公开(公告)号：US20060160850A1

公开(公告)日：2006-07-20

申请号：US11334204

申请日：2006-01-18

Applicant: Chongqing Sun ,  William Ewing ,  Yanting Huang ,  Annapurna Pendri ,  Samuel Gerritz ,  Bruce Ellsworth ,  Natesan Murugesan

Inventor： Chongqing Sun ,  William Ewing ,  Yanting Huang ,  Annapurna Pendri ,  Samuel Gerritz ,  Bruce Ellsworth ,  Natesan Murugesan

IPC: A61K31/47 ,  C07D215/38 ,  A61K31/4709

CPC classification number: C07D215/38 ,  C07D215/48 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D417/06

Abstract: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, n, and Z are described herein.

Abstract translation: 本申请描述了根据式I的化合物，包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法，其单独和与一种或多种另外的 治疗剂。 化合物具有通式I：包括所有前药，药学上可接受的盐和立体异构体，R 1，R 2，R 3，N， 和Z。

公开(公告)号：US20060154956A1

公开(公告)日：2006-07-13

申请号：US11330656

申请日：2006-01-12

Applicant: Chongqing Sun ,  William Ewing ,  Yanting Huang ,  Yeheng Zhu

Inventor： Chongqing Sun ,  William Ewing ,  Yanting Huang ,  Yeheng Zhu

IPC: C07D471/02 ,  A61K31/4745

CPC classification number: C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R3a, R4, A, B, b, n, W, X, Y and Z are described herein.

Abstract translation: 本申请描述了根据式I的化合物，包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法，其单独和与一种或多种另外的 治疗剂。 该化合物具有通式I：包括所有前药，药学上可接受的盐和立体异构体，R 1，R 2，R 3，R 3， 本文描述了SUP，3a，R 4，A，B，b，n，W，X​​，Y和Z。