公开(公告)号：US5985931A

公开(公告)日：1999-11-16

申请号：US11841

申请日：1998-06-02

Applicant: Shanta Modak ,  Lester Sampath

Inventor： Shanta Modak ,  Lester Sampath

IPC: A01N47/44 ,  A61K31/155

CPC classification number: A01N47/44

Abstract: The present invention relates to antimicrobial compositons comprising (i) less than or equal to two percent by weight chlorhexidine or chlorhexidine salt; (ii) less than or equal to 1 percent by weight of a quaternary ammonium compound, such as benzalkonium chloride; and (iii) less than or equal to two percent by weight of parachlorometaxylenol. The antimicrobial compositions of the invention may be utilized in antimicrobial deterents, soaps, creams rinses, and emulsions for use in the medical community as well as general public use.

Abstract translation: PCT No.PCT / US96 / 18104 Sec。 371日期1998年6月2日 102（e）1998年6月2日PCT PCT 1996年11月12日PCT公布。 出版物WO97 / 17849 日期1997年5月22日本发明涉及抗微生物组合物，其包含（i）小于或等于2重量％的氯己定或氯己定盐; （ii）小于或等于1重量％的季铵化合物，例如苯扎氯铵; 和（iii）小于或等于2％（重量）的对氯甲ax en酚。 本发明的抗微生物组合物可用于抗菌消毒剂，肥皂，乳膏漂洗剂和用于医学界的乳剂以及一般公众使用。

公开(公告)号：US5705532A

公开(公告)日：1998-01-06

申请号：US556256

申请日：1995-11-13

Applicant: Shanta Modak ,  Lester Sampath

Inventor： Shanta Modak ,  Lester Sampath

IPC: A01N47/44 ,  A01N31/08 ,  A01N33/12 ,  A01N37/52

CPC classification number: A01N47/44

Abstract: The present invention relates to antimicrobial compositions comprising (i) less than or equal to two percent by weight chlorhexidine or chlorhexidine salt; (ii) less than or equal to 0.1 percent by weight of a quaternary ammonium compound such as benzalkonium chloride; and (iii) less than or equal to two percent by weight of parachlorometaxylenol. The antimicrobial compositions of the invention may be utilized in antimicrobial detergents, soaps, creams, rinses, and emulsions for use in the medical community as well as general public use.

Abstract translation: 本发明涉及抗微生物组合物，其包含（i）小于或等于2重量％的氯己定或氯己定盐; （ii）小于或等于0.1重量％的季铵化合物如苯扎氯铵; 和（iii）小于或等于2％（重量）的对氯甲ax en酚。 本发明的抗微生物组合物可以用于医学界中使用的抗微生物洗涤剂，肥皂，乳膏，漂洗剂和乳剂，以及一般公众使用。

公开(公告)号：US5567495A

公开(公告)日：1996-10-22

申请号：US273329

申请日：1994-07-11

Applicant: Shanta Modak ,  Lester Sampath

Inventor： Shanta Modak ,  Lester Sampath

IPC: A61L29/16 ,  A61M25/00 ,  B29D22/00

CPC classification number: A61L29/16 ,  A61M25/0017 ,  A61L2300/104 ,  A61L2300/206 ,  A61L2300/404 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/1397

Abstract: The present invention provides for medical devices which are antiinfective as a result of antiinfective agents impregnated onto their surfaces and/or antiinfective activity incorporated into their access sites. It is based, at least in part, on the discovery that certain combinations of antimicrobial agents and solvents change the surface characteristics of polymeric medical devices, thereby facilitating the retention of antimicrobial agents. It is further based on the discovery that the incorporation of antiinfective polymeric inserts into the access site of a medical device provides substantially improved antiinfective activity.

Abstract translation: 本发明提供了由于浸渍在其表面上的抗感染剂和/或并入其进入部位的抗感染活性而具有抗感染性的医疗器械。 至少部分地基于以下发现：抗微生物剂和溶剂的某些组合改变聚合物医疗装置的表面特性，从而有助于抗微生物剂的保留。 进一步基于以下发现：将抗感染聚合物插入物并入医疗装置的进入部位提供了显着改善的抗感染活性。

公开(公告)号：US4563485A

公开(公告)日：1986-01-07

申请号：US605792

申请日：1984-04-30

Applicant: Charles L. Fox, Jr. ,  Shanta Modak ,  Keith Reemtsma

Inventor： Charles L. Fox, Jr. ,  Shanta Modak ,  Keith Reemtsma

IPC: A61K31/47 ,  A61K31/495 ,  A61K31/505 ,  A61L17/00 ,  A61L27/54 ,  A61L29/16 ,  A61K31/625

CPC classification number: A61K31/495 ,  A61K31/47 ,  A61K31/505 ,  A61L17/005 ,  A61L27/54 ,  A61L29/16 ,  A61L2300/104 ,  A61L2300/21 ,  A61L2300/224 ,  A61L2300/404

Abstract: Infection-resistant materials, and methods of preparing same, suitable for use within the interior of a human or animal body in such forms as vascular grafts prostheses, or other implanted devices. The material is rendered infection-resistant by incorporating therein antimicrobial agents, such as nalidixic acid derivatives or metal salts of nalidixic acid derivatives. In particular illustrative embodiments, silver norfloxacin and silver pefloxacin, are complexed with natural or synthetic polymeric materials such as silk, polyester (e.g., Dacron), polyurethane, polytetrafluoroethylene, or silicone-based material, to provide long-term prevention of infections which may otherwise result during or after surgery or implantation of a device.

Abstract translation: 感染抗性材料及其制备方法，适合在人体或动物体内部以血管移植假体或其它植入装置的形式使用。 通过掺入其中的抗微生物剂，例如萘啶酸衍生物或萘啶酸衍生物的金属盐，使材料变得具有抗感染性。 特别说明性的实施例中，诺氟沙星银和普洛沙星银与天然或合成聚合材料如丝，聚酯（例如，涤纶），聚氨酯，聚四氟乙烯或硅氧烷基材料络合，以提供长期预防感染， 否则会在手术或植入手术期间或之后产生。