公开(公告)号：US08912210B2

公开(公告)日：2014-12-16

申请号：US13293177

申请日：2011-11-10

申请人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Anthony Ginnetti ,  Helen J. Mitchell ,  Daniel V. Paone ,  Donnette D. Staas ,  Cheng Wang ,  C. Blair Zartman

发明人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Anthony Ginnetti ,  Helen J. Mitchell ,  Daniel V. Paone ,  Donnette D. Staas ,  Cheng Wang ,  C. Blair Zartman

IPC分类号： A01N43/42 ,  A61K31/44 ,  C07D221/02

CPC分类号： A61K31/4545 ,  A61K31/435 ,  A61K31/438 ,  C07D471/10 ,  C07D471/20

摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

公开(公告)号：US20130231358A1

公开(公告)日：2013-09-05

申请号：US13884632

申请日：2011-11-10

申请人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Anthony Ginnetti ,  Helen J. Mitchell ,  Daniel V. Paone ,  Donnette D. Staas ,  Cheng Wang ,  Blair C. Zartman ,  Heather E. Stevenson

发明人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Anthony Ginnetti ,  Helen J. Mitchell ,  Daniel V. Paone ,  Donnette D. Staas ,  Cheng Wang ,  Blair C. Zartman ,  Heather E. Stevenson

IPC分类号： C07D471/04 ,  C07D487/04

CPC分类号： C07D471/04 ,  A61K31/506 ,  C07D487/04

摘要： The present invention is directed to piperidinone carboxamide indane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺二氢化茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20120122899A1

公开(公告)日：2012-05-17

申请号：US13293166

申请日：2011-11-10

申请人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Anthony Ginnetti ,  Helen J. Mitchell ,  Daniel V. Paone ,  Donnette D. Staas ,  Heather E. Stevenson ,  Cheng Wang ,  C. Blair Zartman

发明人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Anthony Ginnetti ,  Helen J. Mitchell ,  Daniel V. Paone ,  Donnette D. Staas ,  Heather E. Stevenson ,  Cheng Wang ,  C. Blair Zartman

IPC分类号： A61K31/439 ,  A61K31/527 ,  A61P25/06 ,  C07D471/20

CPC分类号： A61K31/4545 ,  A61K31/435 ,  A61K31/438 ,  C07D471/10 ,  C07D471/20

摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺氮杂茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US07732438B2

公开(公告)日：2010-06-08

申请号：US11665520

申请日：2005-10-12

申请人： Daniel V. Paone ,  Anthony W. Shaw ,  Craig M. Potteiger

发明人： Daniel V. Paone ,  Anthony W. Shaw ,  Craig M. Potteiger

IPC分类号： C07D401/00 ,  C07D487/00 ,  A61K31/55 ,  A61P25/00

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D519/00

摘要： Compounds of Formula (I) and Formula (II) (where variables R1, R2, R4, A, B, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 式（I）和式（II）化合物（其中变量R1，R2，R4，A，B，W，X，Y和Z如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20090192139A1

公开(公告)日：2009-07-30

申请号：US12417911

申请日：2009-04-03

申请人： Daniel V. Paone ,  Anthony W. Shaw

发明人： Daniel V. Paone ,  Anthony W. Shaw

IPC分类号： C07D401/14 ,  A61K31/55 ,  A61K31/553 ,  C07D413/14 ,  A61K31/4545 ,  A61K31/551

CPC分类号： C07D487/04 ,  C07D471/04

摘要： The present invention is directed to compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及式I化合物和式II：（其中变量R1，R2，R3，R4，A，B，G，J，Q，T，U，V，W，X和Y如上所定义 可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20120122900A1

公开(公告)日：2012-05-17

申请号：US13293177

申请日：2011-11-10

申请人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Anthony Ginnetti ,  Helen J. Mitchell ,  Daniel V. Paone ,  Donnette D. Staas ,  Cheng Wang ,  C. Blair Zartman

发明人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Anthony Ginnetti ,  Helen J. Mitchell ,  Daniel V. Paone ,  Donnette D. Staas ,  Cheng Wang ,  C. Blair Zartman

IPC分类号： A61K31/437 ,  A61K31/527 ,  A61P25/06 ,  C07D471/20

CPC分类号： A61K31/4545 ,  A61K31/435 ,  A61K31/438 ,  C07D471/10 ,  C07D471/20

摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

公开(公告)号：US10287293B2

公开(公告)日：2019-05-14

申请号：US15736202

申请日：2016-06-27

申请人： Merck Sharp & Dohme Corp. ,  Shawn J. Stachel ,  Christopher J. Sinz ,  Yili Chen ,  Jonathan E. Wilson ,  Michael P. Dwyer ,  Daniel V. Paone ,  Shimin Xu

发明人： Shawn J. Stachel ,  Michael P. Dwyer ,  Christopher J. Sinz ,  Jonathan E. Wilson ,  Daniel V. Paone ,  Yili Chen ,  Shimin Xu

IPC分类号： C07D487/04 ,  A61P25/28 ,  A61P25/22 ,  A61P25/18 ,  A61P25/16 ,  A61P25/06

摘要： The present invention is directed to dihydropyrazolopyrimidinone compounds of formulas (I) and (II) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.