公开(公告)号：US20160039760A1

公开(公告)日：2016-02-11

申请号：US14818389

申请日：2015-08-05

Applicant: Dow AgroSciences LLC

Inventor： Matthew L. Grandbois ,  David S. Laitar ,  James M. Renga ,  Gregory T. Whiteker

IPC: C07D213/803 ,  B01J31/18

CPC classification number: C07D213/803 ,  B01J31/1815 ,  B01J2531/847

Abstract: 4,5,6-Trichloropicolinic acid is prepared by selectively dechlorinating 3,4,5,6-tetrachloropicolinic acid with zinc and a catalyst prepared from a nickel compound and a bidentate ligand in a polar solvent.

Abstract translation: 通过用锌和在极性溶剂中由镍化合物和二齿配体制备的催化剂选择性脱氯3,4,5,6-四氯吡啶酸来制备4,5,6-三氯吡啶甲酸。

公开(公告)号：US20160009649A1

公开(公告)日：2016-01-14

申请号：US14794430

申请日：2015-07-08

Applicant: DOW AGROSCIENCES LLC

Inventor： James M. Renga ,  Yuanming Zhu ,  Gregory T. Whiteker ,  Nakyen Choy

IPC: C07D213/84

CPC classification number: C07D213/803 ,  C07D213/79 ,  C07D213/84 ,  C07D307/54

Abstract: 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement.

Abstract translation: 4,6-二溴-3-羟基吡啶腈可以从选自氰基胺化，胺盐形成和溴化重排的一系列化学步骤中由糠醛制备。

公开(公告)号：US20140206881A1

公开(公告)日：2014-07-24

申请号：US14222912

申请日：2014-03-24

Applicant: Dow AgroSciences LLC

Inventor： Yuanming Zhu ,  Gregory T. Whiteker ,  James M. Renga ,  Kim E. Arndt ,  Gary Roth ,  David E. Podhorez ,  Scott P. West ,  Yang Cheng

IPC: C07D213/803

CPC classification number: C07D213/81 ,  C07D213/78 ,  C07D213/79 ,  C07D213/803

Abstract: 4-Amino-5-fluoro-3-halo-6-(substituted)picolinates are conveniently prepared from 4,5,6-trichloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange, halogenation, nitrile hydrolysis, esterification, and transition metal assisted coupling.

Abstract translation: 通过一系列涉及氟交换，胺化，卤素交换，卤化，腈水解，酯化等步骤的方法，可以方便地从4,5,6-三氯吡啶腈制备4-氨基-5-氟-3-卤代-6-（取代的） 和过渡金属辅助耦合。

公开(公告)号：US20140031556A1

公开(公告)日：2014-01-30

申请号：US13949060

申请日：2013-07-23

Applicant: Dow AgroSciences LLC

Inventor： James M. Renga ,  Yang Cheng ,  Joseck M. Muhuhi ,  David E. Podhorez ,  Gary A. Roth ,  Scott P. West ,  Gregory T. Whiteker ,  Yuanming Zhu

IPC: C07D213/803

CPC classification number: C07D213/803

Abstract: Provided herein are processes for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates comprising a step of converting chloropicolinoyl chlorides to fluoropicolinoyl fluorides.

Abstract translation: 本文提供了制备4-氨基-5-氟-3-卤代-6-（取代的）吡啶甲酸盐的方法，其包括将氯吡酰甲酰氯转化为氟吡啶酰基氟化物的步骤。

公开(公告)号：US09951018B2

公开(公告)日：2018-04-24

申请号：US15443446

申请日：2017-02-27

Applicant: Dow AgroSciences LLC

Inventor： Patrick S. Hanley ,  Nakyen Choy ,  Thomas L. Siddall ,  Gregory T. Whiteker

IPC: C07D213/803 ,  C07D213/84

CPC classification number: C07D213/803 ,  C07D213/84

Abstract: 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 2-hydroxypicolinonitrile in a series of chemical steps selected from chlorination, chloro substitution, nitrile hydrolysis and chloro reduction.

