公开(公告)号：US08328788B2

公开(公告)日：2012-12-11

申请号：US13105630

申请日：2011-05-11

Applicant: Julian L. Henley ,  Kuo Wei Chang ,  Joseph Potter ,  Dennis I. Goldberg ,  James Derouin

Inventor： Julian L. Henley ,  Kuo Wei Chang ,  Joseph Potter ,  Dennis I. Goldberg ,  James Derouin

IPC: A61N1/30

CPC classification number: A61N1/325 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/30

Abstract: A method for delivering a substance to an infected nail of an individual is described. The method includes the step of applying a device to at least one infected nail of an individual, where the device includes at least one active electrode and at least one counter electrode, where the at least one counter electrode is in contact with the individual, and where the device is connected to at least one power source. The method also includes the steps of disposing a medicament between the at least one active electrode and the at least one infected nail, applying a salt solution to the at least one infected nail, and providing an electrical current from the power source to the at least one active electrode to facilitate delivery of the medicament into the region of the at least one infected nail.

Abstract translation: 描述了将物质递送到个体的感染指甲的方法。 该方法包括将装置应用于个体的至少一个受感染的钉，其中该装置包括至少一个有效电极和至少一个对电极，其中至少一个对电极与个体接触，以及 其中设备连接到至少一个电源。 该方法还包括以下步骤：在至少一个活性电极与至少一个受感染的指甲之间设置药物，将盐溶液施加到至少一个受感染的指甲，并且将电流从电源提供给至少 一个有源电极，以促进药物输送到至少一个感染的指甲的区域中。

公开(公告)号：US07127285B2

公开(公告)日：2006-10-24

申请号：US10359559

申请日：2003-02-07

Applicant: Julian L. Henley ,  Kuo Wei Chang ,  Joseph Potter ,  Dennis I. Goldberg ,  James Derouin

Inventor： Julian L. Henley ,  Kuo Wei Chang ,  Joseph Potter ,  Dennis I. Goldberg ,  James Derouin

IPC: A61N1/30

CPC classification number: A61N1/044 ,  A61N1/30 ,  A61N1/325

Abstract: A system for delivering a substance into a body at a treatment site that includes an alternating current source and a plurality of electrodes. Circuitry is connected between the alternating current source and the electrodes for supplying current to the electrodes when the electrodes are in electrical contact with said body so that a uni-directional current flow for delivering the substance into the body is maintained at the treatment site and a bi-directional current flow is maintained throughout the body. At least one of the electrodes is divided into sub-electrodes to, for example, reduce hazards associated with current concentration. These and other systems and methods are adaptable for large treatment areas and/or use a convenient and low-cost arrangement of electronics.

Abstract translation: 一种用于在包括交流电源和多个电极的治疗部位将物质递送到体内的系统。 电路连接在交流电源和电极之间，用于当电极与所述主体电接触时向电极提供电流，从而将物质输送到体内的单向电流保持在治疗部位，并且 在整个身体中保持双向电流。 电极中的至少一个被分成子电极，以例如减少与电流集中相关的危险。 这些和其他系统和方法适用于大型治疗区域和/或使用方便且低成本的电子设备。

公开(公告)号：US06792306B2

公开(公告)日：2004-09-14

申请号：US10117346

申请日：2002-04-08

Applicant: Julian L. Henley ,  Kuo Wei Chang ,  Joseph Potter ,  Dennis I. Goldberg

Inventor： Julian L. Henley ,  Kuo Wei Chang ,  Joseph Potter ,  Dennis I. Goldberg

IPC: A61N130

CPC classification number: A61N1/325 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/30

Abstract: An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual includes a device shaped to conform with the shape of a portion of an individual's finger from a tip thereof to a location past the first finger joint. A self-contained power source is carried by the device and a first electrode is carried by the device adjacent a distal end portion thereof and the tip of the individual's finger. The first electrode is in electrical contact with the power source. A second electrode is carried by the device for contact with the individual's finger. The second electrode is in electrical contact with the power source. Upon application of the first electrode over a treatment site with the medicament disposed between the first electrode and the treatment site and completion of an electrical circuit through the individual's body and said electrode, the device applies current for electrokinetically driving the medicament into the treatment site.

Abstract translation: 个人使用的用于药物自身给药到个体治疗部位的电动输送系统包括成形为符合个体手指的一部分从其尖端到经过第一手指关节的位置的形状的装置。 该装置携带独立的电源，并且第一电极由邻近其远端部分和个体手指的尖端的装置承载。 第一电极与电源电接触。 第二电极由装置承载以与个体的手指接触。 第二电极与电源电接触。 当将第一电极施加在处理位置上时，药物设置在第一电极和处理部位之间，并通过个体的身体和所述电极完成电路，该装置施加用于电动驱动药物的电流到治疗部位。

公开(公告)号：US4469562A

公开(公告)日：1984-09-04

申请号：US454421

申请日：1982-12-29

Applicant: Kuo-Wei Chang

Inventor： Kuo-Wei Chang

IPC: G01N27/28 ,  G01N27/40 ,  G01N27/49 ,  G01N27/46

CPC classification number: G01N27/4045

Abstract: An electrolyte anion exchange sensor having a first diffusion membrane is spaced apart from an anion exchange membrane to form a cathodic cell. A second diffusion membrane is spaced apart from the anion exchange to form an anodic cell. CO.sub.2 flows through the first membrane and is ionized. The bicarbonate ions flow through the anion exchange membrane into the anodic compartment and reacts to form CO.sub.2. The current change in the electrolyte path corresponds to the amount of CO.sub.2.

Abstract translation: 具有第一扩散膜的电解质阴离子交换传感器与阴离子交换膜间隔开以形成阴极电池。 第二扩散膜与阴离子交换器间隔开以形成阳极电池。 CO 2流过第一膜并被电离。 碳酸氢根离子流过阴离子交换膜进入阳极室并反应形成二氧化碳。 电解质通路中的电流变化对应于二氧化碳的量。