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![NOVEL PHENYLETHYNYL DERIVATIVES OF 8-AZA-BICYCLO[3.2.1]OCTANE AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS](/abs-image/US/2011/01/20/US20110015235A1/abs.jpg.150x150.jpg)
31.发明申请NOVEL PHENYLETHYNYL DERIVATIVES OF 8-AZA-BICYCLO[3.2.1]OCTANE AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开8-AZA-BICYCLO [3.2.1] OCTAN的新型苯乙烯衍生物及其作为单胺神经递质抑制剂的用途公开(公告)号：US20110015235A1
公开(公告)日：2011-01-20
申请号：US12866044
申请日：2009-02-04
IPC分类号： A61K31/4439 , C07D401/12 , C07D209/52 , A61K31/403 , A61P25/24 , A61P25/00 , A61P25/28 , A61P25/16 , A61P25/30 , A61P25/34 , A61P25/36 , A61P25/32 , A61P29/00 , A61P19/02 , A61P15/10 , A61P13/00 , A61P15/12 , A61P21/00 , A61P25/22 , A61P3/04
CPC分类号： C07D451/06
摘要： This invention relates to novel phenylethynyl derivatives of 8-aza-bicyclo[3.2.1]octane useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的8-氮杂 - 双环[3.2.1]辛烷的新型苯乙炔衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![Novel Azabicyclo[3.2.1]Oct-2-Ene Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors](/abs-image/US/2010/11/11/US20100286193A1/abs.jpg.150x150.jpg)
32.发明申请Novel Azabicyclo[3.2.1]Oct-2-Ene Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors 审中-公开新型氮杂双环[3.2.1] Oct-2-Ene衍生物及其作为单胺神经递质重吸收抑制剂的用途公开(公告)号：US20100286193A1
公开(公告)日：2010-11-11
申请号：US11990015
申请日：2006-08-30
IPC分类号： A61K31/46 , C07D451/04 , C07D451/02 , A61P25/00 , A61P25/24 , A61P15/10 , A61P25/16 , A61P25/28 , A61P29/00
CPC分类号： C07D451/02
摘要： This invention relates to novel azabicyclo[3.2.1]oct-2-ene derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型氮杂双环[3.2.1]辛-2-烯衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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33.发明申请NOVEL PHENOXAZIN-3-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开新型苯氧基-3-酮衍生物及其作为单胺神经递质抑制剂的用途公开(公告)号：US20100286134A1
公开(公告)日：2010-11-11
申请号：US12677053
申请日：2008-09-08
IPC分类号： A61K31/538 , C07D451/12 , A61P25/00 , A61P25/24 , A61P25/28 , A61P15/00 , A61P29/00 , A61P25/30
CPC分类号： C07D413/12
摘要： This invention relates to novel phenoxazin-3-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新的吩恶嗪-3-酮衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE-RECEPTOR LIGANDS](/abs-image/US/2010/11/11/US20100286128A1/abs.jpg.150x150.jpg)
34.发明申请1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE-RECEPTOR LIGANDS 审中-公开1,4-DIAZA-BICYCLO [3.2.2] NONYL PYRIMIDINYL衍生物作为NICOTINIC乙酰胆碱受体配体有用公开(公告)号：US20100286128A1
公开(公告)日：2010-11-11
申请号：US12733184
申请日：2008-08-14
申请人： Dan Peters , Daniel B. Timmermann , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Jeppe Kejser Christensen , John Paul Redrobe , Tino Dyhring
发明人： Dan Peters , Daniel B. Timmermann , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Jeppe Kejser Christensen , John Paul Redrobe , Tino Dyhring
IPC分类号： A61K31/551 , C07D487/08 , A61P25/00 , A61P15/04 , A61P15/10 , A61P9/12 , A61P17/00 , A61P29/00
CPC分类号： C07D471/08
摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基嘧啶基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。
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![3,9-Diazabicyclo [3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2010/03/30/US07687517B2/abs.jpg.150x150.jpg)
35.发明授权3,9-Diazabicyclo [3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效3,9-二氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07687517B2
公开(公告)日：2010-03-30
申请号：US12159074
申请日：2007-02-09
IPC分类号： A61K31/47
CPC分类号： C07D519/00 , C07D471/08
摘要： Novel 3,9-diazabicyclo[3.3.1]nonane derivatives of formula (I) useful as monoamine neurotransmitter re-uptake inhibitors are provided: These compounds can also be used in methods for therapy and be included in pharmaceutical compositions comprising the compounds.
