公开(公告)号：US20160280702A1

公开(公告)日：2016-09-29

申请号：US14442488

申请日：2013-11-12

Applicant: ARRAY BIOPHARMA INC.

Inventor： Barbara J. Brandhuber ,  Yutong Jiang ,  Gabrielle R. Kolakowski ,  Shannon L. Winski

IPC: C07D417/14 ,  C07D417/12 ,  C07D413/14

CPC classification number: C07D417/14 ,  C07D413/14 ,  C07D417/12

Abstract: Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.

公开(公告)号：US20160280681A1

公开(公告)日：2016-09-29

申请号：US14442584

申请日：2013-11-12

Applicant: ARRAY BIOPHARMA INC.

Inventor： Shelley Allen ,  James F. Blake ,  Barbara J. Brandhuber ,  Yutong Jiang ,  Gabrielle R. Kolakowski ,  Rui Xu ,  Shannon L. Winski

IPC: C07D401/14 ,  C07D231/56 ,  C07D231/52 ,  C07D403/04 ,  C07D401/12 ,  C07D401/04 ,  C07D231/40

CPC classification number: C07D401/14 ,  C07D231/40 ,  C07D231/44 ,  C07D231/52 ,  C07D231/56 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04

Abstract: Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.

公开(公告)号：US09155726B2

公开(公告)日：2015-10-13

申请号：US13913091

申请日：2013-06-07

Applicant: ARRAY BIOPHARMA INC.

Inventor： Michael J. Humphries ,  Shannon L. Winski

IPC: A61K31/4545 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/519 ,  A61K31/664 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/7076 ,  A61K33/24 ,  A61K45/06 ,  A61K31/4375 ,  A61K31/437

CPC classification number: A61K31/437 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/519 ,  A61K31/664 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/7076 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

Abstract: Methods of treating cancer by administering a DNA damaging agent and a CHK1 Inhibitor on a dosing regimen are provided.

Abstract translation: 提供了通过在给药方案上施用DNA损伤剂和CHK1抑制剂来治疗癌症的方法。