公开(公告)号：US07378418B2

公开(公告)日：2008-05-27

申请号：US11016135

申请日：2004-12-17

Applicant: Guixue Yu ,  William R. Ewing ,  Amarendra B. Mikkilineni ,  Annapurna Pendri ,  Philip M. Sher ,  Samuel Gerritz ,  Bruce A. Ellsworth ,  Gang Wu ,  Yanting Huang ,  Chongqing Sun ,  Natesan Murugesan ,  Zhengxiang Gu ,  Ying Wang ,  Doree Sitkoff ,  Stephen R. Johnson ,  Ximao Wu

Inventor： Guixue Yu ,  William R. Ewing ,  Amarendra B. Mikkilineni ,  Annapurna Pendri ,  Philip M. Sher ,  Samuel Gerritz ,  Bruce A. Ellsworth ,  Gang Wu ,  Yanting Huang ,  Chongqing Sun ,  Natesan Murugesan ,  Zhengxiang Gu ,  Ying Wang ,  Doree Sitkoff ,  Stephen R. Johnson ,  Ximao Wu

IPC: C07D487/04 ,  A61K31/4162 ,  A61P3/04 ,  A61P43/00

CPC classification number: C07D487/04

Abstract: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R6, R7, m and n are described herein.

Abstract translation: 本申请描述了根据式I的化合物，包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法，其单独和与一种或多种另外的 治疗剂。 该化合物具有通式I：包括所有前药，药学上可接受的盐和立体异构体，R 1，R 2，R 3，R 3， 本文描述了SUP 6，R 7，m和n。

公开(公告)号：US07314882B2

公开(公告)日：2008-01-01

申请号：US11330540

申请日：2006-01-12

Applicant: Chongqing Sun ,  William R. Ewing ,  Yanting Huang

Inventor： Chongqing Sun ,  William R. Ewing ,  Yanting Huang

IPC: C07D471/02 ,  A01N43/42 ,  A61K31/44

CPC classification number: C07D471/04

Abstract: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R3a, R4, n, Y and Z are described herein.

Abstract translation: 本申请描述了根据式I的化合物，包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法，其单独和与一种或多种另外的 治疗剂。 化合物具有通式I：包括所有药学上可接受的盐和立体异构体，R 1，R 2，R 3，R 3， 3a，R 4，n，Y和Z在本文中描述。

公开(公告)号：US20060154955A1

公开(公告)日：2006-07-13

申请号：US11330540

申请日：2006-01-12

Applicant: Chongqing Sun ,  William Ewing ,  Yanting Huang

Inventor： Chongqing Sun ,  William Ewing ,  Yanting Huang

IPC: C07D471/02 ,  A61K31/4745

CPC classification number: C07D471/04

Abstract: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R3a, R4, n, Y and Z are described herein.

Abstract translation: 本申请描述了根据式I的化合物，包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法，其单独和与一种或多种另外的 治疗剂。 化合物具有通式I：包括所有药学上可接受的盐和立体异构体，R 1，R 2，R 3，R 3， 3a，R 4，n，Y和Z在本文中描述。

公开(公告)号：US08710049B2

公开(公告)日：2014-04-29

申请号：US13549717

申请日：2012-07-16

Applicant: William R. Ewing ,  Yeheng Zhu ,  Chongqing Sun ,  Yanting Huang ,  Maheswaran Sivasamban Karatholuvhu

Inventor： William R. Ewing ,  Yeheng Zhu ,  Chongqing Sun ,  Yanting Huang ,  Maheswaran Sivasamban Karatholuvhu

IPC: A61K31/55 ,  A61K31/4418 ,  C07D209/52 ,  A61K31/403 ,  C07D413/10 ,  A61K31/454 ,  C07D401/12 ,  C07D401/04 ,  A61K31/506 ,  C07D207/14 ,  A61K31/402 ,  A61K31/4545 ,  C07D223/12 ,  C07D417/12 ,  A61K45/06 ,  C07D211/56

CPC classification number: A61K31/55 ,  A61K31/402 ,  A61K31/403 ,  A61K31/4418 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K45/06 ,  C07D207/14 ,  C07D209/52 ,  C07D211/56 ,  C07D223/12 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/12 ,  C07D451/02 ,  C07D453/06 ,  C07D471/08

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are agonists, partial agonists and modulators of the NPY Y4 receptor and may be used for the treatment and prophylaxis of various diseases and conditions.

