provided with loops on the underside corners as well as corresponding ground securing devices or pins for holding said mat to the ground. Also provided is a pin manipulating tool to facilitate the insertion in and removal of said pins from the ground without damage to the picnic mat. This invention is also provided with a multipurpose tote bag with an inner pouch for containing said pins and a restraining strap for said manipulating tool.
摘要翻译: 所公开的发明是野餐垫,多用途手提袋和固定装置组合件,适用于一群人用于野餐和音乐会等。野餐垫在下侧角上设置有环,以及相应的地面固定装置或销 把垫子抱在地上。 还提供了一种针操作工具,以便于在不损坏野餐垫的情况下将所述销插入和移出所述销。 本发明还提供一种多用途手提袋,其具有用于容纳所述销的内袋和用于所述操纵工具的约束带。
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公开(公告)号:US4902675A
公开(公告)日:1990-02-20
申请号:US848670
申请日:1986-04-04
申请人: David T. Hill , Randall K. Johnson
发明人: David T. Hill , Randall K. Johnson
IPC分类号: C07F9/50 , C07F9/58 , C07F9/655 , C07F9/6553 , C07H23/00
CPC分类号: C07H23/00 , C07F9/5045 , C07F9/587 , C07F9/65515 , C07F9/655345
摘要: 2-pyridyl and 4-pyridyl phosphine gold compounds of the formula: ##STR1## and 2-pyridyl phosphine gold compounds of the formula: ##STR2## and pharmaceutical compositions containing an effective, tumor cell growth-inhibiting amount of such a compound.
摘要翻译: 具有下式的下式的2-吡啶基和4-吡啶基膦金化合物:下式和下式的2-吡啶基膦金化合物和含有有效的肿瘤细胞生长抑制量的这种化合物的药物组合物。
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公开(公告)号:US4698422A
公开(公告)日:1987-10-06
申请号:US849078
申请日:1986-04-04
申请人: David T. Hill , Randall K. Johnson
发明人: David T. Hill , Randall K. Johnson
CPC分类号: C07H23/00 , C07F9/5045
摘要: Triphos and tetraphos gold compounds which have tumor cell growth-inhibiting activity, pharmaceutical compositions containing an effective, tumor cell growth-inhibiting amount of such a compound or its corresponding triphos or tetraphos ligand, and a method for treating tumor cells sensitive to such a compound or its corresponding triphos or tetraphos ligand.
摘要翻译: 具有肿瘤细胞生长抑制活性的Triphos和tetraphos金化合物,含有有效的肿瘤细胞生长抑制量的这种化合物或其相应的三磷酸或四磷配体的药物组合物,以及治疗对这种化合物敏感的肿瘤细胞的方法 或其相应的三磷或四磷配体。
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公开(公告)号:US4200738A
公开(公告)日:1980-04-29
申请号:US789602
申请日:1977-04-21
申请人: David T. Hill , Blaine M. Sutton , Ivan Lantos
发明人: David T. Hill , Blaine M. Sutton , Ivan Lantos
IPC分类号: C07H23/00
CPC分类号: C07H23/00
摘要: A new synthesis of auranofin comprising reacting 2,3,4,6-tetra-O-acetyl-.alpha.-D-glucopyranosyl bromide with a S-(triethylphosphineaurous)thiouronium salt.
摘要翻译: 一种新的氢醌合成,包括使2,3,4,6-四-O-乙酰基-α-D-吡喃葡萄糖基溴与S-(三乙基膦基)硫鎓盐反应。
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公开(公告)号:US4171360A
公开(公告)日:1979-10-16
申请号:US879319
申请日:1978-02-21
申请人: David T. Hill
发明人: David T. Hill
CPC分类号: C07F9/581 , Y10S514/825
摘要: The compounds are (pyridine) (trisubstituted phosphine) gold(I) salts which have antiarthritic activity.
摘要翻译: {PG,1这些化合物是具有抗关节活性的(吡啶)(三取代膦)金(I)盐。
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公开(公告)号:US4131732A
公开(公告)日:1978-12-26
申请号:US789603
申请日:1977-04-21
申请人: David T. Hill , Blaine M. Sutton , Ivan Lantos
发明人: David T. Hill , Blaine M. Sutton , Ivan Lantos
IPC分类号: C07H5/10 , A61K31/7135 , A61P19/02 , C07H23/00
CPC分类号: C07H23/00
摘要: A new synthesis of auranofin comprising reacting 2,3,4,6-tetra-O-acetyl-.alpha.-D-glucopyranosyl bromide with triethylphosphinegold(I) chloride and sodium or potassiumsulfide. Auranofin is an antiarthritic pharmaceutical compound. Auranofin is an orally active therapeutic agent which is useful in man as an antiarthritic.
摘要翻译: 一种新合成的昂兰芬,其包括使2,3,4,6-四-O-乙酰基-α-D-吡喃葡糖基溴与三乙基膦基金(I)氯化物和硫代钠或硫化钾反应。 Auranofin是一种抗关节炎药物化合物。 奥拉芬芬是一种口服活性的治疗剂,在人体中可用作抗关节炎。
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公开(公告)号:US4112113A
公开(公告)日:1978-09-05
申请号:US772034
申请日:1977-02-25
申请人: David T. Hill
发明人: David T. Hill
IPC分类号: C07F1/00 , A01N9/00 , C07D327/00 , C07D333/00
CPC分类号: C07F1/005 , Y10S514/825
摘要: The compounds are bis(sulfide)gold(1+) salts which have antiarthritic activity.
摘要翻译: 该化合物是具有抗关节活性的二(硫化物)金(1+)盐。
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