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61 条记录 (耗时 0.03 秒)

    Erythropoietin complementation or replacement
    31.
    发明申请
    Erythropoietin complementation or replacement 审中-公开
    红细胞生成素互补或替代

    公开(公告)号：US20080312138A1

    公开(公告)日：2008-12-18

    申请号：US12150946

    申请日：2008-05-01

    申请人： Claude Nicolau ,  Jean-Marie Lehn ,  Ruth Greferath

    发明人： Claude Nicolau ,  Jean-Marie Lehn ,  Ruth Greferath

    IPC分类号： A61K38/22 ,  A61K31/7042 ,  A61P7/06 ,  A61P7/00

    CPC分类号： A61K31/66 ,  A61K31/6615 ,  A61K35/15 ,  A61K38/1816 ,  A61K2300/00

    摘要： The present invention provides methods and compositions to replace up to 90% of erythropoietin use in the treatment of anemias and hypoxias. The method employs acid and salt forms of inositol-tripyrophosphate (ITPP) isomers to shift the P50 value of hemoglobin, thereby improving the rate and efficiency of oxygenation by blood even when red blood cell counts are low. Indications for the new method include anemias and hypoxia arising from infection, chemotherapy, premature birth, altitude change, compromised lung or heart function, aplastic anemia and anemia associated with a myelodysplastic syndrome, and other causes.

    摘要翻译： 本发明提供了用于替代高达90％的红细胞生成素用于治疗贫血和缺氧的方法和组合物。 该方法采用酸性和盐形式的肌醇三磷酸（ITPP）异构体来移动血红蛋白的P50值，从而即使红细胞计数低，也能提高血液氧合的速率和效率。 新方法的适应症包括感染，化疗，早产，高原变化，肺或心脏功能受损，再生障碍性贫血和与骨髓增生异常综合征相关的贫血引起的贫血和缺氧以及其他原因。

    Use of inositol-tripyrophosphate in treating tumors and diseases
    33.
    发明申请
    Use of inositol-tripyrophosphate in treating tumors and diseases 审中-公开
    使用肌醇三磷酸治疗肿瘤和疾病

    公开(公告)号：US20060258626A1

    公开(公告)日：2006-11-16

    申请号：US11396338

    申请日：2006-03-31

    申请人： Claude Nicolau ,  Ruth Greferath ,  Jean-Marie Lehn ,  Konstantina Fylaktakidou

    发明人： Claude Nicolau ,  Ruth Greferath ,  Jean-Marie Lehn ,  Konstantina Fylaktakidou

    IPC分类号： A61K31/66 ,  A61L9/04 ,  A61K8/46

    CPC分类号： A61K31/66 ,  C07F9/65746

    摘要： Inositol-tripyrophosphate is an allosteric effector of hemoglobin due to its ability to cross the plasma membrane of red blood cells and deliver oxygen to solid tumors, by lowering the oxygen affinity of the hemoglobin of red blood cells. The present invention is directed to the use of inositol-tripyrophosphate to reduce hemoglobin's affinity for oxygen in circulating red blood cells. The present invention is further directed to the use of inositol-tripyrophosphate to inhibit angiogenesis and enhance radiation sensitivity of hypoxic tumors. The present invention is further directed to the use of inositol-tripyrophosphate for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.

    摘要翻译： 肌醇三磷酸盐是血红蛋白的变构效应物，因为它能够通过降低红细胞血红蛋白的氧亲合力而穿过红细胞的质膜并将氧传递给实体瘤。 本发明涉及肌醇三磷酸降低血红蛋白在循环红细胞中对氧的亲和力的用途。 本发明还涉及肌醇三磷酸盐抑制血管发生和增强缺氧性肿瘤的放射敏感性的用途。 本发明还涉及肌醇三磷酸盐用于治疗各种类型的癌症，阿尔茨海默氏病，中风和骨质疏松症的用途。

    Compounds related to the amidinium family, pharmaceutical compositions containing same, and uses thereof
    34.
    发明授权
    Compounds related to the amidinium family, pharmaceutical compositions containing same, and uses thereof 失效
    与idin族有关的化合物，含有它们的药物组合物及其用途

    公开(公告)号：US06316422B1

    公开(公告)日：2001-11-13

    申请号：US09706619

    申请日：2000-11-06

    申请人： Jean-Marie Lehn ,  Pierre Lehn ,  Jean-Pierre Vigneron

    发明人： Jean-Marie Lehn ,  Pierre Lehn ,  Jean-Pierre Vigneron

    IPC分类号： A01N4304

    CPC分类号： C07J41/0055 ,  A61K9/1272

    摘要： Novel amidinium derivatives of formula (I), wherein R1 is a cholesterol derivative or an alkylamino-NR′R″ grouping, and each of R2 and R3 is independently a hydrogen atom or a grouping of formula (II), wherein each of R4 and R5 is independently a hydrogen atom or a grouping of formula (III), are disclosed. The corresponding pharmaceutical compositions, which are particularly useful in gene therapy for transferring therapeutic genes into cells, are also disclosed.

    摘要翻译： 式（I）的新型脒鎓衍生物，其中R1是胆固醇衍生物或烷基氨基-NR'R“基团，R2和R3各自独立地是氢原子或式（II）的基团，其中R4 和R 5独立地为氢原子或式（III）的基团。 还公开了相应的药物组合物，其特别可用于将治疗基因转移到细胞中的基因治疗。

    Imine based liquid crystals for the controlled release of bioactive materials
    40.
    发明授权
    Imine based liquid crystals for the controlled release of bioactive materials 有权
    用于控制释放生物活性物质的基于亚胺的液晶

    公开(公告)号：US08158135B2

    公开(公告)日：2012-04-17

    申请号：US12294398

    申请日：2007-03-19

    申请人： Jean-Marie Lehn ,  Nicolas Giuseppone ,  Andreas Herrmann

    发明人： Jean-Marie Lehn ,  Nicolas Giuseppone ,  Andreas Herrmann

    IPC分类号： A61K9/00

    CPC分类号： A61L9/12 ,  A01M1/2077 ,  A61L9/044 ,  A61L9/16

    摘要： The present invention relates to a delivery system based on a film of an imine forming liquid crystalline phase, mixed with at least with one biologically active substance, to which a constant or variable electric field can be applied. The delivery system can be used as a delivery system for biologically active substances such as flavors, fragrances, bactericides, fungicides, insecticides, insect attractants or repellents, agrochemicals or pharmaceuticals.

    摘要翻译： 本发明涉及一种基于形成液晶相的亚胺膜与至少一种生物活性物质混合的递送系统，可以施加恒定或可变电场。 输送系统可用作生物活性物质如香料，香料，杀菌剂，杀真菌剂，杀虫剂，昆虫引诱剂或驱虫剂，农用化学品或药物的递送系统。