Abstract translation: 本发明提供式（I）化合物或其立体异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是NPY Y4受体的激动剂，部分激动剂和调节剂，可用于治疗和预防各种疾病和病症。

公开(公告)号：US20130184262A1

公开(公告)日：2013-07-18

申请号：US13549717

申请日：2012-07-16

Applicant: William R. Ewing ,  Yeheng Zhu ,  Chongqing Sun ,  Yanting Huang ,  Maheswaran Sivasamban Karatholuvhu

Inventor： William R. Ewing ,  Yeheng Zhu ,  Chongqing Sun ,  Yanting Huang ,  Maheswaran Sivasamban Karatholuvhu

IPC: A61K31/55 ,  A61K31/4418 ,  C07D209/52 ,  A61K31/403 ,  C07D413/10 ,  A61K31/454 ,  C07D401/12 ,  C07D401/04 ,  A61K31/506 ,  C07D207/14 ,  A61K31/402 ,  A61K31/4545 ,  C07D223/12 ,  C07D417/12 ,  A61K45/06 ,  C07D211/56

CPC classification number: A61K31/55 ,  A61K31/402 ,  A61K31/403 ,  A61K31/4418 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K45/06 ,  C07D207/14 ,  C07D209/52 ,  C07D211/56 ,  C07D223/12 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/12 ,  C07D451/02 ,  C07D453/06 ,  C07D471/08

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are agonists, partial agonists and modulators of the NPY Y4 receptor and may be used for the treatment and prophylaxis of various diseases and conditions.

Abstract translation: 本发明提供式（I）化合物或其立体异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是NPY Y4受体的激动剂，部分激动剂和调节剂，可用于治疗和预防各种疾病和病症。

公开(公告)号：US07709647B2

公开(公告)日：2010-05-04

申请号：US12104553

申请日：2008-04-17

Applicant: Chongqing Sun ,  William R. Ewing ,  Yanting Huang ,  Annapurna Pendri ,  Samuel Gerritz ,  Bruce A. Ellsworth ,  Natesan Murugesan

Inventor： Chongqing Sun ,  William R. Ewing ,  Yanting Huang ,  Annapurna Pendri ,  Samuel Gerritz ,  Bruce A. Ellsworth ,  Natesan Murugesan

IPC: C07D215/38 ,  A61K31/4709

CPC classification number: C07D215/38 ,  C07D215/48 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D417/06

Abstract: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, n, and Z are described herein.

Abstract translation: 本申请描述了根据式I的化合物，包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法，其单独和与一种或多种另外的 治疗剂。 化合物具有通式I：包括所有前药，药学上可接受的盐和立体异构体，本文描述了R1，R2，R3，n和Z。

公开(公告)号：US07632837B2

公开(公告)日：2009-12-15

申请号：US11455039

申请日：2006-06-16

Applicant: Chongqing Sun ,  Yanting Huang ,  Doree F. Sitkoff ,  Taekyu Lee ,  William Ewing

Inventor： Chongqing Sun ,  Yanting Huang ,  Doree F. Sitkoff ,  Taekyu Lee ,  William Ewing

IPC: C07D487/04 ,  A61K31/5025

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the following general formula: including all prodrugs, solvates, pharmaceutically acceptable salts and stereoisomers, wherein A, B, R1, R2, R3 and R8 are described herein.

