公开(公告)号：US07993864B2

公开(公告)日：2011-08-09

申请号：US10537309

申请日：2003-12-01

Applicant: Derek Thomas Brown ,  Lisa Butler ,  Karen Dorothy Cromie ,  Meryn Ruth Griffiths ,  Alastair David Griffiths Lawson ,  Daniel John Lightwood

Inventor： Derek Thomas Brown ,  Lisa Butler ,  Karen Dorothy Cromie ,  Meryn Ruth Griffiths ,  Alastair David Griffiths Lawson ,  Daniel John Lightwood

IPC: C12P21/08 ,  G01N33/53

CPC classification number: C07K16/243 ,  C07K16/245 ,  G01N33/56972 ,  G01N33/582 ,  G01N33/6854

Abstract: The present invention provides a homogeneous assay for identifying an antibody producing cell producing an antibody which binds to a selected antigen comprising: a) providing a population of antibody producing cells; b) incubating said population of antibody producing cells with a selected antigen and a labeled anti-antibody antibody, wherein said anti-antibody antibody is capable of distinguishing cells producing an antibody which binds to the selected antigen from those cells which do not; and c) identifying an antibody producing cell capable of producing an antibody which binds to the selected antigen.

Abstract translation: 本发明提供用于鉴定产生与所选抗原结合的抗体的产生抗体的细胞的均质测定法，包括：a）提供抗体产生细胞群; b）将所述抗体产生细胞群与所选择的抗原和标记的抗体抗体一起孵育，其中所述抗体抗体能够区分产生与所选抗原结合的抗体的细胞， 和c）鉴定能产生结合所选抗原的抗体的抗体产生细胞。

公开(公告)号：US20100254978A1

公开(公告)日：2010-10-07

申请号：US12706993

申请日：2010-02-17

Applicant: Alastair David Griffiths Lawson ,  Andrew Malcolm Nesbitt ,  Andrew George Popplewell ,  Stevan Graham Shaw ,  Diana Shpektor ,  Yi Zhang

Inventor： Alastair David Griffiths Lawson ,  Andrew Malcolm Nesbitt ,  Andrew George Popplewell ,  Stevan Graham Shaw ,  Diana Shpektor ,  Yi Zhang

IPC: A61K39/395 ,  C07K16/16 ,  C07K2/00 ,  C07H21/04 ,  C12N15/74 ,  C12N5/10 ,  C12P21/00 ,  A61P37/02

CPC classification number: C07K16/2878 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/70578 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

Abstract translation: 本发明涉及对人OX40的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。