公开(公告)号：US12116405B2

公开(公告)日：2024-10-15

申请号：US17807939

申请日：2022-06-21

申请人： XBiotech Inc.

发明人： John Simard

IPC分类号： C07K16/24 ,  A61K39/00 ,  A61K39/395 ,  A61P27/02 ,  A61P29/00

CPC分类号： C07K16/245 ,  A61K39/39533 ,  A61K2039/505 ,  A61P27/02 ,  A61P29/00

摘要： Administration of a monoclonal Ab (mAb) that specifically targets IL-1α is useful to treating articular and extra-articular symptoms of arthritis.

公开(公告)号：US11932688B2

公开(公告)日：2024-03-19

申请号：US16228060

申请日：2018-12-20

申请人： Janssen Biotech, Inc.

发明人： John Simard

IPC分类号： A61K39/395 ,  C07K16/24 ,  A61K39/00

CPC分类号： C07K16/245 ,  A61K2039/505 ,  C07K2317/76

摘要： Administration of a mAb that specifically binds IL-1α is useful for treating tumor-associated diseases in human subjects.

公开(公告)号：US20240083997A1

公开(公告)日：2024-03-14

申请号：US18175849

申请日：2023-02-28

申请人： Novartis AG

发明人： Hermann GRAM ,  Thomas JUNG ,  Philip LOWE ,  Trevor MUNDEL ,  Timothy WRIGHT

IPC分类号： C07K16/24 ,  A61K39/395

CPC分类号： C07K16/245 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/76

摘要： This invention relates to methods employing IL-1 beta-ligand/IL-1 receptor disrupting compounds, such as IL-1 beta antibodies or IL-1 receptor antibodies, in the treatment and/or prevention of auto-inflammatory syndromes in mammals, particularly humans.

公开(公告)号：US20240034781A1

公开(公告)日：2024-02-01

申请号：US18483270

申请日：2023-10-09

申请人： Janssen Biotech, Inc.

发明人： John SIMARD

IPC分类号： C07K16/24 ,  C12N5/071 ,  C12N5/09 ,  G01N33/68 ,  C07K14/545

CPC分类号： C07K16/245 ,  C12N5/069 ,  C12N5/0693 ,  G01N33/6869 ,  C07K14/545 ,  G01N33/6863 ,  C07K14/5412

摘要： Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1α and (ii) a constant region that is effective at both activating the complement system though C1q binding and binding to several different Fc receptors.

公开(公告)号：US20230220063A1

公开(公告)日：2023-07-13

申请号：US16624130

申请日：2018-06-22

申请人： NOVARTIS AG

发明人： Monica LIGUEROS-SAYLAN ,  Patrice MATCHABA ,  Tom THUREN ,  Paul RIDKER ,  Peter LIBBY ,  Penelope OTTEWELL ,  Yang Yi LAU ,  Margaret DUGAN

IPC分类号： C07K16/24 ,  A61K39/00 ,  A61P35/00 ,  A61K9/00 ,  G01N33/574

CPC分类号： C07K16/245 ,  A61K9/0019 ,  A61K39/00114 ,  A61P35/00 ,  G01N33/57423 ,  A61K31/282 ,  A61K2039/54 ,  A61K2039/82 ,  A61K2039/86 ,  A61K2039/505 ,  A61K2039/545 ,  A61K2039/828 ,  A61K2039/836 ,  A61K2039/868

摘要： Use of an IL-1β binding antibody or a functional fragment thereof, especially canakinumab or a functional fragment thereof, or gevokizumab or a functional fragment thereof, and biomarkers for the treatment and/or prevention of cancer with at least partial inflammatory basis.

公开(公告)号：US20190233502A1

公开(公告)日：2019-08-01

申请号：US15779472

申请日：2016-11-23

申请人： Martha A. ALEXANDER-MILLER ,  Wake Forest University Health Sciences

发明人： Martha A Alexander-Miller

IPC分类号： C07K14/81 ,  C07K14/315 ,  A61P37/06 ,  C07K16/24 ,  A61P31/04 ,  C07K19/00 ,  A61K47/64 ,  A61K47/68

CPC分类号： C07K14/8103 ,  A61K39/092 ,  A61K39/39 ,  A61K39/40 ,  A61K47/642 ,  A61K47/646 ,  A61K47/6815 ,  A61K2039/507 ,  A61P31/04 ,  A61P37/06 ,  C07K14/315 ,  C07K16/244 ,  C07K16/245 ,  C07K16/246 ,  C07K16/249 ,  C07K19/00 ,  C12N9/485 ,  C12Y304/11022

