公开(公告)号：US20090123928A1

公开(公告)日：2009-05-14

申请号：US12247464

申请日：2008-10-08

申请人： Laura D. Wood ,  Williams D. Parsons ,  Sian Jones ,  Jimmy Lin ,  Tobias Sjoblom ,  Thomas Barber ,  Giovanni Parmigiani ,  Victor Velculescu ,  Kenneth W. Kinzler ,  Bert Vogelstein

发明人： Laura D. Wood ,  Williams D. Parsons ,  Sian Jones ,  Jimmy Lin ,  Tobias Sjoblom ,  Thomas Barber ,  Giovanni Parmigiani ,  Victor Velculescu ,  Kenneth W. Kinzler ,  Bert Vogelstein

IPC分类号： C12Q1/68 ,  C12Q1/02

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/156

摘要： Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalogue the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene “mountains” and a much larger number of gene “hills” that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy.

摘要翻译： 人类癌症是由致癌基因和肿瘤抑制基因突变的积累引起的。 为了列出肿瘤发生过程中发生的遗传变化，我们从11个乳腺和11个结肠直肠肿瘤中分离出DNA，并在这些样品中确定了参考序列数据库中的基因序列。 根据对18,191个基因的20,857个转录本的外显子的分析，我们得出结论，乳腺癌和结肠直肠癌的基因组景观由少数常见的突变基因“山”组成，更多的基因“山”在低位突变 频率。 我们描述了统计和生物信息学工具，可以帮助识别在肿瘤发生中发挥作用的突变。 这些结果有助于了解人类癌症的性质和异质性以及使用个人基因组学进行肿瘤诊断和治疗。

公开(公告)号：USD580798S1

公开(公告)日：2008-11-18

申请号：US29287491

申请日：2007-08-15

申请人： Thomas Barber

设计人： Thomas Barber

CPC分类号： G01F19/00 ,  A47G19/12

公开(公告)号：US20050127917A1

公开(公告)日：2005-06-16

申请号：US10707424

申请日：2003-12-12

申请人： Thomas Barber

发明人： Thomas Barber

IPC分类号： G01V3/28 ,  G01V3/18

CPC分类号： G01V3/20

摘要： A well logging tool includes an induction array stack disposed on a mandrel; an electronic module stack disposed adjacent the induction array stack along a longitudinal axis of the well logging tool; and a shallow electrode array arranged on a housing disposed around the electronic module stack, wherein the induction array stack comprises a transmitter antenna, a first receiver antenna, and a second receiver antenna spaced apart from each other along the longitudinal axis of the well logging tool, the second receiver antenna being disposed between the transmitter antenna and the first receiver antenna.

摘要翻译： 井测工具包括设置在心轴上的感应阵列堆叠; 电子模块堆叠沿着测井工具的纵向轴线设置在感应阵列堆叠附近; 以及布置在设置在所述电子模块堆叠周围的壳体上的浅电极阵列，其中所述感应阵列堆叠包括发射器天线，第一接收器天线和沿着所述测井仪器的纵向轴线间隔开的第二接收器天线 第二接收天线设置在发射机天线和第一接收机天线之间。

公开(公告)号：US20050088181A1

公开(公告)日：2005-04-28

申请号：US10707813

申请日：2004-01-14

申请人： THOMAS BARBER ,  STEPHEN BONNER ,  DEAN HOMAN ,  GERALD MINERBO ,  RICHARD ROSTHAL ,  KUO-CHIANG CHEN

发明人： THOMAS BARBER ,  STEPHEN BONNER ,  DEAN HOMAN ,  GERALD MINERBO ,  RICHARD ROSTHAL ,  KUO-CHIANG CHEN

IPC分类号： G01V3/28 ,  G01V3/08

CPC分类号： G01V3/28

摘要： A logging tool includes a tool body; a simple transmitter comprising a single antenna disposed on the tool body; four simple receivers, each comprising a single antenna, disposed on the tool body and spaced apart from the simple transmitter to form four arrays; and an electronic module for controlling operation of the four arrays, wherein the simple transmitter is configured to generate a magnetic field having a transverse component, wherein each of the four simple receivers is sensitive to the magnetic field generated by the simple transmitter, and at least one of the four simple receivers is sensitive to the transverse component of the magnetic field generated by the simple transmitter, and wherein the four arrays are configured to provide measurements at at least three depths of investigation.

摘要翻译： 测井工具包括工具体; 简单的发射机，包括设置在所述工具主体上的单个天线; 四个简单接收器，每个包括单个天线，设置在工具主体上并与简单发射器间隔开以形成四个阵列; 以及用于控制四个阵列的操作的电子模块，其中简单发射器被配置为产生具有横向分量的磁场，其中四个简单接收机中的每一个对由简单发射机产生的磁场敏感，并且至少 四个简单接收器之一对由简单发射器产生的磁场的横向分量敏感，并且其中四个阵列被配置为在至少三个调查深度提供测量。