公开(公告)号：US10435403B2

公开(公告)日：2019-10-08

申请号：US15735138

申请日：2016-06-06

申请人： Bayer Pharma Aktiengesellschaft

发明人： Henrik Teller ,  Alexander Straub ,  Markus Brechmann ,  Thomas Müller ,  Mark Meininghaus ,  Katrin Nowak-Reppel ,  Hanna Tinel ,  Klaus Münter ,  Daniela Fliegner ,  Thomas Mondritzki ,  Melissa Boultadakis Arapinis ,  Tobias Marquardt ,  Alexandros Vakalopoulos ,  Anne-Sophie Rebstock ,  Matthias Beat Wittwer

IPC分类号： C07D471/04 ,  A61P9/04 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/513 ,  A61K31/5377 ,  A61K45/06 ,  C07D519/00

摘要： The present application relates to positive allosteric modulators of the muscarinic M2 receptor, especially to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular disorders and/or renal disorders.

公开(公告)号：US10150773B2

公开(公告)日：2018-12-11

申请号：US15548310

申请日：2016-02-02

申请人： Bayer Pharma Aktiengesellschaft

发明人： Alexandros Vakalopoulos ,  Damian Brockschnieder ,  Frank Wunder ,  Johannes-Peter Stasch ,  Tobias Marquardt ,  Lisa Dietz ,  Min Jian Volkhart Li

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/695 ,  A61K45/06 ,  C07B59/00 ,  C07F7/08

摘要： The present application relates to novel substituted imidazo[1,2-a]pyrazine carboxamides of general formula (I) to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

公开(公告)号：US20150274719A1

公开(公告)日：2015-10-01

申请号：US14440509

申请日：2013-11-04

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Alexandros Vakalopoulos ,  Markus Follmann ,  Ingo Hartung ,  Philipp Buchgraber ,  Rolf Jautelat ,  Jorma Hassfeld ,  Niels Lindner ,  Alexey Gromov ,  Frank Wunder ,  Johannes-Peter Stasch ,  Gorden Redlich ,  Volkhart Min-Jian Li ,  Eva Maria Becker-Pelster ,  Andreas Knorr

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61K45/06 ,  A61K31/496 ,  A61K31/541 ,  A61K31/4985 ,  C07D519/00 ,  A61K31/5377

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K45/06 ,  C07D471/08 ,  C07D519/00

摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

摘要翻译： 本申请涉及新的取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。