摘要翻译： 提供了可用作单胺神经递质再摄取抑制剂的式（I）的新型3,9-二氮杂双环[3.3.1]壬烷衍生物：这些化合物也可用于治疗方法，并且可以包含在包含该化合物的药物组合物中。
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36.发明申请CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 有权CHROMEN-2-ONE衍生物及其作为单胺神经递质抑制剂的用途公开(公告)号：US20120088789A1
公开(公告)日：2012-04-12
申请号：US13319955
申请日：2010-05-06
IPC分类号： A61K31/439 , A61P29/02 , A61P25/24 , C07D451/12 , A61P25/00
CPC分类号： C07D451/06 , A61K31/46
摘要： The present applications discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)-chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors. In other aspects the applications discloses the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本申请公开了新颖的8-氮杂 - 双环[3.2.1]辛-3-基氧基） - 苯并二氢吡喃-2-酮衍生物及其作为单胺神经递质再摄取抑制剂的用途。 在其它方面，申请公开了这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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公开(公告)号：US20120004257A1
公开(公告)日：2012-01-05
申请号：US13173178
申请日：2011-06-30
IPC分类号： A61K31/46 , A61P25/04 , A61P25/24 , C07D451/06 , A61P25/00
CPC分类号： C07D451/06
摘要： The present applications discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors. In other aspects the applications discloses the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本申请公开了新颖的8-氮杂 - 双环[3.2.1]辛-3-基氧基）色烯-2-酮衍生物及其作为单胺神经递质再摄取抑制剂的用途。 在其它方面，申请公开了这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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38.发明申请N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开N-ARYL-N-PIPERIDIN-4-YL-丙酰胺衍生物及其作为单胺神经递质抑制剂的用途公开(公告)号：US20110009449A1
公开(公告)日：2011-01-13
申请号：US12809284
申请日：2008-12-18
IPC分类号： A61K31/4468 , C07D211/58 , A61P25/24 , A61P25/00 , A61P25/28 , A61P25/22 , A61P3/04 , A61P25/16 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P29/00 , A61P25/04 , A61P19/02 , A61P13/00 , A61P15/10 , A61P15/12 , A61P15/00 , A61P43/00
CPC分类号： A61K31/4468 , C07D211/58
摘要： This invention relates to N-aryl-N-piperidin-4-yl-propionamide derivatives for use as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of pain, and to pharmaceutical compositions comprising the compounds, and to novel compounds.
摘要翻译： 本发明涉及用作单胺神经递质再摄取抑制剂的N-芳基-N-哌啶-4-基 - 丙酰胺衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途，例如用于治疗疼痛，以及包含该化合物的药物组合物以及新化合物。
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39.发明授权Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 有权色烯-2-酮衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US08697721B2
公开(公告)日：2014-04-15
申请号：US13319955
申请日：2010-05-06
IPC分类号： A01N43/42 , A61K31/44 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D421/00
CPC分类号： C07D451/06 , A61K31/46
摘要： The present applications discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)-chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors. In other aspects the applications discloses the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本申请公开了新颖的8-氮杂 - 双环[3.2.1]辛-3-基氧基） - 苯并二氢吡喃-2-酮衍生物及其作为单胺神经递质再摄取抑制剂的用途。 在其它方面，申请公开了这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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40.发明申请N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS 审中-公开N-ARYL-N-PIPERIDIN-4-YL-丙酰胺衍生物及其作为阿片受体配体的用途公开(公告)号：US20110046180A1
公开(公告)日：2011-02-24
申请号：US12809156
申请日：2008-12-18
IPC分类号： A61K31/445 , C07D211/56 , A61P17/00 , A61P25/36 , A61P25/00 , A61P25/04 , A61P25/32
CPC分类号： C07D211/58
摘要： This invention relates to novel N-aryl-N-piperidin-4-yl-propionamide derivatives useful as opioid receptor ligands.In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of pain, and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作阿片受体配体的新型N-芳基-N-哌啶-4-基 - 丙酰胺衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途，例如用于治疗疼痛，以及包含本发明化合物的药物组合物。
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