Abstract translation: 本申请描述了根据式I的化合物，包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法，其单独和与一种或多种另外的 治疗剂。 该化合物具有以下通式：包括所有前药，溶剂化物，药学上可接受的盐和立体异构体，其中A，B，R 1，R 2，R 3和R 8在本文中描述。

公开(公告)号：US07572808B2

公开(公告)日：2009-08-11

申请号：US11454322

申请日：2006-06-16

Applicant: Chongqing Sun ,  Philip M. Sher ,  Gang Wu ,  William R. Ewing ,  Yanting Huang ,  Taekyu Lee ,  Natesan Murugesan ,  Richard B. Sulsky

Inventor： Chongqing Sun ,  Philip M. Sher ,  Gang Wu ,  William R. Ewing ,  Yanting Huang ,  Taekyu Lee ,  Natesan Murugesan ,  Richard B. Sulsky

IPC: A61K31/44 ,  C07D471/02

CPC classification number: C07D471/04

Abstract: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents, and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the following general formula: including all prodrugs, solvates, pharmaceutically acceptable salts and stereoisomers, wherein R1, R2, R3, R4 and R5 are described herein.

Abstract translation: 本申请描述了根据式I的化合物，包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物，以及使用式I化合物单独和与一种或多种 其他治疗剂。 该化合物具有以下通式：包括所有前药，溶剂化物，药学上可接受的盐和立体异构体，其中本文描述了R1，R2，R3，R4和R5。

公开(公告)号：US20080200459A1

公开(公告)日：2008-08-21

申请号：US12104553

申请日：2008-04-17

Applicant: Chongqing Sun ,  William R. Ewing ,  Yanting Huang ,  Annapurna Pendri ,  Samuel Gerritz ,  Bruce A. Ellsworth ,  Natesan Murugesan

Inventor： Chongqing Sun ,  William R. Ewing ,  Yanting Huang ,  Annapurna Pendri ,  Samuel Gerritz ,  Bruce A. Ellsworth ,  Natesan Murugesan

IPC: A61K31/5377 ,  C07D215/00 ,  A61K31/47 ,  A61P3/00 ,  C07D295/00

CPC classification number: C07D215/38 ,  C07D215/48 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D417/06

Abstract: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, n, and Z are described herein.

Abstract translation: 本申请描述了根据式I的化合物，包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法，其单独和与一种或多种另外的 治疗剂。 化合物具有通式I：包括所有前药，药学上可接受的盐和立体异构体，R 1，R 2，R 3，N， 和Z。

公开(公告)号：US20050143381A1

公开(公告)日：2005-06-30

申请号：US11016135

申请日：2004-12-17

Applicant: Guixue Yu ,  William Ewing ,  Amarendra Mikkilineni ,  Annapurna Pendri ,  Philip Sher ,  Samuel Gerritz ,  Bruce Ellsworth ,  Gang Wu ,  Yanting Huang ,  Chongqing Sun ,  Natesan Murugesan ,  Zhengxiang Gu ,  Ying Wang ,  Doree Sitkoff ,  Stephen Johnson ,  Ximao Wu

Inventor： Guixue Yu ,  William Ewing ,  Amarendra Mikkilineni ,  Annapurna Pendri ,  Philip Sher ,  Samuel Gerritz ,  Bruce Ellsworth ,  Gang Wu ,  Yanting Huang ,  Chongqing Sun ,  Natesan Murugesan ,  Zhengxiang Gu ,  Ying Wang ,  Doree Sitkoff ,  Stephen Johnson ,  Ximao Wu

IPC: A61K31/5025 ,  C07D487/04 ,  A61K31/503

CPC classification number: C07D487/04

Abstract: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R6, R7, m and n are described herein.

Abstract translation: 本申请描述了根据式I的化合物，包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法，其单独和与一种或多种另外的 治疗剂。 该化合物具有通式I：包括所有前药，药学上可接受的盐和立体异构体，R 1，R 2，R 3，R 3， 本文描述了SUP 6，R 7，m和n。