摘要： An isolated or recombinant aminopeptidase N (pepN) polypeptide having inflammatory cytokine production and cytolysis inhibiting activity is provided. A method of inhibiting inflammatory cytokine production and cytolysis in a subject in need thereof is also provided, comprising administering to the subject an inflammatory cytokine production and cytolysis inhibiting amount of the isolated or recombinant pneumococcal pepN polypeptide. A method of treating a disease, disorder, or condition characterized by or associated with undesirable inflammatory cytokine production and cytolysis in a subject in need thereof is also provided, comprising administering to the subject a therapeutically effective amount of an isolated or recombinant pepN polypeptide. A method of treating pneumococcal infection in a subject in need thereof is also provided comprising administering to the subject a therapeutically effective amount of an anti-pepN polypeptide inhibitory agent.

公开(公告)号：US10000565B2

公开(公告)日：2018-06-19

申请号：US14442536

申请日：2013-11-14

申请人： Craig Basson ,  Mark Fishman ,  Tom Thuren ,  Shi Yin Foo

发明人： Craig Basson ,  Mark Fishman ,  Tom Thuren ,  Shi Yin Foo

IPC分类号： C07K16/24 ,  A61K39/00

CPC分类号： C07K16/245 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to a method for treating or alleviating the symptoms of peripheral arterial disease (PAD) in a subject, comprising administering about 25 mg to about 300 mg of an IL-1β binding antibody or functional fragment thereof.

公开(公告)号：US09915665B2

公开(公告)日：2018-03-13

申请号：US14141498

申请日：2013-12-27

申请人： AbbVie, Inc.

发明人： Lorenzo Benatuil ,  Jennifer Perez ,  Chung-Ming Hsieh

IPC分类号： G01N33/68 ,  C40B20/04 ,  C40B30/04 ,  C07K16/46 ,  C12N15/10 ,  C07K16/00 ,  C07K16/18 ,  C07K16/22 ,  C07K16/24

CPC分类号： G01N33/6854 ,  C07K16/005 ,  C07K16/18 ,  C07K16/22 ,  C07K16/244 ,  C07K16/245 ,  C07K16/468 ,  C07K2317/64 ,  C07K2317/92 ,  C12N15/1037 ,  C40B20/04 ,  C40B30/04

摘要： System and methods are disclosed for identifying and isolating antibodies with specific affinity with an antigen of interest. Multiple DNA libraries encoding antibodies or their fragments are designed such that the encoded antibodies from different libraries are tagged differently. These libraries may be transformed into yeast cells. The variants of the antibodies are displayed on the surface of the yeast cells and flow cytometry may be used to sort the cells based on antigen affinity and the different tags on the antibodies. By allowing multiple libraries to be screened simultaneously, the disclosed methods help improve the efficiency of affinity.

公开(公告)号：US20180009877A1

公开(公告)日：2018-01-11

申请号：US15547523

申请日：2016-02-23

申请人： Academia Sinica

发明人： An-Suei YANG ,  Hong-Sen CHEN ,  Ing-Chien CHEN ,  Chao-Ping TUNG ,  Shin-Chen HOU ,  Chung-Ming YU ,  Chi-Kai YANG ,  Yi-Kai CHIU

IPC分类号： C07K16/00 ,  C12N15/10 ,  C07K16/22 ,  C07K16/32

CPC分类号： C07K16/005 ,  C07K16/1018 ,  C07K16/18 ,  C07K16/22 ,  C07K16/245 ,  C07K16/2803 ,  C07K16/2827 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/32 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C12N15/1037

摘要： Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.

公开(公告)号：US09828438B2

公开(公告)日：2017-11-28

申请号：US15058460

申请日：2016-07-06

申请人： UCB PHARMA S.A.

发明人： David Paul Humphreys ,  Emma Dave ,  Laura Griffin ,  Sam Philip Heywood

IPC分类号： C07K16/00 ,  C07K16/46 ,  C07K16/18 ,  C07K16/24

CPC分类号： C07K16/468 ,  C07K16/00 ,  C07K16/18 ,  C07K16/245 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/522 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/569 ,  C07K2317/64 ,  C07K2317/92

摘要： The present invention provides dual specificity antibody fusion proteins comprising an antibody Fab or Fab′ fragment with specificity for an antigen of interest, said fragment being fused to at least one single domain antibody which has specificity for a second antigen of interest.