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29 条记录 (耗时 0.038 秒)

    Genomic Landscapes of Human Breast and Colorectal Cancers
    1.
    发明申请
    Genomic Landscapes of Human Breast and Colorectal Cancers 审中-公开
    人类乳腺癌和结肠直肠癌的基因组学风景

    公开(公告)号：US20090123928A1

    公开(公告)日：2009-05-14

    申请号：US12247464

    申请日：2008-10-08

    申请人： Laura D. Wood ,  Williams D. Parsons ,  Sian Jones ,  Jimmy Lin ,  Tobias Sjoblom ,  Thomas Barber ,  Giovanni Parmigiani ,  Victor Velculescu ,  Kenneth W. Kinzler ,  Bert Vogelstein

    发明人： Laura D. Wood ,  Williams D. Parsons ,  Sian Jones ,  Jimmy Lin ,  Tobias Sjoblom ,  Thomas Barber ,  Giovanni Parmigiani ,  Victor Velculescu ,  Kenneth W. Kinzler ,  Bert Vogelstein

    IPC分类号： C12Q1/68 ,  C12Q1/02

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/156

    摘要： Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalogue the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene “mountains” and a much larger number of gene “hills” that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy.

    摘要翻译： 人类癌症是由致癌基因和肿瘤抑制基因突变的积累引起的。 为了列出肿瘤发生过程中发生的遗传变化，我们从11个乳腺和11个结肠直肠肿瘤中分离出DNA，并在这些样品中确定了参考序列数据库中的基因序列。 根据对18,191个基因的20,857个转录本的外显子的分析，我们得出结论，乳腺癌和结肠直肠癌的基因组景观由少数常见的突变基因“山”组成，更多的基因“山”在低位突变 频率。 我们描述了统计和生物信息学工具，可以帮助识别在肿瘤发生中发挥作用的突变。 这些结果有助于了解人类癌症的性质和异质性以及使用个人基因组学进行肿瘤诊断和治疗。

    Fuel filler neck assembly and method of fabricating
    6.
    发明授权
    Fuel filler neck assembly and method of fabricating 失效
    燃油加注口颈组件及其制造方法

    公开(公告)号：US07258145B2

    公开(公告)日：2007-08-21

    申请号：US10858948

    申请日：2004-05-28

    申请人： Douglas D. McCracken ,  Thomas Barber ,  Jamie R. Pritchard

    发明人： Douglas D. McCracken ,  Thomas Barber ,  Jamie R. Pritchard

    IPC分类号： B65B1/04

    CPC分类号： B60K15/04 ,  Y10S220/33

    摘要： A fuel filler neck assembly having a uniform hemmed connection between an outer funnel portion and an inner funnel portion. The outer funnel portion is typically defined by an offset-expanded cylinder and sidewalls of varying thickness. The inner funnel portion includes sidewalls that have an internal thread, which is configured to mate with the threads of a gas cap. A hemmed connection is used to join one end of the outer funnel portion to one end of the inner funnel portion. The sidewalls at one end of the outer funnel portion are folded or bent inwardly and around the rim portion to define a curled portion. A tooling assembly for producing a uniform hemmed connection between one end of the outer funnel portion and one end of the inner funnel portion. A method of producing a uniform hemmed connection between portions of a fuel filler neck.

    摘要翻译： 一种燃料填充器颈部组件，其在外漏斗部分和内漏斗部分之间具有均匀的卷边连接。 外漏斗部分通常由偏移扩大的圆筒和不同厚度的侧壁限定。 内漏斗部分包括具有内螺纹的侧壁，其构造成与气帽的螺纹配合。 使用褶边连接将外漏斗部分的一端连接到内漏斗部分的一端。 外漏斗部分的一端的侧壁被折叠或向内弯曲并围绕边缘部分以限定卷曲部分。 一种用于在外漏斗部分的一端和内漏斗部分的一端之间产生均匀的卷边连接的加工组件。 一种在燃料填充器颈部的部分之间产生均匀的褶皱连接的方法。

    [APPARATUS AND METHODS FOR INDUCTION-SFL LOGGING]
    8.
    发明申请
    [APPARATUS AND METHODS FOR INDUCTION-SFL LOGGING] 失效
    [用于感应SFL记录的装置和方法]

    公开(公告)号：US20050127917A1

    公开(公告)日：2005-06-16

    申请号：US10707424

    申请日：2003-12-12

    申请人： Thomas Barber

    发明人： Thomas Barber

    IPC分类号： G01V3/28 ,  G01V3/18

    CPC分类号： G01V3/20

    摘要： A well logging tool includes an induction array stack disposed on a mandrel; an electronic module stack disposed adjacent the induction array stack along a longitudinal axis of the well logging tool; and a shallow electrode array arranged on a housing disposed around the electronic module stack, wherein the induction array stack comprises a transmitter antenna, a first receiver antenna, and a second receiver antenna spaced apart from each other along the longitudinal axis of the well logging tool, the second receiver antenna being disposed between the transmitter antenna and the first receiver antenna.

    摘要翻译： 井测工具包括设置在心轴上的感应阵列堆叠; 电子模块堆叠沿着测井工具的纵向轴线设置在感应阵列堆叠附近; 以及布置在设置在所述电子模块堆叠周围的壳体上的浅电极阵列，其中所述感应阵列堆叠包括发射器天线，第一接收器天线和沿着所述测井仪器的纵向轴线间隔开的第二接收器天线 第二接收天线设置在发射机天线和第一接收机天线之间。

    Cover for food holder
    9.
    发明授权
    Cover for food holder 有权
    食品保护盖

    公开(公告)号：US09061793B2

    公开(公告)日：2015-06-23

    申请号：US12955682

    申请日：2010-11-29

    申请人： Thomas Barber

    发明人： Thomas Barber

    IPC分类号： A47J39/00 ,  B65D25/28 ,  B65D6/00 ,  B65D5/46 ,  B65D51/16

    CPC分类号： B65D11/105 ,  A47J39/006 ,  B65D5/46064 ,  B65D5/46184 ,  B65D25/2858 ,  B65D51/1605

    摘要： A cover for a food holder includes a body having an inner surface and an outer surface, the body having at least one aperture provided therein, the at least one aperture providing communication between the inner surface and the outer surface; and a serving implement having a first portion extending through the aperture along one of the inner and outer surfaces, and a second portion extending along the other of the inner and outer surfaces.

    摘要翻译： 用于食品保持器的盖包括具有内表面和外表面的本体，所述主体具有设置在其中的至少一个孔，所述至少一个孔提供内表面和外表面之间的连通; 以及服务器具，其具有沿着所述内表面和外表面中的一个延伸穿过所述孔的第一部分，以及沿着所述内表面和外表面中的另一个延伸的第二部分。