公开(公告)号：US20090209611A1

公开(公告)日：2009-08-20

申请号：US12383721

申请日：2009-03-25

Applicant: Revital Lifshitz-Liron ,  Tamas Koltai ,  Judith Aronhime ,  Nurit Perlman ,  Sharon Avhar-Maydan

Inventor： Revital Lifshitz-Liron ,  Tamas Koltai ,  Judith Aronhime ,  Nurit Perlman ,  Sharon Avhar-Maydan

IPC: A61K31/404 ,  C07D209/12 ,  A61P3/06

CPC classification number: C07D209/12 ,  C07D209/24

Abstract: Provided are crystalline forms of fluvastatin sodium and processes for their preparation.

公开(公告)号：US20090105490A1

公开(公告)日：2009-04-23

申请号：US12218369

申请日：2008-07-14

Applicant: Nurit Perlman ,  Michal Rafilovich ,  Rinat Moshkovits-Kaptsan ,  Elena Ben Moha-Lerman ,  Revital Lifshitz-Liron

Inventor： Nurit Perlman ,  Michal Rafilovich ,  Rinat Moshkovits-Kaptsan ,  Elena Ben Moha-Lerman ,  Revital Lifshitz-Liron

IPC: C07D307/77

CPC classification number: C07D307/77

Abstract: An amorphous form of ramelteon is provided, as well as mixtures of amorphous and crystalline ramelteon. Also provided are methods of preparing amorphous ramelteon and mixtures of amorphous and crystalline ramelteon, pharmaceutical compositions comprising amorphous ramelteon and mixtures of amorphous and crystalline ramelteon, and methods of treatment of insomnia using the compositions of the invention.

Abstract translation: 提供了无定形形式的拉面，以及无定形和结晶拉米尔顿的混合物。 还提供了制备无定形拉米尔顿的方法以及无定形和结晶拉米尔顿的混合物，包含无定形拉米尔顿的药物组合物和无定形和结晶拉米尔顿的混合物的方法，以及使用本发明的组合物治疗失眠的方法。

公开(公告)号：US20090099365A1

公开(公告)日：2009-04-16

申请号：US12218401

申请日：2008-07-14

Applicant: Nurit Perlman ,  Gideon Pilarski

Inventor： Nurit Perlman ,  Gideon Pilarski

IPC: C07D453/04

CPC classification number: C07D453/02

Abstract: Processes for preparing solifenacin comprising distilling ethanol and organic solvent from a reaction mixture and recycling the organic solvent are described. Also described are processes for reducing solifenacin diastereomeric and enantiomeric impurities.

Abstract translation: 描述了制备索非那新的方法，其包括从反应混合物中蒸馏出乙醇和有机溶剂并回收有机溶剂。 还描述了降低索非那新非对映体和对映异构体杂质的方法。

公开(公告)号：US20090093627A1

公开(公告)日：2009-04-09

申请号：US12231438

申请日：2008-09-02

Applicant: Lorand Szabo ,  Laszlo Toth ,  Nurit Perlman

Inventor： Lorand Szabo ,  Laszlo Toth ,  Nurit Perlman

IPC: C07D205/08 ,  C12P17/10

CPC classification number: C12P17/10

Abstract: Processes of preparing an ezetimibe intermediate by microbial reduction and further converting the intermediate to ezetimibe are provided. Also provided is an ezetimibe intermediate with high diastereomeric excess.

Abstract translation: 提供了通过微生物还原制备依泽替米贝中间体并进一步将中间体转化为依泽替米贝的方法。 还提供了具有高非对映异构体过量的依泽替米贝中间体。