公开(公告)号：US20180009755A1

公开(公告)日：2018-01-11

申请号：US15642653

申请日：2017-07-06

Applicant: Dow AgroSciences LLC

Inventor： Gregory T. Whiteker ,  Nakyen Choy ,  Peter Borromeo ,  Nicholas R. Babij ,  Gary Roth ,  Patrick S. Hanley ,  Matthias S. Ober ,  Tina Staton ,  Daniel I. Knueppel ,  Grant Von Wald ,  Nicole Hough

IPC: C07D213/81 ,  C07C227/18

CPC classification number: C07D213/81 ,  C07C227/18 ,  C07C229/08 ,  C07C271/22

Abstract: A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic acid or 4-methoxy-3-hydroxypicolinic acid with a key 2-aminopropanoate ester derived from a 1,1-bis(4-fluorophenyl)propane-1,2-diol.

公开(公告)号：US20170247330A1

公开(公告)日：2017-08-31

申请号：US15443446

申请日：2017-02-27

Applicant: Dow AgroSciences LLC

Inventor： Patrick S. Hanley ,  Nakyen Choy ,  Thomas L. Siddall ,  Gregory T. Whiteker

IPC: C07D213/803 ,  C07D213/84

CPC classification number: C07D213/803 ,  C07D213/84

Abstract: 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 2-hydroxypicolinonitrile in a series of chemical steps selected from chlorination, chloro substitution, nitrile hydrolysis and chloro reduction.

公开(公告)号：US09440923B2

公开(公告)日：2016-09-13

申请号：US14818389

申请日：2015-08-05

Applicant: Dow AgroSciences LLC

Inventor： Matthew L. Grandbois ,  David S. Laitar ,  James M. Renga ,  Gregory T. Whiteker

IPC: C07D213/79 ,  C07D213/803 ,  B01J31/18

CPC classification number: C07D213/803 ,  B01J31/1815 ,  B01J2531/847

Abstract: 4,5,6-Trichloropicolinic acid is prepared by selectively dechlorinating 3,4,5,6-tetrachloropicolinic acid with zinc and a catalyst prepared from a nickel compound and a bidentate ligand in a polar solvent.

Abstract translation: 通过选择性地将3,4,5,6-四氯吡啶酸与锌和由镍化合物和二齿配体在极性溶剂中制备的催化剂选择性脱氯来制备4,5,6-三氯吡啶甲酸。

公开(公告)号：US09376388B2

公开(公告)日：2016-06-28

申请号：US14667109

申请日：2015-03-24

Applicant: Dow AgroSciences LLC

Inventor： James M. Renga ,  Yang Cheng ,  Joseck M. Muhuhi ,  David E. Podhorez ,  Gary A. Roth ,  Scott P. West ,  Gregory T. Whiteker ,  Yuanming Zhu

IPC: C07D213/78 ,  C07D213/803 ,  C07D213/55 ,  C07D213/807

CPC classification number: C07D213/55 ,  C07D213/78 ,  C07D213/803 ,  C07D213/807

Abstract: Provided herein are fluoropicolinoyl fluorides and processes for their preparation. In some embodiments, provided herein is a process for the preparation of 5-fluoro-6-aryl-picolinoyl fluorides from chloropicolinoyl chlorides.

公开(公告)号：US20150274669A1

公开(公告)日：2015-10-01

申请号：US14734347

申请日：2015-06-09

Applicant: Dow AgroSciences LLC

Inventor： Kim E. Arndt ,  James M. Renga ,  Yuanming Zhu ,  Gregory T. Whiteker ,  Christian T. Lowe

IPC: C07D213/84 ,  C07D213/79 ,  C07D213/81

CPC classification number: C07D213/84 ,  C07D213/79 ,  C07D213/803 ,  C07D213/81

Abstract: 4-Amino-3-chloro-5-fluoro-6-(substituted)picolinates are conveniently prepared from 3,4,5,6-tetrachloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange and hydrolysis, esterification and transition metal assisted coupling.

Abstract translation: 通过一系列涉及氟交换，胺化，卤素交换和水解，酯化和转化的步骤，方便地从3,4,5,6-四氯吡啶腈制备4-氨基-3-氯-5-氟-6-（取代的）吡啶甲酸盐 金属辅助联轴器。