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    Crystalline forms of ibandronic acid and processes for the preparation thereof
    5.
    发明申请
    Crystalline forms of ibandronic acid and processes for the preparation thereof 审中-公开
    伊班膦酸的结晶形式及其制备方法

    公开(公告)号：US20090099390A1

    公开(公告)日：2009-04-16

    申请号：US12284811

    申请日：2008-09-24

    申请人： Claude Singer ,  Sharon W. Avhar-Maydan ,  Tamas Koltai ,  Amir Gold

    发明人： Claude Singer ,  Sharon W. Avhar-Maydan ,  Tamas Koltai ,  Amir Gold

    IPC分类号： C07F9/38

    CPC分类号： C07F9/386 ,  C07F9/3873

    摘要： A crystalline ibandronic acid characterized by data selected from the group consisting of at least one of a powder x-ray diffraction pattern having peaks at about 4.1, 12.3 and 13.4±0.2 degrees two-theta and at least two more peaks selected from the group consisting of: 8.2, 11.3, 16.2 and 16.9 and 20.8±0.2 degrees two-theta, and by a powder X-ray diffraction pattern depicted in FIG. 1 is provided. Also provided is a crystalline ibandronic acid characterized by data selected from the group consisting of at least one of a powder x-ray diffraction pattern having peaks at about peaks at about 5.2, 11.7, and 18.7±0.2 degrees two-theta and at least two more peaks selected from the group consisting of: 5.8, 10.1, 12.0, 17.1, and 20.0±0.2 degrees two-theta and a powder X-ray diffraction pattern as depicted in FIG. 2. Methods of preparing the crystalline forms are also provided.

    摘要翻译： 一种结晶伊班膦酸，其特征在于选自以下的数据：至少一种粉末X射线衍射图，其具有在约4.1,12.3和13.4±0.2度2-θ以及至少两个以上的峰，所述峰选自 ：8.2,11.3,16.2和16.9和20.8±0.2度2-θ，以及图1中所示的粉末X射线衍射图。 1。 还提供了结晶伊班膦酸，其特征在于选自以下的数据：粉末x射线衍射图中的至少一种，其峰值在约5.2,11.7和18.7±0.2度2θ和至少两个 选自由5.8，10.1，12.0,17.1和20.0±0.2度2-θ组成的组的更多峰和如图1所示的粉末X射线衍射图。 还提供了制备结晶形式的方法。

    DNT-fumarate and methods of preparation thereof
    10.
    发明申请
    DNT-fumarate and methods of preparation thereof 审中-公开
    DNT-富马酸盐及其制备方法

    公开(公告)号：US20070191471A1

    公开(公告)日：2007-08-16

    申请号：US11525622

    申请日：2006-09-21

    申请人： Santiago Ini ,  Anita Liberman ,  Mili Abramov ,  Tamas Koltai

    发明人： Santiago Ini ,  Anita Liberman ,  Mili Abramov ,  Tamas Koltai

    IPC分类号： A61K31/38

    CPC分类号： C07D333/16 ,  A61K31/38 ,  C07D333/20

    摘要： (S)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine fumarate (DNT-fumarate) and polymorphs of DNT-fumarate, compositions of DNT-fumarate and its polymorphs, processes for the preparation of DNT-fumarate and its polymorphs, and processes for the preparation of duloxetine hydrochloride from DNT-fumarate are provided.

    摘要翻译： （S）-N，N-二甲基-3-（1-萘氧基）-3-（2-噻吩基）丙胺富马酸盐（DNT-富马酸盐）和DNT-富马酸盐的多晶型物，DNT-富马酸盐的组成及其多晶型物， 提供了DNT-富马酸盐及其多晶型物的制备，以及从DNT-富马酸盐制备盐酸度洛西汀的方法。